SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 PHE B 236
PRO B 238
PHE B 239
PRO B 219
GLN B 210
 None
 1.39A 1fm4A-1wdwB:
0.0		 1fm4A-1wdwB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 0.94A 1hsgB-1wdwB:
undetectable		 1hsgB-1wdwB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 11 LEU B 182
ALA B  93
LEU B 121
ALA B 117
THR B 114
 None
 1.04A 1ictA-1wdwB:
undetectable
1ictC-1wdwB:
undetectable		 1ictA-1wdwB:
15.97
1ictC-1wdwB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		4 / 8 VAL A 163
TYR A  10
GLY A 197
GLU A  36
 None
 0.99A 1jlfA-1wdwA:
undetectable
1jlfB-1wdwA:
undetectable		 1jlfA-1wdwA:
19.66
1jlfB-1wdwA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 4 ARG B 205
LEU B  43
ASN B  40
VAL B 202
 None
 1.24A 1lqtA-1wdwB:
1.1		 1lqtA-1wdwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 4 ARG B 205
LEU B  43
ASN B  40
VAL B 202
 None
 1.26A 1lqtB-1wdwB:
1.2		 1lqtB-1wdwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 4 ARG B 205
LEU B  43
ASN B  40
VAL B 202
 None
 1.25A 1lquA-1wdwB:
2.2		 1lquA-1wdwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 4 ARG B 205
LEU B  43
ASN B  40
VAL B 202
 None
 1.26A 1lquB-1wdwB:
1.9		 1lquB-1wdwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		4 / 7 PHE A 138
ALA A 122
ILE A 112
ILE A  92
 None
 0.83A 1oniD-1wdwA:
undetectable
1oniF-1wdwA:
undetectable		 1oniD-1wdwA:
22.08
1oniF-1wdwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 11 VAL B 223
ASN B 369
GLU B  73
LEU B  53
ILE B 367
 None
 1.42A 1t6zA-1wdwB:
2.4		 1t6zA-1wdwB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 8 ASN B  85
HIS B  81
SER B 230
VAL B 186
 None
PLP  B 400 (-3.9A)
PLP  B 400 (-2.7A)
None
 1.36A 1u1jA-1wdwB:
undetectable		 1u1jA-1wdwB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		3 / 3 ALA A  27
THR A 235
PHE A  75
 None
 0.71A 2c6nB-1wdwA:
undetectable		 2c6nB-1wdwA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		4 / 7 THR A 156
ALA A 214
ASN A 215
PHE A   2
 None
 1.07A 2hzqA-1wdwA:
undetectable		 2hzqA-1wdwA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		3 / 3 ALA B 296
GLY B 227
SER B 371
 None
PLP  B 400 (-3.5A)
PLP  B 400 (-2.6A)
 0.51A 2ivuA-1wdwB:
undetectable		 2ivuA-1wdwB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 1.07A 2qhcB-1wdwB:
undetectable		 2qhcB-1wdwB:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 11 PHE B 199
ARG B 205
TYR B  26
ILE B 195
PHE B  35
 None
 1.38A 2vn1A-1wdwB:
undetectable		 2vn1A-1wdwB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 7 SER B 346
ALA B 343
VAL B  76
ILE B 203
 PLP  B 400 ( 4.1A)
PLP  B 400 ( 3.8A)
None
None
 0.76A 3a2qA-1wdwB:
0.0		 3a2qA-1wdwB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 TYR B 319
GLY B 228
GLY B 305
HIS B 110
SER B 230
 None
PLP  B 400 (-4.0A)
None
None
PLP  B 400 (-2.7A)
 1.23A 3dlcA-1wdwB:
2.3		 3dlcA-1wdwB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 8 ILE B 165
PRO B 302
VAL B 187
GLY B 188
 None
 0.92A 3em0B-1wdwB:
undetectable		 3em0B-1wdwB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 LYS B 208
GLN B 210
LEU B 212
GLU B 213
 None
 0.84A 3h5gB-1wdwB:
undetectable
3h5gC-1wdwB:
undetectable		 3h5gB-1wdwB:
6.67
3h5gC-1wdwB:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 10 ILE A 227
