SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 142
VAL A 181
LEU A 177
ALA A 165
 None
 0.95A 1fiqC-1wg8A:
undetectable		 1fiqC-1wg8A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.99A 1mt1A-1wg8A:
undetectable
1mt1F-1wg8A:
undetectable		 1mt1A-1wg8A:
13.25
1mt1F-1wg8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ARG A 271
LEU A  94
ASP A  96
LEU A  97
 SAM  A3142 (-3.2A)
None
SAM  A3142 (-3.5A)
None
 0.96A 1mt1B-1wg8A:
undetectable
1mt1C-1wg8A:
undetectable		 1mt1B-1wg8A:
19.43
1mt1C-1wg8A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ARG A 271
LEU A  94
ASP A  96
LEU A  97
 SAM  A3142 (-3.2A)
None
SAM  A3142 (-3.5A)
None
 1.01A 1n13B-1wg8A:
undetectable
1n13C-1wg8A:
undetectable		 1n13B-1wg8A:
19.43
1n13C-1wg8A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 1.00A 1n13I-1wg8A:
undetectable
1n13L-1wg8A:
undetectable		 1n13I-1wg8A:
13.25
1n13L-1wg8A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 THR A  30
GLY A  32
GLY A  35
ASP A  53
ARG A 271
 SAM  A3142 (-3.8A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
None
SAM  A3142 (-3.2A)
 0.28A 1n2xA-1wg8A:
37.1		 1n2xA-1wg8A:
48.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 THR A  30
GLY A  32
GLY A  35
HIS A  36
ASP A  53
GLY A  98
 SAM  A3142 (-3.8A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
SAM  A3142 (-3.9A)
None
SAM  A3142 (-4.6A)
 0.57A 1n2xB-1wg8A:
34.8		 1n2xB-1wg8A:
48.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 THR A  30
GLY A  32
GLY A  35
HIS A  36
GLY A  98
ASN A  74
 SAM  A3142 (-3.8A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
SAM  A3142 (-3.9A)
SAM  A3142 (-4.6A)
SAM  A3142 (-3.0A)
 1.32A 1n2xB-1wg8A:
34.8		 1n2xB-1wg8A:
48.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		12 / 12 PRO A   8
THR A  30
GLY A  32
GLY A  33
GLY A  35
GLN A  52
ASP A  53
PHE A  75
SER A 100
HIS A 103
MET A 123
ARG A 271
 SAM  A3142 (-4.1A)
SAM  A3142 (-3.8A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
SAM  A3142 (-3.9A)
None
SAM  A3142 (-3.2A)
SAM  A3142 (-4.1A)
SAM  A3142 (-4.4A)
SAM  A3142 (-3.5A)
SAM  A3142 (-3.2A)
 0.05A 1wg8A-1wg8A:
49.9		 1wg8A-1wg8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 4 HIS A  36
ASP A  51
ASN A  74
ASP A  96
 SAM  A3142 (-3.9A)
SAM  A3142 (-2.8A)
SAM  A3142 (-3.0A)
SAM  A3142 (-3.5A)
 0.00A 1wg8A-1wg8A:
49.9		 1wg8A-1wg8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 PRO A   8
GLY A  32
GLY A  33
GLY A  35
SER A 101
 SAM  A3142 (-4.1A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
None
 0.90A 1wg8B-1wg8A:
45.8		 1wg8B-1wg8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		12 / 12 PRO A   8
THR A  30
GLY A  32
GLY A  33
GLY A  35
GLN A  52
ASP A  53
PHE A  75
ASP A  96
SER A 100
HIS A 103
MET A 123
 SAM  A3142 (-4.1A)
SAM  A3142 (-3.8A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
SAM  A3142 (-3.9A)
None
SAM  A3142 (-3.2A)
SAM  A3142 (-3.5A)
SAM  A3142 (-4.1A)
SAM  A3142 (-4.4A)
SAM  A3142 (-3.5A)
 0.47A 1wg8B-1wg8A:
45.8		 1wg8B-1wg8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 HIS A  36
ASP A  51
ASN A  74
 SAM  A3142 (-3.9A)
SAM  A3142 (-2.8A)
SAM  A3142 (-3.0A)
 0.15A 1wg8B-1wg8A:
45.8		 1wg8B-1wg8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 GLU A 151
ALA A 200
LEU A 201
GLU A 208
LEU A 209
 None
 1.14A 2azqA-1wg8A:
undetectable		 2azqA-1wg8A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 216
VAL A  27
ALA A  29
LEU A  94
LEU A 229
 None
 1.35A 2c12F-1wg8A:
undetectable		 2c12F-1wg8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ASP A 106
ARG A 109
ASP A 120
ASP A  53
 None
 1.16A 2j2pE-1wg8A:
undetectable
2j2pF-1wg8A:
undetectable		 2j2pE-1wg8A:
21.60
2j2pF-1wg8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ILE A 162
ILE A 158
