SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_A_PM6A302_1 (THIOPURINE S-METHYLTRANSFERASE)	1wk2	HYPOTHETICAL PROTEIN (Thermus thermophilus)	4 / 6	HIS A 34 THR A 32 LEU A 38 LEU A 8	None	0.82A	3bgdA-1wk2A: undetectable	3bgdA-1wk2A: 23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B302_1 (THIOPURINE S-METHYLTRANSFERASE)	1wk2	HYPOTHETICAL PROTEIN (Thermus thermophilus)	4 / 7	HIS A 34 THR A 32 LEU A 38 LEU A 8	None	0.85A	3bgdB-1wk2A: undetectable	3bgdB-1wk2A: 23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_A_SAMA301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	1wk2	HYPOTHETICAL PROTEIN (Thermus thermophilus)	5 / 12	GLY A 48 GLY A 39 LEU A 102 ALA A 95 GLU A 99	None	1.06A	4lg1A-1wk2A: undetectable	4lg1A-1wk2A: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_B_SAMB301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	1wk2	HYPOTHETICAL PROTEIN (Thermus thermophilus)	5 / 12	GLY A 48 GLY A 39 LEU A 102 ALA A 95 GLU A 99	None	1.05A	4lg1B-1wk2A: undetectable	4lg1B-1wk2A: 21.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BGD_A_PM6A302_1","THIOPURINE S-METHYLTRANSFERASE","1wk2","HYPOTHETICAL PROTEIN","Thermus thermophilus",4,"HIS A  34;THR A  32;LEU A  38;LEU A   8","None","0.82A","3bgdA-1wk2A:undetectable","3bgdA-1wk2A:23.67"],["3BGD_B_PM6B302_1","THIOPURINE S-METHYLTRANSFERASE","1wk2","HYPOTHETICAL PROTEIN","Thermus thermophilus",4,"HIS A  34;THR A  32;LEU A  38;LEU A   8","None","0.85A","3bgdB-1wk2A:undetectable","3bgdB-1wk2A:23.67"],["4LG1_A_SAMA301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","1wk2","HYPOTHETICAL PROTEIN","Thermus thermophilus",5,"GLY A  48;GLY A  39;LEU A 102;ALA A  95;GLU A  99","None","1.06A","4lg1A-1wk2A:undetectable","4lg1A-1wk2A:21.68"],["4LG1_B_SAMB301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","1wk2","HYPOTHETICAL PROTEIN","Thermus thermophilus",5,"GLY A  48;GLY A  39;LEU A 102;ALA A  95;GLU A  99","None","1.05A","4lg1B-1wk2A:undetectable","4lg1B-1wk2A:21.68"]]