PRO A  16
LYS A 230
GLY A 231
LEU A 238
 None
 1.23A 3ik6B-1wdwA:
undetectable
3ik6E-1wdwA:
undetectable		 3ik6B-1wdwA:
22.43
3ik6E-1wdwA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 10 LEU A 238
ILE A 227
PRO A  16
LYS A 230
GLY A 231
 None
 1.24A 3ik6B-1wdwA:
undetectable
3ik6E-1wdwA:
undetectable		 3ik6B-1wdwA:
22.43
3ik6E-1wdwA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 HIS B 332
LEU B 299
ILE B 380
LEU B 370
 None
 0.90A 3kk6A-1wdwB:
undetectable		 3kk6A-1wdwB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 0.95A 3ndwA-1wdwB:
undetectable		 3ndwA-1wdwB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 10 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 1.04A 3nu6B-1wdwB:
undetectable		 3nu6B-1wdwB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 0.93A 3oxcA-1wdwB:
undetectable		 3oxcA-1wdwB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 9 TYR B  55
TYR B  69
ILE B 366
THR B  60
ILE B  63
 None
 1.28A 3p4wA-1wdwB:
0.0		 3p4wA-1wdwB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 11 VAL A 200
GLY A 220
TYR A  10
ALA A  32
LEU A 209
 None
 1.24A 3rc0A-1wdwA:
undetectable		 3rc0A-1wdwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLN B 109
GLY B 298
ILE B 341
ALA B 347
SER B 335
 PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
None
None
 1.13A 3sudB-1wdwB:
undetectable		 3sudB-1wdwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLN B 109
GLY B 298
ILE B 341
GLY B 372
ALA B 347
 PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
PLP  B 400 (-3.4A)
None
 0.99A 3sudB-1wdwB:
undetectable		 3sudB-1wdwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  88
ILE B 127
GLY B 118
ALA B 117
ALA B 113
 None
 1.05A 3sudB-1wdwB:
undetectable		 3sudB-1wdwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLN B 109
GLY B 298
ILE B 341
GLY B 372
ALA B 347
 PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
PLP  B 400 (-3.4A)
None
 1.02A 3sueA-1wdwB:
undetectable		 3sueA-1wdwB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 1.01A 3tkgD-1wdwB:
undetectable		 3tkgD-1wdwB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		4 / 8 TYR A  10
VAL A  84
ILE A  83
ILE A  71
 None
 0.69A 3uqbA-1wdwA:
undetectable		 3uqbA-1wdwA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 ILE B 165
LEU B 169
LEU B  19
HIS B 275
TYR B 301
 None
 1.49A 3vn2A-1wdwB:
0.0		 3vn2A-1wdwB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 TRP B 172
LEU B  22
ILE B 183
ILE B 195
TYR B 301
 None
 1.23A 4a79B-1wdwB:
0.7		 4a79B-1wdwB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 231
LEU A  59
HIS A  55
GLY A  62
ASP A  17
 None
 1.18A 4blvB-1wdwA:
undetectable		 4blvB-1wdwA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 10 ARG A  76
GLY A 111
ALA A  34
VAL A  84
VAL A 137
 None
 1.31A 4da7A-1wdwA:
undetectable		 4da7A-1wdwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 11 ALA B 103
GLY B 130
GLY B 106
ILE B 127
ASP B 133
 None
 1.13A 4dcmA-1wdwB:
undetectable		 4dcmA-1wdwB:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 ALA B 232
GLY B 305
PRO B 306
VAL B 186
 None
 0.95A 4dubB-1wdwB:
undetectable		 4dubB-1wdwB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 8 GLY B   7
GLY B 188
VAL B  11
TYR B  10
 None
