SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 8 ILE A  84
LEU A 116
GLU A 108
ALA A 107
VAL A  82
 None
 1.18A 1a29A-1wkyA:
undetectable		 1a29A-1wkyA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 6 TYR A 225
GLY A 255
GLY A 252
SER A 283
 None
 0.99A 1eswA-1wkyA:
9.3		 1eswA-1wkyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 GLY A 467
LEU A 424
LEU A 450
VAL A 408
PHE A 470
 None
 1.13A 1gseA-1wkyA:
undetectable		 1gseA-1wkyA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 ALA A 175
ILE A 190
VAL A 209
ILE A 153
ILE A 155
 None
 0.79A 1hshA-1wkyA:
undetectable		 1hshA-1wkyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 9 ALA A 175
ILE A 190
VAL A 209
ILE A 153
ILE A 155
 None
 0.83A 1hshB-1wkyA:
undetectable		 1hshB-1wkyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 VAL A 151
LEU A 144
SER A 142
THR A 150
GLU A 108
 None
 1.31A 1kw0A-1wkyA:
undetectable		 1kw0A-1wkyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		3 / 3 ASP A 120
THR A 122
GLU A 253
 None
None
NA  A 505 (-2.8A)
 0.82A 1pj7A-1wkyA:
undetectable		 1pj7A-1wkyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 8 THR A  81
LEU A 280
VAL A 250
GLY A 278
 None
 0.89A 2a1oA-1wkyA:
undetectable		 2a1oA-1wkyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 LEU A 103
SER A  87
LEU A  86
VAL A 118
ASP A 120
 None
 1.07A 2c12C-1wkyA:
0.0		 2c12C-1wkyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 7 GLY A 431
THR A 433
TYR A 435
ASN A 310
 None
 0.74A 2g70A-1wkyA:
undetectable		 2g70A-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 7 GLY A 431
THR A 433
TYR A 435
ASN A 310
 None
 0.71A 2g70B-1wkyA:
undetectable		 2g70B-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 6 TYR A  44
GLY A  40
TYR A  37
ASP A 246
 None
 1.29A 2g72A-1wkyA:
undetectable		 2g72A-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		3 / 3 LEU A 188
ASN A 186
ARG A 180
 None
 0.77A 2qhfA-1wkyA:
undetectable		 2qhfA-1wkyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		3 / 3 GLN A 197
THR A 122
TRP A 282
 None
 1.12A 2rctA-1wkyA:
undetectable		 2rctA-1wkyA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		6 / 12 ASN A 157
GLU A 158
HIS A 223
TYR A 225
GLU A 253
TRP A 282
 NA  A 505 ( 4.7A)
NA  A 505 (-2.9A)
None
None
NA  A 505 (-2.8A)
None
 0.68A 2v3dA-1wkyA:
15.9		 2v3dA-1wkyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 11 ASN A 157
GLU A 158
TYR A 225
GLU A 253
TRP A 282
 NA  A 505 ( 4.7A)
NA  A 505 (-2.9A)
None
NA  A 505 (-2.8A)
None
 0.77A 2v3dB-1wkyA:
10.7		 2v3dB-1wkyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 8 THR A 407
GLN A 405
ARG A 403
ILE A 488
 None
 1.10A 2xytE-1wkyA:
undetectable		 2xytE-1wkyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 8 THR A 407
GLN A 405
ARG A 403
ILE A 488
 None
 0.98A 2xytH-1wkyA:
undetectable		 2xytH-1wkyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 7 TYR A 389
SER A 357
GLN A 471
ILE A 482
 None
 1.11A 2xz5A-1wkyA:
0.0
2xz5B-1wkyA:
0.0		 2xz5A-1wkyA:
19.74
2xz5B-1wkyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 8 GLN A 234
GLY A 230
PRO A 199
GLY A 194
 None
 0.83A 2y6rB-1wkyA:
undetectable		 2y6rB-1wkyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 ASN A 486
ILE A 466
THR A 428
VAL A 457
LEU A 454
 None
 1.31A 3a51B-1wkyA:
undetectable		 3a51B-1wkyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 ILE A 466
GLY A 467
VAL A 426
LEU A 390
VAL A 487
 None
 0.91A 3fpjA-1wkyA:
undetectable		 3fpjA-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		3 / 3 TYR A 124
ASP A  88
ASP A  95
 None
 0.79A 3ou6B-1wkyA:
undetectable		 3ou6B-1wkyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 9 ALA A 175
ILE A 190
VAL A 209
ILE A 153
ILE A 155
 None
 0.95A 3s43A-1wkyA:
undetectable		 3s43A-1wkyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 VAL A  38
ILE A 268
ILE A 239
VAL A 242
LEU A 243
 None
None
None
None
CL  A 501 (-4.3A)
 1.02A 3w67B-1wkyA:
undetectable		 3w67B-1wkyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 TRP A 282
ASP A  88
GLU A 117
ALA A  61
GLY A  90
 None
 1.03A 4hfpD-1wkyA:
undetectable		 4hfpD-1wkyA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 8 THR A  81
GLU A 117
ASN A 154
GLY A  55
 None
 0.89A 4r3aA-1wkyA:
undetectable		 4r3aA-1wkyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 11 TRP A 353
GLY A 352
ILE A 482
SER A 481
PRO A 362
 None
 1.31A 4rtrA-1wkyA:
undetectable		 4rtrA-1wkyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 5 ASP A  45
PHE A  51
PHE A  36
VAL A 113
 None
 1.20A 5a1rA-1wkyA:
undetectable		 5a1rA-1wkyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 8 TYR A 271
ILE A 268
GLY A 278
LEU A 243
 None
None
None
CL  A 501 (-4.3A)
 0.91A 5esfA-1wkyA:
undetectable		 5esfA-1wkyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 7 TYR A 271
ILE A 268
GLY A 278
LEU A 243
 None
None
None
CL  A 501 (-4.3A)
 0.92A 5esmA-1wkyA:
undetectable		 5esmA-1wkyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		4 / 5 PHE A 254
LEU A 319
GLY A 318
ILE A 268
 None
 1.01A 5ik1A-1wkyA:
0.0		 5ik1A-1wkyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 10 LEU A 296
GLY A  73
GLY A 302
LEU A 319
ALA A  79
 None
 0.97A 5l0zB-1wkyA:
3.4		 5l0zB-1wkyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 GLY A  59
VAL A 313
LEU A 305
GLY A  73
ILE A  74
 None
 1.09A 5vooB-1wkyA:
3.1		 5vooB-1wkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		5 / 12 GLY A  59
VAL A 313
LEU A 305
GLY A  73
ILE A  74
 None
 1.11A 5vooC-1wkyA:
5.7		 5vooC-1wkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1wky ENDO-BETA-1,4-MANNAN
ASE
(Bacillus
sp.
JAMB-602) 		3 / 3 LEU A 184
VAL A 134
ASP A 135
 None
 0.56A 5x23A-1wkyA:
undetectable		 5x23A-1wkyA:
22.64