SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 5 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.20A 1dz6A-1wk4A:
0.0		 1dz6A-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 ALA A  75
VAL A  17
LEU A  18
ALA A  15
ALA A  44
 None
 1.08A 1jinA-1wk4A:
undetectable		 1jinA-1wk4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 8 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.15A 1o76B-1wk4A:
undetectable		 1o76B-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 5 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.20A 1t88B-1wk4A:
0.0		 1t88B-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 8 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.19A 1uyuA-1wk4A:
undetectable		 1uyuA-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 8 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.15A 1uyuB-1wk4A:
0.0		 1uyuB-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 5 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.22A 2m56A-1wk4A:
undetectable		 2m56A-1wk4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 5 GLY A 138
ARG A 137
TYR A 165
TYR A 140
 None
 1.44A 2wb9A-1wk4A:
0.0		 2wb9A-1wk4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1wk4 TTK003001606
(Thermus
thermophilus) 		3 / 3 GLU A  69
ASP A  20
TYR A  40
 None
 0.87A 2yvlB-1wk4A:
2.8		 2yvlB-1wk4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 12 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.23A 3ag4A-1wk4A:
undetectable
3ag4B-1wk4A:
0.0
3ag4T-1wk4A:
undetectable		 3ag4A-1wk4A:
14.65
3ag4B-1wk4A:
21.15
3ag4T-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.15A 3wg7A-1wk4A:
undetectable
3wg7B-1wk4A:
0.0
3wg7T-1wk4A:
0.0		 3wg7A-1wk4A:
14.65
3wg7B-1wk4A:
21.15
3wg7T-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.14A 3x2qA-1wk4A:
undetectable
3x2qB-1wk4A:
0.0
3x2qT-1wk4A:
0.0		 3x2qA-1wk4A:
14.65
3x2qB-1wk4A:
21.15
3x2qT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 5 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.19A 4l49A-1wk4A:
undetectable		 4l49A-1wk4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 8 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.13A 4l4eA-1wk4A:
0.0		 4l4eA-1wk4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 8 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.14A 4l4fA-1wk4A:
undetectable		 4l4fA-1wk4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.14A 5b1aA-1wk4A:
undetectable
5b1aB-1wk4A:
0.0
5b1aT-1wk4A:
0.0		 5b1aA-1wk4A:
14.65
5b1aB-1wk4A:
21.15
5b1aT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.12A 5b1bA-1wk4A:
undetectable
5b1bB-1wk4A:
0.0
5b1bT-1wk4A:
0.0		 5b1bA-1wk4A:
14.65
5b1bB-1wk4A:
21.15
5b1bT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.12A 5b3sA-1wk4A:
undetectable
5b3sB-1wk4A:
0.0
5b3sT-1wk4A:
0.0		 5b3sA-1wk4A:
14.65
5b3sB-1wk4A:
21.15
5b3sT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1wk4 TTK003001606
(Thermus
thermophilus) 		3 / 3 LYS A 135
LEU A 143
ILE A  94
 None
None
MES  A 201 (-4.2A)
 0.73A 5kc0A-1wk4A:
undetectable		 5kc0A-1wk4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1wk4 TTK003001606
(Thermus
thermophilus) 		4 / 6 PHE A 167
LEU A 117
ARG A 124
GLY A 123
 None
 1.14A 5o4yF-1wk4A:
undetectable		 5o4yF-1wk4A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 PHE A 139
GLY A 136
GLN A 101
THR A  21
THR A  25
 MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
None
None
None
 1.23A 5x1fG-1wk4A:
0.0
5x1fN-1wk4A:
undetectable
5x1fO-1wk4A:
0.0		 5x1fG-1wk4A:
18.86
5x1fN-1wk4A:
14.65
5x1fO-1wk4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.16A 5xdqA-1wk4A:
undetectable
5xdqB-1wk4A:
0.0
5xdqT-1wk4A:
0.0		 5xdqA-1wk4A:
14.65
5xdqB-1wk4A:
21.15
5xdqT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.15A 5xdxA-1wk4A:
undetectable
5xdxB-1wk4A:
0.0
5xdxT-1wk4A:
0.0		 5xdxA-1wk4A:
14.65
5xdxB-1wk4A:
21.15
5xdxT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.13A 5z84A-1wk4A:
0.3
5z84B-1wk4A:
0.0
5z84T-1wk4A:
0.0		 5z84A-1wk4A:
14.65
5z84B-1wk4A:
21.15
5z84T-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.13A 5z86A-1wk4A:
undetectable
5z86B-1wk4A:
0.0
5z86T-1wk4A:
0.0		 5z86A-1wk4A:
14.65
5z86B-1wk4A:
21.15
5z86T-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.16A 5zcoA-1wk4A:
undetectable
5zcoB-1wk4A:
0.0
5zcoT-1wk4A:
0.0		 5zcoA-1wk4A:
14.65
5zcoB-1wk4A:
21.15
5zcoT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.14A 5zcpA-1wk4A:
0.7
5zcpB-1wk4A:
0.0
5zcpT-1wk4A:
0.0		 5zcpA-1wk4A:
14.65
5zcpB-1wk4A:
21.15
5zcpT-1wk4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1wk4 TTK003001606
(Thermus
thermophilus) 		5 / 11 GLN A 101
THR A  21
THR A  25
PHE A 139
GLY A 136
 None
None
None
MES  A 201 ( 4.3A)
MES  A 201 (-3.3A)
 1.11A 5zcqA-1wk4A:
undetectable
5zcqB-1wk4A:
0.0
5zcqT-1wk4A:
0.0		 5zcqA-1wk4A:
14.65
5zcqB-1wk4A:
21.15
5zcqT-1wk4A:
18.86