SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wf3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 5 HIS A  98
SER A 153
LEU A 155
GLY A  19
 None
GNP  A 501 (-2.7A)
GNP  A 501 ( 4.4A)
GNP  A 501 (-3.4A)
 1.09A 1a4lB-1wf3A:
undetectable		 1a4lB-1wf3A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 296
LEU A 197
LEU A 294
TRP A 284
 GOL  A 602 (-4.5A)
None
None
None
 1.12A 1i7zA-1wf3A:
undetectable		 1i7zA-1wf3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 VAL A  93
VAL A  91
ILE A  57
LEU A 163
 None
 0.85A 1igxA-1wf3A:
undetectable		 1igxA-1wf3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 SER A   7
ILE A  49
GLY A  53
ARG A  54
 None
 0.83A 1meiA-1wf3A:
undetectable		 1meiA-1wf3A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 ILE A 256
ILE A 253
VAL A 278
ALA A 232
LEU A 197
 None
 1.03A 2m9qA-1wf3A:
undetectable		 2m9qA-1wf3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A 236
LEU A 205
VAL A 245
ILE A 256
THR A 260
 None
 1.12A 3frqA-1wf3A:
undetectable		 3frqA-1wf3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A  96
PRO A 133
LEU A 127
ARG A 150
 None
 1.24A 3hcoB-1wf3A:
3.7		 3hcoB-1wf3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 297
GLU A 289
TYR A 281
 None
 0.81A 3k37B-1wf3A:
undetectable		 3k37B-1wf3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 8 GLY A  19
ALA A 136
MET A 137
ASP A 128
LEU A 127
 GNP  A 501 (-3.4A)
None
None
GNP  A 501 (-2.9A)
None
 1.45A 4l9iB-1wf3A:
undetectable		 4l9iB-1wf3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A 196
THR A 260
ALA A 232
LEU A 264
LEU A 274
 None
 1.34A 4pbhA-1wf3A:
undetectable		 4pbhA-1wf3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 150
GLN A 159
GLU A 162
 None
 0.93A 4tvtA-1wf3A:
undetectable		 4tvtA-1wf3A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 163
VAL A 160
LEU A  50
GLY A  29
LEU A  24
 None
 1.35A 4zbqA-1wf3A:
undetectable		 4zbqA-1wf3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 ILE A 120
ALA A  11
VAL A  13
VAL A 118
 None
 0.90A 5ecnD-1wf3A:
4.9		 5ecnD-1wf3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 THR A 188
GLY A 190
GLU A 191
ILE A 233
 None
None
GOL  A 602 ( 4.9A)
None
 0.95A 5kmfA-1wf3A:
undetectable
5kmfC-1wf3A:
undetectable		 5kmfA-1wf3A:
22.70
5kmfC-1wf3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A 273
ALA A 232
LEU A 276
 None
 0.63A 6ag0C-1wf3A:
2.2		 6ag0C-1wf3A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 5 ARG A 204
ALA A 201
GLN A 263
ILE A 196
 None
 1.38A 6g9bA-1wf3A:
undetectable
6g9bB-1wf3A:
undetectable		 6g9bA-1wf3A:
15.59
6g9bB-1wf3A:
13.76