SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.84A 1fbmB-1wekA:
undetectable		 1fbmB-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.54A 1fbmD-1wekA:
undetectable		 1fbmD-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 5 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.69A 1fbmE-1wekA:
undetectable		 1fbmE-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.99A 1mz9D-1wekA:
undetectable		 1mz9D-1wekA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		3 / 3 THR A 144
LEU A 148
VAL A 151
 PO4  A 501 (-3.9A)
None
None
 0.38A 1mz9E-1wekA:
undetectable		 1mz9E-1wekA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 4 SER A  41
VAL A  84
PHE A 137
VAL A 165
 None
 1.14A 1o86A-1wekA:
undetectable		 1o86A-1wekA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		5 / 12 ALA A  54
GLY A  58
ASN A  85
LEU A  61
PRO A 139
 None
 0.90A 2f8lA-1wekA:
2.7		 2f8lA-1wekA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		3 / 3 LEU A 138
PRO A 139
ARG A  60
 None
 0.66A 2qd5A-1wekA:
3.2		 2qd5A-1wekA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		5 / 11 ALA A  57
VAL A  84
GLY A  62
ALA A  64
LEU A 168
 None
 0.86A 3sm2B-1wekA:
undetectable		 3sm2B-1wekA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 7 GLY A  77
MET A  81
ASN A  85
GLU A 105
 None
 1.03A 4fgkB-1wekA:
6.3		 4fgkB-1wekA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		5 / 6 THR A  31
GLY A  28
GLU A  27
PHE A  29
ILE A  21
 None
 1.45A 5kmfA-1wekA:
undetectable
5kmfC-1wekA:
undetectable		 5kmfA-1wekA:
20.70
5kmfC-1wekA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 8 THR A 144
TRP A 173
TYR A 172
PHE A  48
 PO4  A 501 (-3.9A)
None
None
None
 1.27A 5v4vA-1wekA:
undetectable		 5v4vA-1wekA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1wek HYPOTHETICAL PROTEIN
TT1465
(Thermus
thermophilus) 		4 / 8 THR A 144
TRP A 173
TYR A 172
PHE A  48
 PO4  A 501 (-3.9A)
None
None
None
 1.27A 5v4vB-1wekA:
undetectable		 5v4vB-1wekA:
21.18