SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UXP_A_CLMA1211_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR)	1wel	RNA-BINDING PROTEIN 12 (Homo sapiens)	5 / 8	LEU A 437 LEU A 434 ILE A 460 VAL A 432 ILE A 505	None	1.39A	2uxpA-1welA: undetectable	2uxpA-1welA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_E_SAME301_0 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	1wel	RNA-BINDING PROTEIN 12 (Homo sapiens)	5 / 12	ALA A 470 GLY A 436 GLY A 472 GLY A 474 LEU A 434	None	0.77A	5c0oE-1welA: undetectable	5c0oE-1welA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_G_SAMG301_0 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	1wel	RNA-BINDING PROTEIN 12 (Homo sapiens)	5 / 12	ALA A 470 GLY A 436 GLY A 472 GLY A 474 LEU A 434	None	0.85A	5c0oG-1welA: undetectable	5c0oG-1welA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZVG_B_SAMB401_0 (389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN)	1wel	RNA-BINDING PROTEIN 12 (Homo sapiens)	5 / 12	ALA A 463 PRO A 466 GLY A 468 TYR A 433 PHE A 475	None	1.35A	5zvgB-1welA: undetectable	5zvgB-1welA: 15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_C_ACTC609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	1wel	RNA-BINDING PROTEIN 12 (Homo sapiens)	4 / 5	PHE A 430 GLU A 477 PHE A 478 ASP A 483	None	1.40A	6b58C-1welA: 0.0	6b58C-1welA: 10.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2UXP_A_CLMA1211_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR","1wel","RNA-BINDING PROTEIN 12","Homo sapiens",5,"LEU A 437;LEU A 434;ILE A 460;VAL A 432;ILE A 505","None","1.39A","2uxpA-1welA:undetectable","2uxpA-1welA:20.47"],["5C0O_E_SAME301_0","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRMI","1wel","RNA-BINDING PROTEIN 12","Homo sapiens",5,"ALA A 470;GLY A 436;GLY A 472;GLY A 474;LEU A 434","None","0.77A","5c0oE-1welA:undetectable","5c0oE-1welA:18.37"],["5C0O_G_SAMG301_0","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRMI","1wel","RNA-BINDING PROTEIN 12","Homo sapiens",5,"ALA A 470;GLY A 436;GLY A 472;GLY A 474;LEU A 434","None","0.85A","5c0oG-1welA:undetectable","5c0oG-1welA:18.37"],["5ZVG_B_SAMB401_0","389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN","1wel","RNA-BINDING PROTEIN 12","Homo sapiens",5,"ALA A 463;PRO A 466;GLY A 468;TYR A 433;PHE A 475","None","1.35A","5zvgB-1welA:undetectable","5zvgB-1welA:15.53"],["6B58_C_ACTC609_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","1wel","RNA-BINDING PROTEIN 12","Homo sapiens",4,"PHE A 430;GLU A 477;PHE A 478;ASP A 483","None","1.40A","6b58C-1welA:0.0","6b58C-1welA:10.95"]]