SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 4 HIS A 159
LEU A 355
LEU A  61
LEU A 128
COA  A1001 (-4.5A)
CSO  A  92 ( 4.6A)
None
None
1.18A 1a4lD-1wl4A:
undetectable
1a4lD-1wl4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 8 ALA A 323
GLY A 385
ILE A 384
VAL A 327
COA  A1001 ( 3.8A)
CSO  A  92 ( 4.1A)
CSO  A  92 ( 4.7A)
None
0.79A 1d4sB-1wl4A:
undetectable
1d4sB-1wl4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 ALA A 381
VAL A 394
GLY A 378
ILE A 317
ILE A 301
None
0.85A 1fb7A-1wl4A:
undetectable
1fb7A-1wl4A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 4 LEU A 370
VAL A 394
CYH A 393
ALA A 304
None
1.29A 1mz9E-1wl4A:
undetectable
1mz9E-1wl4A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
3 / 3 GLY A  19
GLU A 220
ASP A 256
None
0.70A 2b25B-1wl4A:
undetectable
2b25B-1wl4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 10 ILE A  56
ALA A  98
ILE A  38
PRO A  84
GLU A  54
None
1.18A 2dm6A-1wl4A:
undetectable
2dm6B-1wl4A:
undetectable
2dm6A-1wl4A:
24.05
2dm6B-1wl4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 GLY A 118
GLY A 359
GLY A  95
ALA A  98
ASN A 321
None
CSO  A  92 ( 4.2A)
None
None
None
1.12A 2dpmA-1wl4A:
undetectable
2dpmA-1wl4A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 7 VAL A 364
THR A 365
THR A 369
ARG A 372
None
0.99A 2kotA-1wl4A:
undetectable
2kotA-1wl4A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 7 VAL A 207
ALA A  27
PRO A 204
THR A  16
None
0.99A 2q6oA-1wl4A:
undetectable
2q6oA-1wl4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 11 PHE A  57
ARG A  15
ALA A  24
MET A 119
LEU A  33
None
1.40A 2v0mA-1wl4A:
undetectable
2v0mA-1wl4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 9 PHE A  57
ARG A  15
ALA A  24
GLY A  34
LEU A  33
None
1.05A 2v0mB-1wl4A:
undetectable
2v0mB-1wl4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 9 PHE A  57
ARG A  15
LEU A 206
GLY A  34
LEU A  33
None
1.09A 2v0mB-1wl4A:
undetectable
2v0mB-1wl4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 GLY A 352
SER A 252
ALA A 348
ASN A 321
GLY A  95
None
COA  A1001 (-3.7A)
None
None
None
1.10A 2vmyB-1wl4A:
undetectable
2vmyB-1wl4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
3 / 3 SER A 123
GLY A  23
GLY A  19
None
0.43A 3bogA-1wl4A:
undetectable
3bogC-1wl4A:
undetectable
3bogA-1wl4A:
undetectable
3bogC-1wl4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 8 LEU A 355
GLY A 117
ALA A 259
THR A  16
ILE A  18
CSO  A  92 ( 4.6A)
None
None
None
None
1.24A 3jusB-1wl4A:
undetectable
3jusB-1wl4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 9 LEU A 355
GLY A 117
ALA A 259
THR A  16
ILE A  18
CSO  A  92 ( 4.6A)
None
None
None
None
1.24A 3jusB-1wl4A:
undetectable
3jusB-1wl4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
6 / 12 LEU A  42
GLY A  76
ASP A  32
VAL A  37
VAL A 115
ILE A  38
None
1.49A 3lzuB-1wl4A:
undetectable
3lzuB-1wl4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 ARG A  44
ALA A  45
HIS A 368
LEU A 277
ILE A  10
SO4  A3001 (-3.9A)
None
SO4  A3001 (-4.1A)
SO4  A3001 (-4.6A)
None
1.25A 3njzA-1wl4A:
0.0
3njzA-1wl4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 10 ARG A 279
ILE A 280
ALA A 278
LEU A 363
LEU A 367
None
1.16A 3o02A-1wl4A:
undetectable
3o02B-1wl4A:
undetectable
3o02A-1wl4A:
22.08
3o02B-1wl4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 9 ASP A 256
ILE A 214
