SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_A_ACTA3003_0 (BETA-CARBONIC ANHYDRASE)	1wfk	ZINC FINGER, FYVE DOMAIN CONTAINING 19 (Mus musculus)	4 / 8	CYH A 12 VAL A 17 CYH A 39 GLY A 38	ZN A 200 (-2.3A) None ZN A 200 (-2.2A) None	0.84A	1ekjA-1wfkA: undetectable 1ekjB-1wfkA: undetectable	1ekjA-1wfkA: 17.89 1ekjB-1wfkA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GEH_A_NHYA300_1 (CARBONIC ANHYDRASE 2)	1wfk	ZINC FINGER, FYVE DOMAIN CONTAINING 19 (Mus musculus)	4 / 8	HIS A 61 VAL A 56 LEU A 64 THR A 65	None	0.71A	2gehA-1wfkA: undetectable	2gehA-1wfkA: 13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_A_CHDA3_0 (FERROCHELATASE)	1wfk	ZINC FINGER, FYVE DOMAIN CONTAINING 19 (Mus musculus)	3 / 3	PRO A 47 LEU A 64 ARG A 66	None	0.75A	3aqiA-1wfkA: undetectable	3aqiA-1wfkA: 13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB5_0 (FERROCHELATASE)	1wfk	ZINC FINGER, FYVE DOMAIN CONTAINING 19 (Mus musculus)	3 / 3	PRO A 47 LEU A 64 ARG A 66	None	0.78A	3aqiB-1wfkA: undetectable	3aqiB-1wfkA: 13.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_A_ACTA3003_0","BETA-CARBONIC ANHYDRASE","1wfk","ZINC FINGER, FYVE DOMAIN CONTAINING 19","Mus musculus",4,"CYH A  12;VAL A  17;CYH A  39;GLY A  38"," ZN A 200 (-2.3A);None; ZN A 200 (-2.2A);None","0.84A","1ekjA-1wfkA:undetectable;1ekjB-1wfkA:undetectable","1ekjA-1wfkA:17.89;1ekjB-1wfkA:17.89"],["2GEH_A_NHYA300_1","CARBONIC ANHYDRASE 2","1wfk","ZINC FINGER, FYVE DOMAIN CONTAINING 19","Mus musculus",4,"HIS A  61;VAL A  56;LEU A  64;THR A  65","None","0.71A","2gehA-1wfkA:undetectable","2gehA-1wfkA:13.85"],["3AQI_A_CHDA3_0","FERROCHELATASE","1wfk","ZINC FINGER, FYVE DOMAIN CONTAINING 19","Mus musculus",3,"PRO A  47;LEU A  64;ARG A  66","None","0.75A","3aqiA-1wfkA:undetectable","3aqiA-1wfkA:13.35"],["3AQI_B_CHDB5_0","FERROCHELATASE","1wfk","ZINC FINGER, FYVE DOMAIN CONTAINING 19","Mus musculus",3,"PRO A  47;LEU A  64;ARG A  66","None","0.78A","3aqiB-1wfkA:undetectable","3aqiB-1wfkA:13.35"]]