 0.92A 4fgzA-1wdwB:
undetectable		 4fgzA-1wdwB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 8 GLY B   7
GLY B 188
VAL B  11
TYR B  10
 None
 0.92A 4fgzB-1wdwB:
undetectable		 4fgzB-1wdwB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 LEU B 311
VAL B 186
VAL B 226
PRO B 193
PRO B 306
 None
None
PLP  B 400 ( 4.5A)
None
None
 1.47A 4id5A-1wdwB:
0.5		 4id5A-1wdwB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 LEU B 311
VAL B 186
VAL B 226
PRO B 193
PRO B 306
 None
None
PLP  B 400 ( 4.5A)
None
None
 1.45A 4ifvA-1wdwB:
0.8		 4ifvA-1wdwB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 LEU B 311
VAL B 186
VAL B 226
PRO B 193
PRO B 306
 None
None
PLP  B 400 ( 4.5A)
None
None
 1.49A 4ifyA-1wdwB:
0.8		 4ifyA-1wdwB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 7 VAL B 196
ILE B 195
LEU B  15
LEU B  19
 None
 0.74A 4l1wA-1wdwB:
1.1		 4l1wA-1wdwB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		4 / 6 ARG A 185
ALA A 186
ASP A 146
LEU A 162
 None
 0.89A 4ot2A-1wdwA:
undetectable		 4ot2A-1wdwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.21A 4p6xA-1wdwB:
undetectable		 4p6xA-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.20A 4p6xE-1wdwB:
1.1		 4p6xE-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.22A 4p6xG-1wdwB:
undetectable		 4p6xG-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.23A 4p6xI-1wdwB:
1.1		 4p6xI-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.15A 4p6xK-1wdwB:
undetectable		 4p6xK-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 276
ILE B 289
VAL B 271
VAL A 114
ILE A  92
 None
 0.92A 4q5mA-1wdwB:
undetectable		 4q5mA-1wdwB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B 305
ILE B 183
SER B 185
LEU B 278
HIS B 275
 None
None
PLP  B 400 (-3.0A)
None
None
 1.02A 4qdjA-1wdwB:
2.1		 4qdjA-1wdwB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 9 ALA B 296
SER B 335
GLY B 374
ALA B 343
VAL B 350
 None
None
None
PLP  B 400 ( 3.8A)
None
 1.19A 4r1zA-1wdwB:
undetectable		 4r1zA-1wdwB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 ALA B  90
GLY B 118
GLU B 104
ALA B 168
TYR B 181
 None
 1.29A 4r29B-1wdwB:
undetectable		 4r29B-1wdwB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 7 LEU A 210
LEU A 246
LEU A 245
ARG A 203
ILE A   8
 None
 1.21A 4ubsA-1wdwA:
undetectable		 4ubsA-1wdwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 7 VAL B 196
ILE B 195
LEU B  15
LEU B  19
 None
 0.73A 4xo7A-1wdwB:
undetectable		 4xo7A-1wdwB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 10 ARG A 185
ALA A 186
ASP A 146
LEU A 162
ALA A 140
 None
 0.95A 4zbrA-1wdwA:
undetectable		 4zbrA-1wdwA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 7 PHE B 274
ASP A  43
ILE B 289
GLY B 287
 None
 1.13A 4zxiA-1wdwB:
2.1		 4zxiA-1wdwB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 GLY B 374
ASP B 375
ARG B 373
GLY B 372
 None
None
None
PLP  B 400 (-3.4A)
 0.80A 5cdnA-1wdwB:
undetectable
5cdnB-1wdwB:
undetectable		 5cdnA-1wdwB:
20.20
5cdnB-1wdwB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		4 / 6 ASP A  17
ARG A 232
GLY A 231
GLU A 233
 None
 1.02A 5cdqA-1wdwA:
undetectable
5cdqC-1wdwA:
undetectable
5cdqD-1wdwA:
undetectable		 5cdqA-1wdwA:
21.21
5cdqC-1wdwA:
21.21
5cdqD-1wdwA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 7 ALA B 164
