SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1wlc CONGERIN II
(Conger
myriaster) 		4 / 8 VAL A  19
VAL A  34
ILE A  99
LEU A  17
 None
 0.86A 1igxA-1wlcA:
undetectable		 1igxA-1wlcA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1wlc CONGERIN II
(Conger
myriaster) 		5 / 6 HIS A  44
ARG A  48
ASN A  61
TRP A  69
GLU A  72
 MES  A 777 ( 4.6A)
None
None
None
None
 0.20A 3galA-1wlcA:
19.5		 3galA-1wlcA:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 1wlc CONGERIN II
(Conger
myriaster) 		5 / 6 HIS A  44
ARG A  48
ASN A  61
TRP A  69
GLU A  72
 MES  A 777 ( 4.6A)
None
None
None
None
 0.27A 3galB-1wlcA:
19.1		 3galB-1wlcA:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1wlc CONGERIN II
(Conger
myriaster) 		4 / 5 TYR A  98
ILE A  99
ASN A 111
ILE A  90
 None
 1.05A 4jtpA-1wlcA:
undetectable		 4jtpA-1wlcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1wlc CONGERIN II
(Conger
myriaster) 		3 / 3 ASN A  33
SER A  31
ARG A  29
 MES  A 777 ( 3.9A)
MES  A 777 ( 4.0A)
None
 0.92A 5b2qA-1wlcA:
undetectable		 5b2qA-1wlcA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1wlc CONGERIN II
(Conger
myriaster) 		5 / 12 ILE A  41
GLY A  35
TYR A 122
ASP A  46
ILE A  99
 None
None
MES  A 777 (-4.8A)
None
None
 1.44A 5igwA-1wlcA:
0.7		 5igwA-1wlcA:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1wlc CONGERIN II
(Conger
myriaster) 		6 / 7 HIS A  44
ARG A  48
ASN A  61
TRP A  69
GLU A  72
ARG A  74
 MES  A 777 ( 4.6A)
None
None
None
None
None
 0.50A 6b8kA-1wlcA:
19.5		 6b8kA-1wlcA:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1wlc CONGERIN II
(Conger
myriaster) 		6 / 8 HIS A  44
ARG A  48
ASN A  61
TRP A  69
GLU A  72
ARG A  74
 MES  A 777 ( 4.6A)
None
None
None
None
None
 0.51A 6b94A-1wlcA:
24.0		 6b94A-1wlcA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 1wlc CONGERIN II
(Conger
myriaster) 		7 / 10 HIS A  44
ARG A  48
ASP A  54
ASN A  61
TRP A  69
GLU A  72
ARG A  74
 MES  A 777 ( 4.6A)
None
None
None
None
None
None
 0.63A 6b94A-1wlcA:
24.0
6b94B-1wlcA:
23.5		 6b94A-1wlcA:
29.89
6b94B-1wlcA:
29.89