SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 GLU A 143
LEU A  79
ARG A  83
ARG A  32
TYR A  28
 None
 1.46A 1l7fA-1wleA:
undetectable		 1l7fA-1wleA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 LEU A  59
ALA A  56
LEU A 153
PRO A 154
LEU A 381
 None
 1.22A 1og5A-1wleA:
undetectable		 1og5A-1wleA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 LEU A  59
ALA A  56
LEU A 153
PRO A 154
LEU A 381
 None
 1.22A 1og5B-1wleA:
undetectable		 1og5B-1wleA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		6 / 9 LEU A 468
VAL A 458
ILE A 191
PRO A 461
VAL A 460
ILE A 473
 None
 1.33A 1ohrB-1wleA:
undetectable		 1ohrB-1wleA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 5 LEU A  57
ASP A  58
PRO A  50
ALA A  53
 None
 0.94A 2aofB-1wleA:
undetectable		 2aofB-1wleA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 GLU A 143
LEU A  79
ARG A  83
ARG A  32
TYR A  28
 None
 1.50A 2htuA-1wleA:
undetectable		 2htuA-1wleA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 8 LEU A 225
GLY A 216
ILE A 197
LEU A 464
 None
 0.77A 2o4nB-1wleA:
undetectable		 2o4nB-1wleA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 5 SER A 347
GLY A 343
ASP A 293
ASP A 410
 None
 1.10A 2oxtB-1wleA:
undetectable		 2oxtB-1wleA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ASP A  42
ARG A 414
ILE A 418
ILE A 303
GLY A 343
 None
 1.15A 2v0mA-1wleA:
0.8		 2v0mA-1wleA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 VAL A 402
ILE A 389
LEU A 233
GLN A 358
PHE A 228
 SRP  A 900 (-4.4A)
None
None
None
None
 1.46A 3apwB-1wleA:
undetectable		 3apwB-1wleA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 5 ILE A 445
HIS A 188
ARG A 398
GLY A 395
 None
 1.24A 3b9mA-1wleA:
3.7		 3b9mA-1wleA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 7 VAL A  96
VAL A 100
LEU A 103
VAL A 112
 None
 0.82A 3hs6B-1wleA:
undetectable		 3hs6B-1wleA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		3 / 3 GLN A 465
THR A 470
LEU A 448
 None
 0.69A 3ondA-1wleA:
undetectable		 3ondA-1wleA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		3 / 3 GLN A 465
THR A 470
LEU A 448
 None
 0.70A 3ondB-1wleA:
undetectable		 3ondB-1wleA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 GLY A 254
GLY A 289
ALA A 288
ALA A 283
SER A 309
 None
 1.00A 3sudD-1wleA:
undetectable		 3sudD-1wleA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 6 THR A 432
GLY A 338
ILE A 303
LEU A 287
 None
 0.98A 4ac9C-1wleA:
undetectable		 4ac9C-1wleA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 6 THR A 432
GLY A 338
ILE A 303
LEU A 287
 None
 0.94A 4acaC-1wleA:
undetectable		 4acaC-1wleA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 6 THR A 432
GLY A 338
ILE A 303
LEU A 287
 None
 0.94A 4acbC-1wleA:
undetectable		 4acbC-1wleA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 ASN A 407
LEU A 355
GLN A 358
ALA A 435
GLU A 335
 None
None
None
None
SRP  A 900 (-2.8A)
 1.28A 4ejwA-1wleA:
0.3		 4ejwA-1wleA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 8 ARG A 313
ARG A 327
PHE A 331
ARG A 442
 SRP  A 900 (-2.6A)
None
SRP  A 900 (-4.0A)
SRP  A 900 ( 4.1A)
 0.89A 4k87A-1wleA:
23.6		 4k87A-1wleA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 7 THR A 403
ALA A 405
LEU A 351
LEU A 350
 None
 0.85A 4ubsA-1wleA:
2.1		 4ubsA-1wleA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		3 / 3 VAL A 226
LEU A 230
VAL A 334
 None
 0.56A 4wq4A-1wleA:
undetectable		 4wq4A-1wleA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		6 / 9 LEU A 225
LEU A 447
ALA A 446
LEU A 367
ALA A 391
LEU A 362
 None
 1.24A 4z91F-1wleA:
5.0