GLY B 130
SER B 158
GLY B 157
 None
 0.88A 5e26A-1wdwB:
2.0
5e26B-1wdwB:
undetectable		 5e26A-1wdwB:
22.43
5e26B-1wdwB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		5 / 11 THR A  12
LEU A  22
PRO A  40
ALA A  68
ILE A  39
 None
 1.25A 5ewjA-1wdwA:
2.1
5ewjB-1wdwA:
undetectable		 5ewjA-1wdwA:
21.27
5ewjB-1wdwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 GLY B 228
SER B 185
VAL B 186
HIS B  81
 PLP  B 400 (-4.0A)
PLP  B 400 (-3.0A)
None
PLP  B 400 (-3.9A)
 1.05A 5ewuA-1wdwB:
3.1		 5ewuA-1wdwB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 GLY B 228
SER B 185
VAL B 186
HIS B  81
 PLP  B 400 (-4.0A)
PLP  B 400 (-3.0A)
None
PLP  B 400 (-3.9A)
 1.06A 5ewuB-1wdwB:
2.6		 5ewuB-1wdwB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY A 111
PHE B 274
PHE A  41
GLY B 287
PHE A 125
 None
 1.22A 5fsaB-1wdwA:
undetectable		 5fsaB-1wdwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 7 GLY B 111
THR B 114
VAL B 125
ASP B 126
ILE B 102
 None
 1.49A 5ik1A-1wdwB:
undetectable		 5ik1A-1wdwB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		3 / 3 VAL B 368
HIS B 348
VAL B 250
 None
 0.64A 5jmnC-1wdwB:
undetectable		 5jmnC-1wdwB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Pyrococcus
furiosus) 		3 / 3 LYS A  18
LEU A  59
ILE A  39
 None
 0.57A 5kc4A-1wdwA:
undetectable		 5kc4A-1wdwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 8 ILE B 367
ALA B 207
ALA B 214
GLU B 215
 None
 0.68A 5mvmA-1wdwB:
undetectable
5mvmB-1wdwB:
undetectable		 5mvmA-1wdwB:
12.95
5mvmB-1wdwB:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 VAL B 304
HIS B 308
LEU B 311
SER B 279
PRO B 193
 None
 1.32A 5nd4B-1wdwB:
undetectable		 5nd4B-1wdwB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 PHE B  95
ALA B  86
TRP B  46
ALA B  90
GLY B  88
 None
 1.20A 5tzoA-1wdwB:
undetectable		 5tzoA-1wdwB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 PHE B  95
ALA B  86
TRP B  46
ALA B  90
GLY B  88
 None
 1.18A 5tzoC-1wdwB:
undetectable		 5tzoC-1wdwB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		3 / 3 LYS B 290
PRO B 291
LYS B 261
 None
 1.21A 5y9yA-1wdwB:
undetectable		 5y9yA-1wdwB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		3 / 3 ASN B 369
VAL B 322
HIS B 348
 None
 0.82A 6a5yD-1wdwB:
undetectable		 6a5yD-1wdwB:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLN B 109
GLY B 298
ILE B 341
GLY B 372
ALA B 347
 PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
PLP  B 400 (-3.4A)
None
 1.08A 6c2mB-1wdwB:
undetectable		 6c2mB-1wdwB:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 GLY B  65
ALA B  66
VAL B 221
VAL B 368
ILE B 366
 None
 0.94A 6difB-1wdwB:
undetectable		 6difB-1wdwB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 12 LEU B 169
GLY B 188
VAL B  11
LEU B  15
ILE B  16
 None
 0.94A 6ecxA-1wdwB:
undetectable		 6ecxA-1wdwB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		5 / 10 VAL B 350
ALA B 353
LEU B 370
LEU B  59
LEU B 334
 None
 0.93A 6f5uA-1wdwB:
undetectable
6f5uB-1wdwB:
undetectable		 6f5uA-1wdwB:
12.61
6f5uB-1wdwB:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1
(Pyrococcus
furiosus) 		4 / 6 ARG B 170
ALA A  46
LEU B 169
ALA B 168
 None
 1.16A 6fosB-1wdwB:
undetectable		 6fosB-1wdwB:
11.63