SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  21
TYR A 260
ASN A 151
TYR A 268
 None
 1.04A 1afsA-1wiwA:
undetectable		 1afsA-1wiwA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  21
TYR A 260
ASN A 151
TYR A 268
 None
 1.04A 1afsB-1wiwA:
undetectable		 1afsB-1wiwA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 ALA A 218
LEU A 220
LEU A 234
ALA A 230
 None
 0.81A 1e7cA-1wiwA:
undetectable		 1e7cA-1wiwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		6 / 11 LEU A 109
VAL A 186
TYR A 267
GLY A 278
TRP A 264
GLU A  20
 None
 1.48A 1jkhA-1wiwA:
undetectable
1jkhB-1wiwA:
undetectable		 1jkhA-1wiwA:
19.07
1jkhB-1wiwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A  97
GLY A  70
ASP A  73
TYR A 114
 None
 1.36A 1kf6M-1wiwA:
0.0
1kf6N-1wiwA:
undetectable		 1kf6M-1wiwA:
20.49
1kf6N-1wiwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A  97
GLY A  71
ASP A  73
TYR A 114
 None
 0.95A 1kf6M-1wiwA:
0.0
1kf6N-1wiwA:
undetectable		 1kf6M-1wiwA:
20.49
1kf6N-1wiwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		3 / 3 THR A 122
LEU A 119
VAL A 127
 None
 0.66A 1mz9E-1wiwA:
undetectable		 1mz9E-1wiwA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 255
GLU A 176
LEU A 171
PHE A 172
 None
 1.11A 1s8fB-1wiwA:
undetectable		 1s8fB-1wiwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 255
LEU A 171
ARG A 173
PHE A 172
 None
 1.11A 1s8fB-1wiwA:
undetectable		 1s8fB-1wiwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A  90
GLY A  63
ALA A  89
HIS A  39
 None
 1.00A 1wmqA-1wiwA:
undetectable		 1wmqA-1wiwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A  90
GLY A  63
ALA A  89
HIS A  39
 None
 0.98A 1wrqA-1wiwA:
undetectable		 1wrqA-1wiwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A  43
PRO A 111
ALA A 110
ILE A 104
 None
 0.89A 2aofA-1wiwA:
undetectable		 2aofA-1wiwA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 166
LEU A 216
GLU A 207
LEU A 206
ARG A 237
 None
 1.24A 2bxfA-1wiwA:
undetectable		 2bxfA-1wiwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  68
LEU A 115
LEU A 118
LEU A  56
ALA A  41
 None
 0.94A 2egvB-1wiwA:
undetectable		 2egvB-1wiwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A  24
ARG A 185
LEU A 182
ALA A 110
 None
 1.08A 3b9mA-1wiwA:
undetectable		 3b9mA-1wiwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 9 PRO A 277
ALA A 266
THR A 193
PHE A 167
PRO A 165
 None
 1.29A 3qelD-1wiwA:
0.4		 3qelD-1wiwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 9 THR A 159
LEU A 160
ALA A 242
LEU A 221
THR A 265
 None
 1.32A 4ltwA-1wiwA:
0.0		 4ltwA-1wiwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  17
THR A  15
THR A 265
MET A 262
 None
 1.14A 4mbsA-1wiwA:
undetectable		 4mbsA-1wiwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR A 273
PRO A 277
ALA A 266
THR A 193
PRO A 165
 None
 1.26A 5ewjC-1wiwA:
2.5
5ewjD-1wiwA:
undetectable		 5ewjC-1wiwA:
21.00
5ewjD-1wiwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A 177
PRO A 165
THR A 193
THR A 181
 None
 1.26A 5h5fA-1wiwA:
undetectable		 5h5fA-1wiwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 230
PRO A 194
PHE A 202
GLY A 205
GLU A 200
 None
 1.30A 5hfjC-1wiwA:
undetectable		 5hfjC-1wiwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 230
PRO A 194
PHE A 202
GLY A 205
GLU A 200
 None
 1.30A 5hfjG-1wiwA:
undetectable		 5hfjG-1wiwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A  42
ALA A  51
LEU A  52
LEU A 118
 None
 0.78A 5vkqA-1wiwA:
undetectable
5vkqD-1wiwA:
undetectable		 5vkqA-1wiwA:
11.52
5vkqD-1wiwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 118
LEU A  42
ALA A  51
LEU A  52
 None
 0.80A 5vkqA-1wiwA:
undetectable
5vkqB-1wiwA:
undetectable		 5vkqA-1wiwA:
11.52
5vkqB-1wiwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 118
LEU A  42
ALA A  51
LEU A  52
 None
 0.78A 5vkqB-1wiwA:
undetectable
5vkqC-1wiwA:
undetectable		 5vkqB-1wiwA:
11.52
5vkqC-1wiwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 118
LEU A  42
ALA A  51
LEU A  52
 None
 0.83A 5vkqC-1wiwA:
undetectable
5vkqD-1wiwA:
undetectable		 5vkqC-1wiwA:
11.52
5vkqD-1wiwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A  35
HIS A  39
PHE A  66
 None
 1.07A 6esmA-1wiwA:
undetectable		 6esmA-1wiwA:
12.68