SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 LYS A 174
LYS A 102
VAL A 176
 None
 0.79A 3brfA-1wdnA:
undetectable		 3brfA-1wdnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 SER A 193
ASP A  80
ASP A  63
 None
 0.76A 3iv6A-1wdnA:
undetectable		 3iv6A-1wdnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 SER A 193
ASP A  80
ASP A  63
 None
 0.75A 3iv6C-1wdnA:
undetectable		 3iv6C-1wdnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 202
ILE A  35
ASP A  83
LEU A 204
ARG A 208
 None
 1.15A 3iv6D-1wdnA:
undetectable		 3iv6D-1wdnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 GLY A  89
GLY A 119
PHE A  27
PHE A 221
 None
GLN  A 227 (-3.9A)
None
None
 0.85A 3ko0M-1wdnA:
undetectable
3ko0P-1wdnA:
undetectable		 3ko0M-1wdnA:
20.09
3ko0P-1wdnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLU A 145
ALA A 151
ALA A 124
ASP A 132
GLN A 135
 None
 1.09A 3nmuB-1wdnA:
undetectable
3nmuJ-1wdnA:
undetectable		 3nmuB-1wdnA:
20.05
3nmuJ-1wdnA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLU A 145
ALA A 151
ALA A 124
ASP A 132
GLN A 135
 None
 1.15A 3nvkF-1wdnA:
undetectable
3nvkJ-1wdnA:
undetectable		 3nvkF-1wdnA:
19.67
3nvkJ-1wdnA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 LYS A 125
SER A 116
GLN A 135
 None
 1.34A 3si7A-1wdnA:
undetectable		 3si7A-1wdnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 184
THR A 118
HIS A 156
LEU A  90
 None
GLN  A 227 (-4.2A)
GLN  A 227 (-4.0A)
None
 1.36A 4lvcC-1wdnA:
undetectable		 4lvcC-1wdnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 204
LEU A 196
LEU A  41
LEU A  39
LEU A  31
 None
 1.07A 4odoA-1wdnA:
undetectable		 4odoA-1wdnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 204
LEU A 196
LEU A  41
LEU A  39
LEU A  31
 None
 1.04A 4odoB-1wdnA:
undetectable		 4odoB-1wdnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
TYR A  86
ILE A 216
GLY A  26
HIS A 156
 GLN  A 227 (-3.9A)
None
None
None
GLN  A 227 (-4.0A)
 1.18A 4zdyA-1wdnA:
undetectable		 4zdyA-1wdnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 ILE A  69
PHE A  81
ARG A  75
ILE A  54
 None
None
GLN  A 227 (-3.0A)
None
 1.30A 4zzcA-1wdnA:
undetectable
4zzcB-1wdnA:
undetectable		 4zzcA-1wdnA:
21.78
4zzcB-1wdnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 ILE A  69
PHE A  81
ARG A  75
ILE A  54
 None
None
GLN  A 227 (-3.0A)
None
 1.32A 4zzcB-1wdnA:
undetectable
4zzcC-1wdnA:
undetectable		 4zzcB-1wdnA:
21.78
4zzcC-1wdnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
TYR A  86
ILE A 216
GLY A  26
HIS A 156
 GLN  A 227 (-3.9A)
None
None
None
GLN  A 227 (-4.0A)
 1.18A 5eslA-1wdnA:
undetectable		 5eslA-1wdnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 184
THR A 118
HIS A 156
LEU A  90
 None
GLN  A 227 (-4.2A)
GLN  A 227 (-4.0A)
None
 1.39A 6gbnA-1wdnA:
undetectable		 6gbnA-1wdnA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1wdn GLUTAMINE BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 GLN A 184
THR A 118
HIS A 156
LEU A  90
 None
GLN  A 227 (-4.2A)
GLN  A 227 (-4.0A)
None
 1.40A 6gbnD-1wdnA:
undetectable		 6gbnD-1wdnA:
22.63