SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		3 / 3 TRP A 305
TYR A 312
LEU A 259
 None
 0.82A 1kxhA-1wl7A:
undetectable		 1kxhA-1wl7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 8 GLY A  45
SER A 100
ASP A 147
ASP A  27
 None
 0.83A 1m4iA-1wl7A:
undetectable		 1m4iA-1wl7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 6 ASP A 238
ILE A 239
GLN A 173
GLU A 155
 None
 1.02A 2ya7C-1wl7A:
1.5		 2ya7C-1wl7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 5 ILE A 300
PHE A   7
PRO A  28
PHE A  40
 None
 1.22A 2ygnA-1wl7A:
undetectable		 2ygnA-1wl7A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 9 ILE A 300
ILE A  30
PHE A   7
PRO A 302
PHE A 204
 None
 1.37A 2ygpA-1wl7A:
0.0		 2ygpA-1wl7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A 282
ASN A 263
ALA A 273
VAL A  39
LEU A 298
 None
 1.21A 3a51E-1wl7A:
0.0		 3a51E-1wl7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 8 LEU A 171
ILE A 205
PHE A 215
GLY A 234
 None
 0.97A 3b9lA-1wl7A:
undetectable		 3b9lA-1wl7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		3 / 3 GLU A 295
HIS A 286
HIS A  41
 None
 0.93A 3co4A-1wl7A:
undetectable		 3co4A-1wl7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A 268
GLY A 262
SER A 217
ALA A 287
ASN A 285
 None
 1.14A 3kkzA-1wl7A:
undetectable		 3kkzA-1wl7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 7 ARG A 208
ALA A 281
VAL A 206
VAL A 274
LEU A 303
 None
 1.02A 3o14A-1wl7A:
undetectable		 3o14A-1wl7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A 268
GLY A 262
SER A 217
ALA A 287
ASN A 285
 None
 1.20A 3sxjA-1wl7A:
undetectable		 3sxjA-1wl7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A 268
GLY A 262
SER A 217
ALA A 287
ASN A 285
 None
 1.20A 3sxjB-1wl7A:
undetectable		 3sxjB-1wl7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A 268
GLY A 262
SER A 217
ALA A 287
ASN A 285
 None
 1.16A 3t7sA-1wl7A:
undetectable		 3t7sA-1wl7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A 268
GLY A 262
SER A 217
ALA A 287
ASN A 285
 None
 1.17A 3t7sC-1wl7A:
undetectable		 3t7sC-1wl7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A 268
GLY A 262
SER A 217
ALA A 287
ASN A 285
 None
 1.18A 3t7sD-1wl7A:
undetectable		 3t7sD-1wl7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 11 ASN A 144
PHE A 162
ASN A 149
GLY A 163
GLY A 112
 None
 1.15A 4a6nC-1wl7A:
undetectable		 4a6nC-1wl7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		5 / 11 ASN A 144
PHE A 162
ASN A 149
GLY A 163
GLY A 112
 None
 1.12A 4a99C-1wl7A:
undetectable		 4a99C-1wl7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		3 / 3 ASP A 147
TRP A  24
SER A 217
 None
 1.05A 4lrhA-1wl7A:
undetectable		 4lrhA-1wl7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 5 TYR A  74
PHE A  64
LEU A 113
PRO A  68
 None
 0.98A 5csyB-1wl7A:
undetectable		 5csyB-1wl7A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		3 / 3 TRP A 166
ILE A 146
SER A 102
 None
 0.99A 5gqbA-1wl7A:
undetectable		 5gqbA-1wl7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		3 / 3 TRP A 166
ILE A 146
SER A 109
 None
 0.96A 5gqbA-1wl7A:
undetectable		 5gqbA-1wl7A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		3 / 3 PHE A 104
ARG A 223
ALA A 199
 None
 0.94A 6ecfB-1wl7A:
undetectable		 6ecfB-1wl7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 6 ILE A 205
LEU A 171
VAL A 151
SER A 161
 None
 1.30A 6f6jA-1wl7A:
undetectable		 6f6jA-1wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 4 ASP A  81
ILE A  46
PRO A  86
LEU A  83
 None
 1.28A 6mkeB-1wl7A:
undetectable		 6mkeB-1wl7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1wl7 ARABINANASE-TS
(Geobacillus
thermodenitrific
ans) 		4 / 4 ASP A  81
ILE A  46
PRO A  86
LEU A  83
 None
 1.33A 6mkeA-1wl7A:
undetectable		 6mkeA-1wl7A:
14.38