SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1weh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 10 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.30A 1fk9A-1wehA:
undetectable		 1fk9A-1wehA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 11 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.38A 1fkpA-1wehA:
undetectable		 1fkpA-1wehA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 10 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.37A 1lw0A-1wehA:
undetectable		 1lw0A-1wehA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 11 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.37A 1lwcA-1wehA:
undetectable		 1lwcA-1wehA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 10 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.41A 1s1uA-1wehA:
undetectable		 1s1uA-1wehA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 9 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.33A 1vrtA-1wehA:
0.0		 1vrtA-1wehA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 10 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.36A 2hndA-1wehA:
0.0		 2hndA-1wehA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 10 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.37A 2hnyA-1wehA:
undetectable		 2hnyA-1wehA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		4 / 8 ARG A  50
GLY A  51
ALA A  54
LYS A  55
 None
 0.89A 2xfsA-1wehA:
undetectable		 2xfsA-1wehA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		4 / 8 ARG A  50
GLY A  51
ALA A  54
LYS A  55
 None
 0.81A 2xh9A-1wehA:
undetectable		 2xh9A-1wehA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		4 / 6 LEU A  48
GLY A  43
LEU A  36
CYH A  38
 None
 0.84A 3aiaA-1wehA:
2.9		 3aiaA-1wehA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 12 LEU A   4
LEU A  36
GLY A  35
VAL A  28
MET A   1
 None
 1.01A 4ok1A-1wehA:
undetectable		 4ok1A-1wehA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 12 LEU A   4
LEU A  36
GLY A  35
VAL A  28
MET A   1
 None
 1.03A 4oktA-1wehA:
undetectable		 4oktA-1wehA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 12 LEU A   4
LEU A  36
GLY A  35
VAL A  28
MET A   1
 None
 1.00A 4olmA-1wehA:
undetectable		 4olmA-1wehA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		4 / 8 LEU A   4
VAL A  28
VAL A  52
TYR A  25
 None
 1.02A 4puoC-1wehA:
undetectable		 4puoC-1wehA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		4 / 8 LEU A   4
VAL A  28
VAL A  52
TYR A  25
 None
 0.99A 4pwdA-1wehA:
undetectable		 4pwdA-1wehA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		3 / 5 GLY A 106
GLY A 109
GLU A 113
 None
 0.48A 4z2eA-1wehA:
undetectable
4z2eD-1wehA:
undetectable		 4z2eA-1wehA:
16.46
4z2eD-1wehA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 8 LEU A  36
GLY A  35
VAL A  52
ALA A  49
GLY A  61
 None
 1.11A 4zauA-1wehA:
undetectable		 4zauA-1wehA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		4 / 8 GLY A  92
LEU A  95
VAL A 127
LEU A 120
 None
 0.71A 6czmD-1wehA:
undetectable
6czmF-1wehA:
undetectable		 6czmD-1wehA:
21.33
6czmF-1wehA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		5 / 8 GLY A 139
LEU A 140
VAL A 115
VAL A 152
LEU A 111
 None
 1.47A 6czmD-1wehA:
undetectable
6czmF-1wehA:
undetectable		 6czmD-1wehA:
21.33
6czmF-1wehA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887
(Thermus
thermophilus) 		3 / 3 LEU A  97
LEU A  82
ARG A  93
 None
 0.67A 6fgcA-1wehA:
undetectable		 6fgcA-1wehA:
20.09