SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		3 / 3 TRP A 168
VAL A 169
PRO A 170
 None
 0.85A 1rh0A-1wfxA:
undetectable		 1rh0A-1wfxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 8 LEU A  94
VAL A 119
ILE A 111
VAL A 169
LEU A 149
 None
 1.34A 3kp6A-1wfxA:
3.2
3kp6B-1wfxA:
4.4		 3kp6A-1wfxA:
20.69
3kp6B-1wfxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 7 ARG A  26
THR A  25
GLY A  28
VAL A  83
 None
 0.92A 4qwpB-1wfxA:
undetectable		 4qwpB-1wfxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 ALA A 140
LEU A 138
SER A 181
VAL A 177
 None
 1.02A 5a6iA-1wfxA:
undetectable		 5a6iA-1wfxA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		3 / 3 VAL A 166
LEU A 103
MET A 107
 None
 0.88A 5ikrA-1wfxA:
undetectable		 5ikrA-1wfxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 ASP A  59
TYR A  75
ASP A 127
GLU A 126
 None
 1.11A 6mn5A-1wfxA:
undetectable		 6mn5A-1wfxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 7 ASP A  59
TYR A  75
ASP A 127
GLU A 126
 None
 1.07A 6mn5B-1wfxA:
undetectable		 6mn5B-1wfxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 ASP A  59
TYR A  75
ASP A 127
GLU A 126
 None
 1.02A 6mn5C-1wfxA:
undetectable		 6mn5C-1wfxA:
20.50