SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IT4_A_PPFA500_1 (CARBONIC ANHYDRASE 1)	1wkc	HB8 TT1367 PROTEIN (Thermus thermophilus)	4 / 8	HIS A 162 ALA A 164 VAL A 169 LEU A 34	None	0.83A	2it4A-1wkcA: undetectable	2it4A-1wkcA: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O14_A_NIOA300_1 (ANTI-ECFSIGMA FACTOR, CHRR)	1wkc	HB8 TT1367 PROTEIN (Thermus thermophilus)	4 / 7	ALA A 137 VAL A 169 VAL A 139 LEU A 105	None	0.80A	3o14A-1wkcA: undetectable	3o14A-1wkcA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIM_A_CELA711_1 (LACTOTRANSFERRIN)	1wkc	HB8 TT1367 PROTEIN (Thermus thermophilus)	5 / 9	GLY A 140 VAL A 142 PRO A 109 TYR A 127 GLY A 121	None None None SO4 A 200 (-4.9A) SO4 A 201 ( 3.1A)	1.10A	4fimA-1wkcA: undetectable	4fimA-1wkcA: 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GRK_A_KTRA713_1 (LACTOTRANSFERRIN)	1wkc	HB8 TT1367 PROTEIN (Thermus thermophilus)	4 / 5	GLY A 140 VAL A 142 PRO A 109 TYR A 127	None None None SO4 A 200 (-4.9A)	1.04A	4grkA-1wkcA: undetectable	4grkA-1wkcA: 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_B_MMSB514_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	1wkc	HB8 TT1367 PROTEIN (Thermus thermophilus)	4 / 8	HIS A 46 SER A 23 ASN A 53 LEU A 19	None	1.03A	5m8rB-1wkcA: undetectable	5m8rB-1wkcA: 17.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2IT4_A_PPFA500_1","CARBONIC ANHYDRASE 1","1wkc","HB8 TT1367 PROTEIN","Thermus thermophilus",4,"HIS A 162;ALA A 164;VAL A 169;LEU A  34","None","0.83A","2it4A-1wkcA:undetectable","2it4A-1wkcA:17.83"],["3O14_A_NIOA300_1","ANTI-ECFSIGMA FACTOR, CHRR","1wkc","HB8 TT1367 PROTEIN","Thermus thermophilus",4,"ALA A 137;VAL A 169;VAL A 139;LEU A 105","None","0.80A","3o14A-1wkcA:undetectable","3o14A-1wkcA:23.08"],["4FIM_A_CELA711_1","LACTOTRANSFERRIN","1wkc","HB8 TT1367 PROTEIN","Thermus thermophilus",5,"GLY A 140;VAL A 142;PRO A 109;TYR A 127;GLY A 121","None;None;None;SO4 A 200 (-4.9A);SO4 A 201 ( 3.1A)","1.10A","4fimA-1wkcA:undetectable","4fimA-1wkcA:20.99"],["4GRK_A_KTRA713_1","LACTOTRANSFERRIN","1wkc","HB8 TT1367 PROTEIN","Thermus thermophilus",4,"GLY A 140;VAL A 142;PRO A 109;TYR A 127","None;None;None;SO4 A 200 (-4.9A)","1.04A","4grkA-1wkcA:undetectable","4grkA-1wkcA:20.99"],["5M8R_B_MMSB514_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","1wkc","HB8 TT1367 PROTEIN","Thermus thermophilus",4,"HIS A  46;SER A  23;ASN A  53;LEU A  19","None","1.03A","5m8rB-1wkcA:undetectable","5m8rB-1wkcA:17.50"]]