SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 ILE A 199
GLY A 193
GLY A 168
SER A 167
LEU A 189
 None
 1.25A 1i9gA-1wl1A:
undetectable		 1i9gA-1wl1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 VAL A 135
ILE A 136
GLU A  71
LEU A  78
 None
 1.01A 1j96B-1wl1A:
undetectable		 1j96B-1wl1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 LEU A 180
LEU A 128
VAL A 135
ALA A  69
ALA A 116
 None
 1.23A 1n5xA-1wl1A:
undetectable		 1n5xA-1wl1A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 LEU A 180
LEU A 128
VAL A 135
ALA A  69
ALA A 116
 None
 1.22A 1n5xB-1wl1A:
2.2		 1n5xB-1wl1A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 11 LEU A 189
LEU A 192
LEU A 285
LEU A 175
ARG A  55
 None
 1.00A 2ceoA-1wl1A:
undetectable		 2ceoA-1wl1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		3 / 3 VAL A 112
VAL A  73
ASP A  85
 None
 0.74A 2fumD-1wl1A:
undetectable		 2fumD-1wl1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 271
VAL A 275
LYS A 276
ILE A 199
 None
 0.78A 2piwA-1wl1A:
2.3		 2piwA-1wl1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		6 / 9 LEU A  47
ILE A 196
GLY A 197
GLY A 168
SER A  48
LEU A 189
 None
 1.04A 2qmmA-1wl1A:
undetectable		 2qmmA-1wl1A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		6 / 11 LEU A  47
ILE A 196
GLY A 197
GLY A 168
SER A  48
LEU A 189
 None
 1.06A 2qmmA-1wl1A:
undetectable
2qmmB-1wl1A:
undetectable		 2qmmA-1wl1A:
23.73
2qmmB-1wl1A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 10 LEU A 189
LEU A 192
LEU A 285
LEU A 175
ARG A  55
 None
 0.92A 2riwA-1wl1A:
undetectable
2riwB-1wl1A:
undetectable		 2riwA-1wl1A:
22.53
2riwB-1wl1A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 8 ARG A  46
LEU A 175
GLY A 172
PHE A 171
 None
 0.92A 2tsrB-1wl1A:
undetectable		 2tsrB-1wl1A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 8 ALA A 174
LEU A 175
LEU A 192
VAL A 278
ILE A 279
 None
 1.12A 2uxpA-1wl1A:
1.6		 2uxpA-1wl1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A  24
ALA A  76
GLY A 109
PHE A  28
 None
 0.95A 2wq5A-1wl1A:
1.2		 2wq5A-1wl1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 180
LEU A 177
SER A  48
VAL A 194
 None
 0.93A 3d2tA-1wl1A:
undetectable		 3d2tA-1wl1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		3 / 3 VAL A 120
SER A  66
LEU A 128
 None
 0.74A 3n8xA-1wl1A:
undetectable		 3n8xA-1wl1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 ASP A  85
ASP A  81
ASP A  82
ARG A  91
 None
 1.35A 3naiA-1wl1A:
1.0		 3naiA-1wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		3 / 3 LYS A 224
SER A 167
GLN A 201
 None
 0.98A 3si7A-1wl1A:
undetectable		 3si7A-1wl1A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 VAL A 227
GLY A 226
TYR A 159
ASP A 205
 None
 1.42A 3w9tB-1wl1A:
undetectable		 3w9tB-1wl1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 VAL A 227
GLY A 226
TYR A 159
ASP A 205
 None
 1.42A 3w9tC-1wl1A:
undetectable		 3w9tC-1wl1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 VAL A 227
GLY A 226
TYR A 159
ASP A 205
 None
 1.42A 3w9tD-1wl1A:
undetectable		 3w9tD-1wl1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 VAL A 227
GLY A 226
TYR A 159
ASP A 205
 None
 1.42A 3w9tE-1wl1A:
undetectable		 3w9tE-1wl1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 VAL A 227
GLY A 226
TYR A 159
ASP A 205
 None
 1.42A 3w9tG-1wl1A:
undetectable		 3w9tG-1wl1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 6 ILE A 206
TRP A 251
ILE A 215
MET A 212
 None
 0.97A 3welA-1wl1A:
undetectable		 3welA-1wl1A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 PRO A  37
LEU A  79
GLN A  31
ILE A  96
TYR A 100
 None
 1.25A 4a79A-1wl1A:
undetectable		 4a79A-1wl1A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 PRO A  37
LEU A  79
GLN A  31
ILE A  96
TYR A 100
 None
 1.29A 4a79B-1wl1A:
undetectable		 4a79B-1wl1A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 11 ILE A  23
PHE A 132
ILE A 123
ALA A  69
ALA A  68
 None
 1.01A 4h1nA-1wl1A:
1.0		 4h1nA-1wl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 8 SER A  77
LEU A  78
ASP A  81
ARG A  90
LYS A 166
 None
 0.93A 4umjA-1wl1A:
21.5		 4umjA-1wl1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 8 SER A  77
LEU A  78
ASP A  85
ARG A  90
 None
 0.61A 4umjA-1wl1A:
21.5		 4umjA-1wl1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 9 SER A  77
LEU A  78
ASP A  81
ARG A  90
LYS A 166
 None
 0.97A 4umjB-1wl1A:
22.0		 4umjB-1wl1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 10 ILE A  20
PHE A  27
LEU A  72
LEU A 111
ALA A 108
 None
 1.06A 5y7pG-1wl1A:
undetectable		 5y7pG-1wl1A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 173
GLN A 176
LEU A 181
LEU A 128
 None
 0.97A 5yvnA-1wl1A:
2.2		 5yvnA-1wl1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		3 / 3 TYR A 159
PRO A 231
LEU A 232
 None
 0.84A 6beoA-1wl1A:
undetectable		 6beoA-1wl1A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 ARG A  19
LEU A 177
ALA A  69
LEU A 128
LEU A 181
 None
 1.02A 6f6iA-1wl1A:
undetectable
6f6iB-1wl1A:
undetectable		 6f6iA-1wl1A:
14.86
6f6iB-1wl1A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A  78
ASP A  81
ARG A  90
GLN A 201
 None
 1.00A 6g31D-1wl1A:
21.3		 6g31D-1wl1A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A  78
ASP A  81
ARG A  90
GLN A 201
 None
 0.94A 6g31J-1wl1A:
21.7		 6g31J-1wl1A:
13.29