SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens) 		4 / 4 LEU A  67
ILE A  58
ARG A  80
TRP A  81
 None
 1.43A 1ie9A-1wh0A:
0.0		 1ie9A-1wh0A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens) 		3 / 3 ASN A  22
PHE A  66
VAL A  20
 None
 0.85A 1kijA-1wh0A:
undetectable		 1kijA-1wh0A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens) 		3 / 3 ASN A  87
TRP A 115
GLN A 111
 None
 1.43A 1xoqA-1wh0A:
undetectable		 1xoqA-1wh0A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens) 		5 / 11 PHE A  66
VAL A  48
PHE A  55
VAL A  34
PHE A  59
 None
 1.50A 3u9fN-1wh0A:
undetectable
3u9fO-1wh0A:
undetectable		 3u9fN-1wh0A:
21.08
3u9fO-1wh0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens) 		4 / 5 CYH A  94
GLN A  93
PRO A  91
ILE A  89
 None
 1.22A 5ki6A-1wh0A:
undetectable		 5ki6A-1wh0A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens) 		4 / 5 ILE A 103
PHE A  98
ARG A  47
THR A  78
 None
 1.11A 5z84N-1wh0A:
undetectable
5z84W-1wh0A:
undetectable		 5z84N-1wh0A:
14.85
5z84W-1wh0A:
18.66