SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 THR A  27
LEU A  28
VAL A 160
 SO4  A1001 (-3.6A)
None
None
 0.62A 1mz9E-1wkpA:
undetectable		 1mz9E-1wkpA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR A 151
LEU A  89
PRO A 136
ILE A 150
PHE A 142
 None
 1.41A 1xoqA-1wkpA:
undetectable		 1xoqA-1wkpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 THR A 144
LEU A  67
VAL A  68
VAL A  14
VAL A  18
 None
 1.28A 2a1nA-1wkpA:
undetectable		 2a1nA-1wkpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		5 / 8 PHE A  22
LEU A  28
VAL A  14
LEU A   9
VAL A  18
 None
 1.25A 2zujA-1wkpA:
undetectable		 2zujA-1wkpA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR A 151
LEU A  89
PRO A 136
ILE A 150
PHE A 142
 None
 1.37A 3g4lB-1wkpA:
undetectable		 3g4lB-1wkpA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 TYR A  65
THR A  66
PHE A 125
LEU A 128
 None
 1.22A 3qelC-1wkpA:
undetectable		 3qelC-1wkpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ILE A  56
LEU A 124
ARG A  53
THR A  31
 None
 1.18A 3wg7A-1wkpA:
undetectable
3wg7J-1wkpA:
undetectable		 3wg7A-1wkpA:
17.54
3wg7J-1wkpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 LEU A 124
PHE A  22
ILE A 123
 None
 0.74A 5dzk1-1wkpA:
undetectable
5dzkF-1wkpA:
undetectable
5dzkM-1wkpA:
undetectable		 5dzk1-1wkpA:
4.35
5dzkF-1wkpA:
21.27
5dzkM-1wkpA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1wkp FLOWERING LOCUS T
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A  22
ILE A 123
LEU A  86
LEU A 153
TYR A 151
 None
 1.45A 5fctB-1wkpA:
0.0		 5fctB-1wkpA:
21.80