SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 LEU A  12
ASN A  42
VAL A 124
ALA A 163
 None
 0.96A 2cizA-1wkoA:
undetectable		 2cizA-1wkoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 122
VAL A  71
THR A 148
 None
 0.79A 2nmzA-1wkoA:
undetectable		 2nmzA-1wkoA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 122
VAL A  71
THR A 148
 None
 0.84A 2nnkA-1wkoA:
undetectable		 2nnkA-1wkoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ARG A 143
PHE A 146
ILE A 140
PHE A 151
 None
 1.15A 2qb4A-1wkoA:
undetectable		 2qb4A-1wkoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ARG A 143
PHE A 146
ILE A 140
PHE A 151
 None
 1.18A 2qeiA-1wkoA:
undetectable		 2qeiA-1wkoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ALA A 162
LEU A  70
PHE A 128
ILE A  73
THR A  29
 None
 1.09A 3hj3A-1wkoA:
undetectable		 3hj3A-1wkoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 122
VAL A  71
THR A 148
 None
 0.83A 3k4vA-1wkoA:
undetectable		 3k4vA-1wkoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 122
VAL A  71
THR A 148
 None
 0.74A 3ndtA-1wkoA:
undetectable		 3ndtA-1wkoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 122
VAL A  71
THR A 148
 None
 0.84A 3pwrA-1wkoA:
undetectable		 3pwrA-1wkoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 122
VAL A  71
THR A 148
 None
 0.84A 3tl9A-1wkoA:
undetectable		 3tl9A-1wkoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 PHE A  47
LEU A  46
PRO A  48
SER A  49
 None
 1.33A 3vlnA-1wkoA:
undetectable		 3vlnA-1wkoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		5 / 9 ASP A  23
VAL A 126
ALA A 163
GLY A 158
PHE A 128
 None
 1.14A 4mmeB-1wkoA:
undetectable		 4mmeB-1wkoA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 VAL A  51
PHE A 123
HIS A 121
GLU A  45
 None
 1.44A 5ad9A-1wkoA:
undetectable
5ad9B-1wkoA:
undetectable		 5ad9A-1wkoA:
17.61
5ad9B-1wkoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1wko TERMINAL FLOWER 1
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ALA A 162
LEU A  70
PHE A 128
ILE A  73
THR A  29
 None
 1.12A 5z6fA-1wkoA:
undetectable		 5z6fA-1wkoA:
24.10