SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 PHE A  50
ALA A 185
HIS A 153
HIS A 161
ASP A  82
 MET  A1298 (-3.8A)
MN  A 296 ( 3.9A)
MN  A 296 ( 3.3A)
MET  A1298 (-4.0A)
MN  A 297 ( 1.7A)
 1.23A 1a4lA-1wkmA:
undetectable		 1a4lA-1wkmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 PHE A  50
ALA A 185
HIS A 153
HIS A 161
ASP A  82
 MET  A1298 (-3.8A)
MN  A 296 ( 3.9A)
MN  A 296 ( 3.3A)
MET  A1298 (-4.0A)
MN  A 297 ( 1.7A)
 1.24A 1a4lB-1wkmA:
undetectable		 1a4lB-1wkmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 PHE A  50
ALA A 185
HIS A 153
HIS A 161
ASP A  82
 MET  A1298 (-3.8A)
MN  A 296 ( 3.9A)
MN  A 296 ( 3.3A)
MET  A1298 (-4.0A)
MN  A 297 ( 1.7A)
 1.21A 1a4lC-1wkmA:
undetectable		 1a4lC-1wkmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 PHE A  50
ALA A 185
HIS A 153
HIS A 161
ASP A  82
 MET  A1298 (-3.8A)
MN  A 296 ( 3.9A)
MN  A 296 ( 3.3A)
MET  A1298 (-4.0A)
MN  A 297 ( 1.7A)
 1.30A 1a4lD-1wkmA:
undetectable		 1a4lD-1wkmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 TYR A 263
TYR A 265
GLU A 187
HIS A 153
GLY A 152
 None
MET  A1298 ( 4.7A)
MN  A 296 ( 2.6A)
MN  A 296 ( 3.3A)
None
 1.31A 1aclA-1wkmA:
undetectable		 1aclA-1wkmA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.65A 1c9sI-1wkmA:
undetectable
1c9sJ-1wkmA:
undetectable		 1c9sI-1wkmA:
15.29
1c9sJ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.67A 1c9sU-1wkmA:
undetectable
1c9sV-1wkmA:
undetectable		 1c9sU-1wkmA:
15.29
1c9sV-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.65A 1gtnA-1wkmA:
undetectable
1gtnK-1wkmA:
undetectable		 1gtnA-1wkmA:
15.29
1gtnK-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.62A 1gtnA-1wkmA:
undetectable
1gtnB-1wkmA:
undetectable		 1gtnA-1wkmA:
15.29
1gtnB-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.64A 1gtnE-1wkmA:
undetectable
1gtnF-1wkmA:
undetectable		 1gtnE-1wkmA:
15.29
1gtnF-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.69A 1gtnI-1wkmA:
undetectable
1gtnJ-1wkmA:
undetectable		 1gtnI-1wkmA:
15.29
1gtnJ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.69A 1gtnP-1wkmA:
undetectable
1gtnQ-1wkmA:
undetectable		 1gtnP-1wkmA:
15.29
1gtnQ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  82
GLU A 187
HIS A 153
TYR A 265
PRO A  51
 MN  A 297 ( 1.7A)
MN  A 296 ( 2.6A)
MN  A 296 ( 3.3A)
MET  A1298 ( 4.7A)
None
 1.14A 1ituA-1wkmA:
undetectable		 1ituA-1wkmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  82
HIS A 153
HIS A 161
TYR A 265
PRO A  51
 MN  A 297 ( 1.7A)
MN  A 296 ( 3.3A)
MET  A1298 (-4.0A)
MET  A1298 ( 4.7A)
None
 1.43A 1ituA-1wkmA:
undetectable		 1ituA-1wkmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  82
GLU A 187
HIS A 153
TYR A 265
PRO A  51
 MN  A 297 ( 1.7A)
MN  A 296 ( 2.6A)
MN  A 296 ( 3.3A)
MET  A1298 ( 4.7A)
None
 1.18A 1ituB-1wkmA:
undetectable		 1ituB-1wkmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  82
HIS A 153
HIS A 161
TYR A 265
PRO A  51
 MN  A 297 ( 1.7A)
MN  A 296 ( 3.3A)
MET  A1298 (-4.0A)
MET  A1298 ( 4.7A)
None
 1.42A 1ituB-1wkmA:
undetectable		 1ituB-1wkmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 181
ASP A 182
ILE A 283
PHE A 184
ALA A 118
 None
 1.10A 1oltA-1wkmA:
undetectable		 1oltA-1wkmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.66A 1utdB-1wkmA:
undetectable
1utdC-1wkmA:
undetectable		 1utdB-1wkmA:
15.29
1utdC-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.65A 1utdF-1wkmA:
undetectable
1utdG-1wkmA:
undetectable		 1utdF-1wkmA:
15.29
1utdG-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.65A 1utdI-1wkmA:
undetectable
1utdJ-1wkmA:
undetectable		 1utdI-1wkmA:
15.29
1utdJ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.63A 1utdJ-1wkmA:
undetectable
1utdK-1wkmA:
undetectable		 1utdJ-1wkmA:
15.29
1utdK-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 TYR A 265
GLU A 187
HIS A 153
GLY A 152
 MET  A1298 ( 4.7A)
MN  A 296 ( 2.6A)
MN  A 296 ( 3.3A)
None
 0.83A 2ha4A-1wkmA:
