SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1whb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1whb KIAA0055
(Homo
sapiens) 		4 / 8 TYR A 142
THR A  27
TRP A 138
LEU A  33
 None
 1.46A 1uw6A-1whbA:
undetectable
1uw6B-1whbA:
undetectable		 1uw6A-1whbA:
18.92
1uw6B-1whbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1whb KIAA0055
(Homo
sapiens) 		4 / 8 TYR A 142
THR A  27
TRP A 138
LEU A  33
 None
 1.48A 1uw6G-1whbA:
undetectable
1uw6H-1whbA:
undetectable		 1uw6G-1whbA:
18.92
1uw6H-1whbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1whb KIAA0055
(Homo
sapiens) 		4 / 8 TRP A 138
LEU A  33
TYR A 142
THR A  27
 None
 1.48A 1uw6P-1whbA:
undetectable
1uw6T-1whbA:
undetectable		 1uw6P-1whbA:
18.92
1uw6T-1whbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1whb KIAA0055
(Homo
sapiens) 		5 / 9 LEU A 111
VAL A  64
ALA A 114
LEU A  53
MET A  36
 None
 1.36A 2qo5A-1whbA:
0.0		 2qo5A-1whbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1whb KIAA0055
(Homo
sapiens) 		3 / 3 ARG A 109
GLU A 132
SER A 110
 None
 0.91A 2xkkA-1whbA:
3.6
2xkkC-1whbA:
2.9		 2xkkA-1whbA:
11.99
2xkkC-1whbA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1whb KIAA0055
(Homo
sapiens) 		5 / 10 GLY A 134
TYR A 135
ILE A  35
LEU A  93
LEU A 131
 None
 1.15A 4xj7A-1whbA:
undetectable
4xj7B-1whbA:
undetectable		 4xj7A-1whbA:
20.45
4xj7B-1whbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1whb KIAA0055
(Homo
sapiens) 		5 / 10 LEU A  93
LEU A 131
GLY A 134
TYR A 135
ILE A  35
 None
 1.08A 4xj7C-1whbA:
undetectable
4xj7D-1whbA:
undetectable		 4xj7C-1whbA:
20.45
4xj7D-1whbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1whb KIAA0055
(Homo
sapiens) 		5 / 9 LEU A 111
ILE A  60
GLY A 105
LEU A  92
ALA A  38
 None
 0.97A 5o96A-1whbA:
undetectable
5o96B-1whbA:
undetectable		 5o96A-1whbA:
21.51
5o96B-1whbA:
21.51