SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1wfy RAP1/RAP2
INTERACTING PROTEIN
REGULATOR OF
G-PROTEIN SIGNALING
14
(Mus
musculus) 		5 / 12 GLU A  65
LEU A  85
VAL A  78
LEU A  40
LEU A  44
 None
 1.01A 1sn5B-1wfyA:
undetectable
1sn5D-1wfyA:
undetectable		 1sn5B-1wfyA:
19.23
1sn5D-1wfyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1wfy RAP1/RAP2
INTERACTING PROTEIN
REGULATOR OF
G-PROTEIN SIGNALING
14
(Mus
musculus) 		5 / 12 LEU A  40
LEU A  44
GLU A  65
LEU A  85
VAL A  78
 None
 1.02A 1sn5B-1wfyA:
undetectable
1sn5D-1wfyA:
undetectable		 1sn5B-1wfyA:
19.23
1sn5D-1wfyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 1wfy RAP1/RAP2
INTERACTING PROTEIN
REGULATOR OF
G-PROTEIN SIGNALING
14
(Mus
musculus) 		4 / 5 SER A  33
ARG A  16
PRO A  36
VAL A  75
 None
 1.39A 3sufC-1wfyA:
undetectable		 3sufC-1wfyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1wfy REGULATOR OF
G-PROTEIN SIGNALING
14
RAP1/RAP2
INTERACTING PROTEIN
(Mus
musculus) 		4 / 5 PHE A  19
PRO A  36
VAL A  75
ALA A  79
 None
 1.34A 4w5oA-1wfyA:
undetectable		 4w5oA-1wfyA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1wfy REGULATOR OF
G-PROTEIN SIGNALING
14
RAP1/RAP2
INTERACTING PROTEIN
(Mus
musculus) 		4 / 5 PHE A  19
PRO A  36
VAL A  75
ALA A  79
 None
 1.33A 4z4cA-1wfyA:
undetectable		 4z4cA-1wfyA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1wfy REGULATOR OF
G-PROTEIN SIGNALING
14
RAP1/RAP2
INTERACTING PROTEIN
(Mus
musculus) 		4 / 5 PHE A  19
PRO A  36
VAL A  75
ALA A  79
 None
 1.32A 4z4eA-1wfyA:
undetectable		 4z4eA-1wfyA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1wfy REGULATOR OF
G-PROTEIN SIGNALING
14
RAP1/RAP2
INTERACTING PROTEIN
(Mus
musculus) 		3 / 3 PRO A  74
SER A  76
SER A  77
 None
 0.65A 6bpyA-1wfyA:
undetectable		 6bpyA-1wfyA:
16.06