SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)
1wer P120GAP
(Homo
sapiens)
4 / 6 PHE A 860
GLU A 973
LEU A 974
VAL A 900
None
0.99A 1hk1A-1werA:
0.0
1hk1A-1werA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)
1wer P120GAP
(Homo
sapiens)
4 / 7 PHE A 860
GLU A 973
LEU A 974
VAL A 900
None
0.91A 1hk2A-1werA:
undetectable
1hk2A-1werA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)
1wer P120GAP
(Homo
sapiens)
5 / 9 GLU A1000
ARG A 758
LEU A 751
ILE A 755
ASP A 994
None
1.45A 1nb9A-1werA:
undetectable
1nb9A-1werA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)
1wer P120GAP
(Homo
sapiens)
5 / 9 LEU A 752
HIS A 736
ALA A 740
LEU A1012
LEU A 729
None
1.47A 2azqA-1werA:
undetectable
2azqA-1werA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)
1wer P120GAP
(Homo
sapiens)
4 / 7 LEU A 787
GLU A 781
ASP A 782
THR A 792
None
1.18A 3dzgB-1werA:
undetectable
3dzgB-1werA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)
1wer P120GAP
(Homo
sapiens)
5 / 9 ILE A 821
LYS A 820
GLU A 854
LEU A 855
LYS A 858
None
1.14A 3f78A-1werA:
undetectable
3f78A-1werA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)
1wer P120GAP
(Homo
sapiens)
5 / 12 LEU A 819
LEU A 852
HIS A 847
ILE A 909
ALA A 934
None
1.03A 3uwlB-1werA:
undetectable
3uwlB-1werA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)
1wer P120GAP
(Homo
sapiens)
5 / 12 LEU A 819
LEU A 852
HIS A 847
ILE A 909
ALA A 934
None
1.01A 3uwlD-1werA:
undetectable
3uwlD-1werA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
1wer P120GAP
(Homo
sapiens)
3 / 3 ALA A 941
GLN A 878
GLY A 875
None
0.57A 4odoC-1werA:
undetectable
4odoC-1werA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1wer P120GAP
(Homo
sapiens)
5 / 8 LEU A 930
VAL A 933
ILE A 905
ALA A 908
LEU A 814
None
1.44A 4qrcA-1werA:
undetectable
4qrcA-1werA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)
1wer P120GAP
(Homo
sapiens)
5 / 11 SER A 817
ASP A 816
GLU A 854
PRO A 912
LEU A 930
None
1.37A 5jh7B-1werA:
undetectable
5jh7B-1werA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)
1wer P120GAP
(Homo
sapiens)
5 / 11 SER A 817
ASP A 816
GLU A 854
PRO A 912
LEU A 930
None
1.36A 5jh7D-1werA:
undetectable
5jh7D-1werA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)
1wer P120GAP
(Homo
sapiens)
3 / 3 LYS A 820
LEU A 930
ILE A 917
None
0.80A 5kc4A-1werA:
2.7
5kc4A-1werA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)
1wer P120GAP
(Homo
sapiens)
4 / 6 ARG A 776
CYH A1002
THR A1030
PHE A 726
None
1.42A 5mwyA-1werA:
undetectable
5mwyA-1werA:
23.63