SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 9 PHE A 187
TYR A 188
VAL A 150
GLY A 149
VAL A 171
 None
 1.46A 1dz8A-1wlsA:
undetectable		 1dz8A-1wlsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 9 PHE A 187
TYR A 188
VAL A 150
GLY A 149
VAL A 171
 None
 1.46A 1dz9B-1wlsA:
undetectable		 1dz9B-1wlsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 230
LEU A 229
VAL A 257
LEU A 299
 None
 1.03A 1hk3A-1wlsA:
undetectable		 1hk3A-1wlsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.13A 1kiaB-1wlsA:
undetectable		 1kiaB-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.12A 1kiaC-1wlsA:
undetectable		 1kiaC-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.12A 1nbhA-1wlsA:
undetectable		 1nbhA-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.11A 1nbhB-1wlsA:
undetectable		 1nbhB-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.13A 1nbhC-1wlsA:
undetectable		 1nbhC-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.11A 1nbhD-1wlsA:
undetectable		 1nbhD-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 9 PRO A 112
PRO A 121
SER A 118
LEU A  25
THR A 114
 None
 1.45A 1urmA-1wlsA:
undetectable		 1urmA-1wlsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 11 SER A 165
GLY A 149
VAL A 150
ILE A 138
HIS A 183
 None
 1.13A 1vhwC-1wlsA:
4.1
1vhwE-1wlsA:
undetectable		 1vhwC-1wlsA:
22.66
1vhwE-1wlsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A 183
SER A 165
GLY A 149
VAL A 150
ILE A 138
 None
 1.12A 1vhwA-1wlsA:
4.2
1vhwD-1wlsA:
4.1		 1vhwA-1wlsA:
22.66
1vhwD-1wlsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A  44
LEU A 128
SER A  28
LEU A  31
LYS A  32
 None
 1.14A 2ceoB-1wlsA:
undetectable		 2ceoB-1wlsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A 270
ALA A 287
ILE A 285
GLY A 317
LEU A 280
 None
 1.44A 2o4nB-1wlsA:
undetectable		 2o4nB-1wlsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A 100
GLY A 137
TYR A 188
 None
 0.73A 2vouA-1wlsA:
undetectable		 2vouA-1wlsA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A 100
GLY A 137
TYR A 188
 None
 0.72A 2vouB-1wlsA:
undetectable		 2vouB-1wlsA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A  88
SER A  89
ILE A 140
SER A  52
 None
 1.08A 2xz5B-1wlsA:
undetectable
2xz5E-1wlsA:
undetectable		 2xz5B-1wlsA:
18.69
2xz5E-1wlsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 4 ARG A   2
ASP A  75
LEU A 128
ARG A  45
 None
 1.31A 2ziaB-1wlsA:
0.0		 2ziaB-1wlsA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  84
THR A 261
GLU A 293
 None
 0.63A 2zifB-1wlsA:
undetectable		 2zifB-1wlsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A 286
LEU A 280
ARG A 277
 None
 0.73A 3aqiA-1wlsA:
4.7		 3aqiA-1wlsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A  78
GLY A 108
THR A 107
GLY A  82
 None
 0.74A 3aruA-1wlsA:
undetectable		 3aruA-1wlsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 244
LEU A 229
VAL A 257
ILE A 215
LEU A 203
 None
 1.18A 3jw5B-1wlsA:
undetectable		 3jw5B-1wlsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 213
VAL A 248
GLY A 210
LEU A 207
ILE A 205
 None
 0.81A 3ku1A-1wlsA:
undetectable		 3ku1A-1wlsA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 213
VAL A 248
GLY A 210
LEU A 207
ILE A 205
 None
 0.77A 3ku1C-1wlsA:
undetectable		 3ku1C-1wlsA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  79
VAL A 171
ILE A 184
ILE A 104
ALA A  90
 None
 1.09A 3ohtA-1wlsA:
undetectable
3ohtB-1wlsA:
undetectable		 3ohtA-1wlsA:
22.52
3ohtB-1wlsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 7 PRO A 100
ILE A 138
LEU A 106
ILE A  77
 None
 0.80A 3p50A-1wlsA:
undetectable		 3p50A-1wlsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 7 PRO A 100
ILE A 138
LEU A 106
ILE A  77
 None
 0.81A 3p50B-1wlsA:
undetectable		 3p50B-1wlsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 7 PRO A 100
ILE A 138
LEU A 106
ILE A  77
 None
 0.79A 3p50C-1wlsA:
undetectable		 3p50C-1wlsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 7 PRO A 100
ILE A 138
LEU A 106
ILE A  77
 None
 0.80A 3p50D-1wlsA:
undetectable		 3p50D-1wlsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 7 PRO A 100
ILE A 138
LEU A 106
ILE A  77
 None
 0.80A 3p50E-1wlsA:
undetectable		 3p50E-1wlsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A 213
VAL A 216
SER A 212
ASP A 243
VAL A 247
 None
 1.46A 4da6A-1wlsA:
4.0		 4da6A-1wlsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 255
ALA A 219
THR A 242
LEU A 207
LEU A 229
 None
 1.08A 4qzuC-1wlsA:
undetectable		 4qzuC-1wlsA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  63
TRP A  60
LEU A  93
THR A 297
 None
 1.19A 5hs6A-1wlsA:
undetectable		 5hs6A-1wlsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		6 / 12 LEU A 299
THR A 297
ALA A 294
ILE A 302
LEU A 315
MET A 316
 None
 1.28A 5nfjA-1wlsA:
undetectable		 5nfjA-1wlsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1wls L-ASPARAGINASE
(Pyrococcus
horikoshii) 		4 / 8 THR A  83
GLY A  82
GLY A  10
SER A  14
 None
 0.73A 5vw9A-1wlsA:
undetectable		 5vw9A-1wlsA:
21.82