ARG A 195
ILE A 171
 None
 0.69A 2nniA-1wg8A:
undetectable		 2nniA-1wg8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.21A 2obvA-1wg8A:
undetectable		 2obvA-1wg8A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.21A 2p02A-1wg8A:
undetectable		 2p02A-1wg8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A  97
LEU A 246
PHE A  75
 None
None
SAM  A3142 (-3.2A)
 0.72A 2pgrA-1wg8A:
undetectable		 2pgrA-1wg8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ASP A 239
VAL A 242
PRO A 258
THR A 255
 None
 1.33A 2q6oB-1wg8A:
undetectable		 2q6oB-1wg8A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 ARG A 271
LEU A  94
ASP A  96
LEU A  97
 SAM  A3142 (-3.2A)
None
SAM  A3142 (-3.5A)
None
 0.99A 2qqcB-1wg8A:
undetectable
2qqcC-1wg8A:
undetectable		 2qqcB-1wg8A:
18.79
2qqcC-1wg8A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.98A 2qqcA-1wg8A:
undetectable
2qqcF-1wg8A:
undetectable		 2qqcA-1wg8A:
13.25
2qqcF-1wg8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.97A 2qqcG-1wg8A:
undetectable
2qqcJ-1wg8A:
undetectable		 2qqcG-1wg8A:
13.25
2qqcJ-1wg8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.97A 2qqcI-1wg8A:
undetectable
2qqcL-1wg8A:
undetectable		 2qqcI-1wg8A:
13.25
2qqcL-1wg8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.99A 2qqdA-1wg8A:
undetectable
2qqdE-1wg8A:
undetectable		 2qqdA-1wg8A:
13.65
2qqdE-1wg8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 229
VAL A 242
ILE A 232
ALA A 233
THR A  30
 None
None
None
None
SAM  A3142 (-3.8A)
 1.16A 3mdtA-1wg8A:
undetectable		 3mdtA-1wg8A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 THR A  30
GLY A  32
GLY A  35
HIS A  36
ASP A  53
PHE A  75
SER A 100
MET A 123
 SAM  A3142 (-3.8A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.1A)
SAM  A3142 (-3.9A)
None
SAM  A3142 (-3.2A)
SAM  A3142 (-4.1A)
SAM  A3142 (-3.5A)
 0.60A 3tkaA-1wg8A:
37.7		 3tkaA-1wg8A:
41.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.18A 4ndnA-1wg8A:
undetectable		 4ndnA-1wg8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.23A 4ndnC-1wg8A:
undetectable		 4ndnC-1wg8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 VAL A   7
SER A 262
ALA A 275
PHE A 234
 None
 1.13A 4nedA-1wg8A:
undetectable		 4nedA-1wg8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.23A 4odjA-1wg8A:
undetectable		 4odjA-1wg8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.22A 5a1iA-1wg8A:
undetectable		 5a1iA-1wg8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 GLY A  33
GLY A  32
HIS A  36
ASP A  96
 SAM  A3142 (-3.4A)
SAM  A3142 (-3.4A)
SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
 0.79A 5f8yB-1wg8A:
undetectable		 5f8yB-1wg8A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLY A  32
ASP A  51
ASN A  74
 SAM  A3142 (-3.4A)
SAM  A3142 (-2.8A)
SAM  A3142 (-3.0A)
 0.39A 5jglA-1wg8A:
16.3		 5jglA-1wg8A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 177
ILE A 171
LEU A 201
THR A 129
VAL A 134
 None
 0.92A 5twjD-1wg8A:
undetectable		 5twjD-1wg8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 8 VAL A  57
ASP A  51
GLN A  52
GLY A 124
LEU A 125
 None
SAM  A3142 (-2.8A)
SAM  A3142 (-3.9A)
None
None
 0.97A 5w3jB-1wg8A:
3.6		 5w3jB-1wg8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLY A  92
ASP A  28
GLY A  24
GLY A  45
 None
SAM  A3142 ( 4.9A)
None
None
 0.72A 6ag0C-1wg8A:
undetectable		 6ag0C-1wg8A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 HIS A  36
ASP A  96
SER A 274
PHE A 234
 SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
 1.21A 6g6rA-1wg8A:
undetectable		 6g6rA-1wg8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 226
ARG A 228
ALA A  19
LEU A  18
GLY A  92
 None
 1.40A 6hqbA-1wg8A:
undetectable
6hqbJ-1wg8A:
undetectable		 6hqbA-1wg8A:
14.08
6hqbJ-1wg8A:
9.47