PRO A 204
ILE A 202
ILE A  17
None
1.08A 3s56B-1wl4A:
undetectable
3s56B-1wl4A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 PHE A 238
HIS A 159
PHE A 324
SER A 252
LEU A 147
None
COA  A1001 (-4.5A)
COA  A1001 (-4.6A)
COA  A1001 (-3.7A)
None
1.43A 3u9fJ-1wl4A:
0.2
3u9fL-1wl4A:
0.3
3u9fJ-1wl4A:
22.99
3u9fL-1wl4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 CYH A 360
LEU A  96
ALA A  98
ALA A 260
ILE A  10
None
1.00A 3ut5D-1wl4A:
undetectable
3ut5D-1wl4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 8 GLY A 386
GLY A 385
MET A 293
GLY A 296
VAL A 286
None
CSO  A  92 ( 4.1A)
COA  A1001 (-4.5A)
None
None
1.11A 3v1nA-1wl4A:
undetectable
3v1nA-1wl4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 8 GLY A 386
MET A 293
GLY A 296
ILE A 390
VAL A 286
None
COA  A1001 (-4.5A)
None
None
None
1.25A 3v1nA-1wl4A:
undetectable
3v1nA-1wl4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 11 GLY A  58
ALA A 260
GLY A 117
VAL A  70
MET A 119
None
1.42A 4c5lA-1wl4A:
undetectable
4c5lA-1wl4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 9 GLY A  58
ALA A 260
GLY A 117
VAL A  70
MET A 119
None
1.44A 4c5lB-1wl4A:
undetectable
4c5lB-1wl4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 10 GLY A  58
ALA A 260
GLY A 117
VAL A  70
MET A 119
None
1.45A 4c5lC-1wl4A:
undetectable
4c5lC-1wl4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 10 GLY A  58
ALA A 260
GLY A 117
VAL A  70
MET A 119
None
1.46A 4c5lD-1wl4A:
undetectable
4c5lD-1wl4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 10 GLY A  58
ALA A 260
GLY A 117
VAL A  70
MET A 119
None
1.41A 4c5nD-1wl4A:
undetectable
4c5nD-1wl4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 7 LEU A 382
ASN A 321
ALA A 323
ILE A 146
CSO  A  92 ( 3.9A)
None
COA  A1001 ( 3.8A)
None
0.98A 4eyrA-1wl4A:
undetectable
4eyrA-1wl4A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 8 ALA A 260
VAL A 115
GLY A 118
ALA A 258
GLY A  34
None
1.36A 4zjzB-1wl4A:
undetectable
4zjzB-1wl4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
3 / 3 ILE A 390
ILE A 362
MET A  90
None
0.68A 5i9yA-1wl4A:
undetectable
5i9yA-1wl4A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 ILE A 280
THR A 365
GLU A 319
ALA A 308
ILE A 390
None
1.41A 5iwuA-1wl4A:
undetectable
5iwuA-1wl4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 5 PRO A 297
ALA A 381
ALA A 300
ILE A 301
LEU A 335
None
1.47A 5jncD-1wl4A:
undetectable
5jncD-1wl4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 GLN A 186
ARG A 361
PRO A 354
ASN A 255
ILE A  18
COA  A1001 (-4.3A)
None
None
None
None
1.20A 5uhdC-1wl4A:
0.0
5uhdC-1wl4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 9 CYH A 383
GLY A 296
GLY A 294
ALA A 330
VAL A 327
COA  A1001 ( 4.6A)
None
None
None
None
1.29A 5v3cA-1wl4A:
0.0
5v3cA-1wl4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
5 / 12 THR A 306
LEU A  96
TRP A 310
LEU A 366
VAL A 394
None
1.30A 6a93B-1wl4A:
undetectable
6a93B-1wl4A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 4 LEU A 351
ASP A 219
GLN A 193
VAL A 315
None
1.48A 6bzoF-1wl4A:
0.0
6bzoF-1wl4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
4 / 8 ILE A  17
THR A  16
THR A 365
SER A 358
None
1.13A 6c06C-1wl4A:
undetectable
6c06C-1wl4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo
sapiens)
3 / 3 VAL A  55
GLU A  54
ILE A  79
None
0.65A 6f7lB-1wl4A:
undetectable
6f7lB-1wl4A:
21.46