4z91G-1wleA:
4.9
4z91H-1wleA:
4.9
4z91I-1wleA:
5.0
4z91J-1wleA:
4.9		 4z91F-1wleA:
20.04
4z91G-1wleA:
20.04
4z91H-1wleA:
20.04
4z91I-1wleA:
20.04
4z91J-1wleA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		6 / 9 LEU A 367
ALA A 391
LEU A 362
LEU A 225
LEU A 447
ALA A 446
 None
 1.18A 4z91F-1wleA:
5.0
4z91G-1wleA:
4.9
4z91H-1wleA:
4.9
4z91I-1wleA:
5.0
4z91J-1wleA:
4.9		 4z91F-1wleA:
20.04
4z91G-1wleA:
20.04
4z91H-1wleA:
20.04
4z91I-1wleA:
20.04
4z91J-1wleA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		4 / 6 TYR A 326
GLY A 319
GLU A 315
ARG A 210
 None
None
SRP  A 900 (-3.5A)
None
 1.23A 4zbqA-1wleA:
2.3		 4zbqA-1wleA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		3 / 3 ASP A 245
ASN A 278
PHE A 274
 None
 0.68A 5dsgB-1wleA:
2.7		 5dsgB-1wleA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 LEU A 357
GLY A 338
LEU A 287
ARG A 236
GLU A 335
 None
None
None
None
SRP  A 900 (-2.8A)
 1.17A 5emlA-1wleA:
undetectable		 5emlA-1wleA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ILE A 473
ILE A 197
VAL A 458
GLU A 190
ILE A 191
 None
 1.16A 5lg3G-1wleA:
undetectable		 5lg3G-1wleA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ILE A 473
ILE A 197
VAL A 458
GLU A 190
ILE A 191
 None
 1.17A 5lg3H-1wleA:
undetectable		 5lg3H-1wleA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 LEU A 225
ILE A 473
ILE A 445
VAL A 458
ILE A 191
 None
 0.95A 5mugA-1wleA:
undetectable		 5mugA-1wleA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 ILE A 197
GLY A 216
ILE A 191
ALA A 192
VAL A 458
 None
 1.02A 5n0sA-1wleA:
undetectable		 5n0sA-1wleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 ILE A 197
GLY A 216
ILE A 191
ALA A 192
VAL A 458
 None
 1.07A 5n0tA-1wleA:
undetectable		 5n0tA-1wleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 ILE A 197
GLY A 216
ILE A 191
ALA A 192
VAL A 458
 None
 1.07A 5n0wB-1wleA:
undetectable		 5n0wB-1wleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 ILE A 197
GLY A 216
ILE A 191
ALA A 192
VAL A 458
 None
 1.10A 5n0xA-1wleA:
undetectable		 5n0xA-1wleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 ILE A 197
GLY A 216
ILE A 191
ALA A 192
VAL A 458
 None
 1.06A 5n4iA-1wleA:
undetectable		 5n4iA-1wleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 12 GLN A 421
ALA A 297
SER A 295
LEU A 427
ASP A 293
 None
 1.28A 5vlmA-1wleA:
2.2		 5vlmA-1wleA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ARG A 313
GLU A 315
PHE A 331
ALA A 439
GLU A 401
 SRP  A 900 (-2.6A)
SRP  A 900 (-3.5A)
SRP  A 900 (-4.0A)
SRP  A 900 (-3.5A)
SRP  A 900 (-3.6A)
 1.15A 6bniA-1wleA:
10.8		 6bniA-1wleA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ARG A 313
GLU A 315
PHE A 331
GLU A 401
ARG A 442
 SRP  A 900 (-2.6A)
SRP  A 900 (-3.5A)
SRP  A 900 (-4.0A)
SRP  A 900 (-3.6A)
SRP  A 900 ( 4.1A)
 0.71A 6bniA-1wleA:
10.8		 6bniA-1wleA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ARG A 313
GLU A 315
PHE A 331
ALA A 439
GLU A 401
 SRP  A 900 (-2.6A)
SRP  A 900 (-3.5A)
SRP  A 900 (-4.0A)
SRP  A 900 (-3.5A)
SRP  A 900 (-3.6A)
 1.20A 6bniB-1wleA:
12.1		 6bniB-1wleA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 10 ARG A 313
GLU A 315
PHE A 331
GLU A 401
ARG A 442
 SRP  A 900 (-2.6A)
SRP  A 900 (-3.5A)
SRP  A 900 (-4.0A)
SRP  A 900 (-3.6A)
SRP  A 900 ( 4.1A)
 0.72A 6bniB-1wleA:
12.1		 6bniB-1wleA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1wle SERYL-TRNA
SYNTHETASE
(Bos
taurus) 		5 / 8 LEU A 362
GLN A 358
THR A 229
VAL A 440
LEU A 443
 None
 1.41A 6czmD-1wleA:
undetectable
6czmF-1wleA:
undetectable		 6czmD-1wleA:
23.65
6czmF-1wleA:
23.65