undetectable		 2ha4A-1wkmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 265
GLU A 187
HIS A 153
GLY A 152
 MET  A1298 ( 4.7A)
MN  A 296 ( 2.6A)
MN  A 296 ( 3.3A)
None
 0.81A 2ha4B-1wkmA:
undetectable		 2ha4B-1wkmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 LEU A  79
ILE A  81
LEU A  54
LEU A  73
 None
 0.70A 2xfhA-1wkmA:
undetectable		 2xfhA-1wkmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 GLU A 136
ALA A 111
PRO A 146
ALA A 190
 None
 1.12A 2zgwB-1wkmA:
undetectable		 2zgwB-1wkmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 160
VAL A  85
GLY A  84
THR A 282
ILE A 155
 None
 0.96A 3bf1A-1wkmA:
undetectable
3bf1B-1wkmA:
undetectable		 3bf1A-1wkmA:
22.26
3bf1B-1wkmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 LEU A  54
SER A  55
ILE A  37
ALA A  95
ALA A  20
 None
None
None
MN  A 297 ( 4.8A)
None
 1.08A 3mdtB-1wkmA:
undetectable		 3mdtB-1wkmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 ALA A  49
PHE A  50
ALA A  13
THR A 294
 None
MET  A1298 (-3.8A)
None
None
 0.83A 3t3sD-1wkmA:
undetectable		 3t3sD-1wkmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 4 LEU A   6
ALA A  92
ILE A  91
LYS A   1
 None
 1.42A 4eixA-1wkmA:
undetectable		 4eixA-1wkmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 6 VAL A 100
ALA A  24
LEU A  54
THR A  71
LEU A  30
 None
 1.39A 4o0uA-1wkmA:
undetectable		 4o0uA-1wkmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 VAL A  83
ALA A  92
PHE A  50
 None
None
MET  A1298 (-3.8A)
 0.89A 4olbA-1wkmA:
undetectable		 4olbA-1wkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 9 ALA A  49
PHE A  50
ILE A  81
VAL A  96
THR A 294
 None
MET  A1298 (-3.8A)
None
None
None
 1.26A 4r20B-1wkmA:
undetectable		 4r20B-1wkmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 VAL A  83
ALA A  92
PHE A  50
 None
None
MET  A1298 (-3.8A)
 0.89A 4w5nA-1wkmA:
undetectable		 4w5nA-1wkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 VAL A  83
ALA A  92
PHE A  50
 None
None
MET  A1298 (-3.8A)
 0.90A 4z4iA-1wkmA:
undetectable		 4z4iA-1wkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 HIS A 153
ILE A 164
ILE A 166
TYR A 176
 MN  A 296 ( 3.3A)
None
None
None
 1.03A 5dnuA-1wkmA:
undetectable		 5dnuA-1wkmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 HIS A 153
ILE A 164
ILE A 166
TYR A 176
 MN  A 296 ( 3.3A)
None
None
None
 1.10A 5dnvA-1wkmA:
undetectable		 5dnvA-1wkmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 9 TYR A 263
TYR A 265
GLU A 187
HIS A 153
GLY A 152
 None
MET  A1298 ( 4.7A)
MN  A 296 ( 2.6A)
MN  A 296 ( 3.3A)
None
 1.21A 5e4jA-1wkmA:
0.4		 5e4jA-1wkmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 VAL A  83
ALA A  92
PHE A  50
 None
None
MET  A1298 (-3.8A)
 0.88A 5js1A-1wkmA:
undetectable		 5js1A-1wkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 GLU A 280
ALA A 185
PHE A 189
ASN A  53
 MN  A 297 (-2.5A)
MN  A 296 ( 3.9A)
None
MET  A1298 (-3.0A)
 0.83A 5mvsA-1wkmA:
undetectable		 5mvsA-1wkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 280
ALA A 185
PHE A 189
ASN A  53
 MN  A 297 (-2.5A)
MN  A 296 ( 3.9A)
None
MET  A1298 (-3.0A)
 0.84A 5mvsB-1wkmA:
undetectable		 5mvsB-1wkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 GLY A 152
HIS A 153
ASP A  93
HIS A  62
 None
MN  A 296 ( 3.3A)
MN  A 297 (-2.3A)
MET  A1298 (-3.8A)
 0.83A 5nnwD-1wkmA:
undetectable		 5nnwD-1wkmA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 110
PHE A  50
ALA A  49
ALA A  92
THR A 294
 None
MET  A1298 (-3.8A)
None
None
None
 1.25A 5tl8A-1wkmA:
undetectable		 5tl8A-1wkmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 110
PHE A  50
ALA A  49
ALA A  92
THR A 294
 None
MET  A1298 (-3.8A)
None
None
None
 1.21A 6aycA-1wkmA:
undetectable		 6aycA-1wkmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1wkm METHIONINE
AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 LYS A  74
VAL A  72
ASP A  77
 None
 0.70A 6fgdA-1wkmA:
undetectable		 6fgdA-1wkmA:
23.95