SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 10 ALA A 128
PHE A 129
ALA A 133
LEU A 187
LEU A 108
 None
 1.03A 2bxqA-1wdyA:
undetectable		 2bxqA-1wdyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 6 THR A  94
LEU A 144
ASN A 119
LEU A 153
 None
 1.19A 4nc3A-1wdyA:
undetectable		 4nc3A-1wdyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		3 / 3 ASP A 189
HIS A 228
LYS A 185
 None
 1.01A 4qzuD-1wdyA:
undetectable		 4qzuD-1wdyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 11 ALA A 171
LEU A 187
LEU A 188
ILE A 221
GLY A 179
 None
 1.21A 5dxbB-1wdyA:
undetectable		 5dxbB-1wdyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.71A 5vkqA-1wdyA:
23.9
5vkqD-1wdyA:
15.6		 5vkqA-1wdyA:
10.93
5vkqD-1wdyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.70A 5vkqA-1wdyA:
23.9
5vkqB-1wdyA:
17.0		 5vkqA-1wdyA:
10.93
5vkqB-1wdyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.69A 5vkqB-1wdyA:
17.0
5vkqC-1wdyA:
17.0		 5vkqB-1wdyA:
10.93
5vkqC-1wdyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.70A 5vkqC-1wdyA:
17.0
5vkqD-1wdyA:
15.6		 5vkqC-1wdyA:
10.93
5vkqD-1wdyA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 1wdy 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 8 LYS A 137
LYS A 139
LEU A 108
GLU A 131
 None
None
None
25A  A1001 (-2.7A)
 0.76A 6mdqA-1wdyA:
0.5		 6mdqA-1wdyA:
14.61