SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 215
LEU A 197
THR A 199
LEU A 200
 TSB  A 999 (-3.8A)
None
None
None
 0.87A 1jgsA-1wk9A:
undetectable		 1jgsA-1wk9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ASP A 223
LEU A 200
TYR A 202
LEU A 309
PRO A 306
 None
 1.47A 1p33D-1wk9A:
undetectable		 1p33D-1wk9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 9 ILE A 210
ALA A 256
VAL A 228
LYS A 262
 None
 0.98A 2vufB-1wk9A:
undetectable		 2vufB-1wk9A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
HIS A 275
LEU A 288
ALA A 227
THR A 214
 TSB  A 999 (-4.1A)
None
None
None
TSB  A 999 (-4.4A)
 0.96A 3dfrA-1wk9A:
undetectable		 3dfrA-1wk9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 LEU A 331
PHE A 325
PRO A 217
ALA A 321
 None
 1.47A 3vm4A-1wk9A:
0.0		 3vm4A-1wk9A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 298
PHE A 315
ARG A 318
GLU A 218
LEU A 296
 None
 1.29A 4azsA-1wk9A:
undetectable		 4azsA-1wk9A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.19A 4oltA-1wk9A:
undetectable		 4oltA-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.18A 4oltB-1wk9A:
undetectable		 4oltB-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.18A 4qwpA-1wk9A:
undetectable		 4qwpA-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.14A 4qwpB-1wk9A:
0.0		 4qwpB-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 THR A 219
PRO A 217
TYR A 198
GLY A 195
 TSB  A 999 (-3.8A)
None
None
None
 0.77A 5nzyA-1wk9A:
undetectable		 5nzyA-1wk9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 318
ARG A 319
ALA A 321
PRO A 217
 None
 1.26A 5odqA-1wk9A:
undetectable		 5odqA-1wk9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 VAL A 228
ASP A 257
PRO A 258
ALA A 227
 None
 1.10A 5otrA-1wk9A:
undetectable		 5otrA-1wk9A:
18.66