SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 GLY A 162
LEU A  76
PRO A 167
ALA A 143
PHE A 115
 None
 1.13A 1gseA-1wl8A:
2.0		 1gseA-1wl8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 LEU A 118
ILE A 106
PHE A 165
ILE A 178
TYR A 161
 None
None
None
None
SNN  A 112 ( 4.4A)
 1.46A 1ot7B-1wl8A:
0.0		 1ot7B-1wl8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		4 / 6 PHE A 182
TYR A  68
GLY A  46
LYS A  45
 None
 1.26A 2i30A-1wl8A:
0.0		 2i30A-1wl8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 PRO A 167
GLY A  81
GLY A  51
ILE A 114
GLY A  77
 None
None
CL  A1202 ( 3.7A)
SNN  A 112 ( 4.2A)
None
 1.04A 3axzA-1wl8A:
undetectable		 3axzA-1wl8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		4 / 8 GLU A 113
PHE A 139
ILE A 150
VAL A 132
 SNN  A 112 ( 3.2A)
None
None
None
 0.94A 4dx7B-1wl8A:
undetectable		 4dx7B-1wl8A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		4 / 7 GLY A  51
GLY A  52
ASN A  57
GLU A 168
 CL  A1202 ( 3.7A)
None
None
None
 1.04A 4fgkB-1wl8A:
5.1		 4fgkB-1wl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 10 GLY A  77
GLY A 162
VAL A  64
PHE A  89
PHE A 139
 None
 1.47A 4fgkA-1wl8A:
5.0
4fgkB-1wl8A:
5.1		 4fgkA-1wl8A:
20.85
4fgkB-1wl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		4 / 7 VAL A  64
PHE A  89
ILE A  85
PHE A 139
 None
 0.81A 4fglC-1wl8A:
4.9		 4fglC-1wl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 PHE A 115
ILE A 106
ALA A 152
THR A  19
LEU A 118
 None
 1.02A 4qztC-1wl8A:
undetectable		 4qztC-1wl8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 PHE A 115
ILE A 106
ALA A 152
THR A  19
LEU A 118
 None
 1.02A 4qzuA-1wl8A:
undetectable		 4qzuA-1wl8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 PHE A 115
ILE A 106
ALA A 152
THR A  19
LEU A 118
 None
 1.03A 4qzuC-1wl8A:
undetectable		 4qzuC-1wl8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 8 ILE A  29
VAL A 124
ILE A 178
ILE A 106
ILE A 114
 None
None
None
None
SNN  A 112 ( 4.2A)
 1.31A 5hi2A-1wl8A:
undetectable		 5hi2A-1wl8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 GLY A  77
ARG A  95
GLY A  96
GLY A  52
GLY A  51
 None
None
None
None
CL  A1202 ( 3.7A)
 0.90A 5koxA-1wl8A:
undetectable		 5koxA-1wl8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 12 ILE A 106
ILE A 108
VAL A 124
GLU A 177
ILE A 178
 None
 1.07A 5lg3E-1wl8A:
undetectable		 5lg3E-1wl8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A
(Pyrococcus
horikoshii) 		5 / 10 ILE A 106
ILE A 108
VAL A 124
GLU A 177
ILE A 178
 None
 1.11A 5lg3H-1wl8A:
undetectable		 5lg3H-1wl8A:
20.39