SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1whu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9H_A_RAPA108_1 (FKBP12.6)	1whu	3'-5' RNA EXONUCLEASE POLYNUCLEOTIDE PHOSPHORYLASE (Mus musculus)	5 / 12	PHE A 349 VAL A 314 ILE A 317 ILE A 291 PHE A 341	None	1.18A	1c9hA-1whuA: undetectable	1c9hA-1whuA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK2_A_T44A3003_1 (SERUM ALBUMIN)	1whu	3'-5' RNA EXONUCLEASE POLYNUCLEOTIDE PHOSPHORYLASE (Mus musculus)	4 / 6	PHE A 341 ILE A 284 LYS A 289 ALA A 292	None	1.27A	1hk2A-1whuA: 2.3	1hk2A-1whuA: 10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRH_A_RAPA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5)	1whu	3'-5' RNA EXONUCLEASE POLYNUCLEOTIDE PHOSPHORYLASE (Mus musculus)	5 / 12	PHE A 349 VAL A 314 ILE A 317 ILE A 291 PHE A 341	None	1.25A	4drhA-1whuA: undetectable	4drhA-1whuA: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRJ_A_RAPA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4)	1whu	3'-5' RNA EXONUCLEASE POLYNUCLEOTIDE PHOSPHORYLASE (Mus musculus)	5 / 11	PHE A 349 VAL A 314 ILE A 317 ILE A 291 PHE A 341	None	1.27A	4drjA-1whuA: undetectable	4drjA-1whuA: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LAX_A_FK5A301_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4)	1whu	3'-5' RNA EXONUCLEASE POLYNUCLEOTIDE PHOSPHORYLASE (Mus musculus)	5 / 10	PHE A 349 VAL A 314 ILE A 317 ILE A 291 PHE A 341	None	1.23A	4laxA-1whuA: undetectable	4laxA-1whuA: 16.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C9H_A_RAPA108_1","FKBP12.6","1whu"," 3'-5' RNA EXONUCLEASE;POLYNUCLEOTIDE PHOSPHORYLASE","Mus musculus",5,"PHE A 349;VAL A 314;ILE A 317;ILE A 291;PHE A 341","None","1.18A","1c9hA-1whuA:undetectable","1c9hA-1whuA:22.50"],["1HK2_A_T44A3003_1","SERUM ALBUMIN","1whu"," 3'-5' RNA EXONUCLEASE;POLYNUCLEOTIDE PHOSPHORYLASE","Mus musculus",4,"PHE A 341;ILE A 284;LYS A 289;ALA A 292","None","1.27A","1hk2A-1whuA:2.3","1hk2A-1whuA:10.14"],["4DRH_A_RAPA201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5","1whu"," 3'-5' RNA EXONUCLEASE;POLYNUCLEOTIDE PHOSPHORYLASE","Mus musculus",5,"PHE A 349;VAL A 314;ILE A 317;ILE A 291;PHE A 341","None","1.25A","4drhA-1whuA:undetectable","4drhA-1whuA:19.58"],["4DRJ_A_RAPA201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4","1whu"," 3'-5' RNA EXONUCLEASE;POLYNUCLEOTIDE PHOSPHORYLASE","Mus musculus",5,"PHE A 349;VAL A 314;ILE A 317;ILE A 291;PHE A 341","None","1.27A","4drjA-1whuA:undetectable","4drjA-1whuA:22.82"],["4LAX_A_FK5A301_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4","1whu"," 3'-5' RNA EXONUCLEASE;POLYNUCLEOTIDE PHOSPHORYLASE","Mus musculus",5,"PHE A 349;VAL A 314;ILE A 317;ILE A 291;PHE A 341","None","1.23A","4laxA-1whuA:undetectable","4laxA-1whuA:16.97"]]