SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.97A 1m8eB-1wltA:
undetectable		 1m8eB-1wltA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.95A 1nodB-1wltA:
undetectable		 1nodB-1wltA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.98A 1qomA-1wltA:
undetectable		 1qomA-1wltA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  75
LEU A  14
ALA A 100
VAL A  98
ALA A  84
 None
 0.97A 1sa1C-1wltA:
undetectable
1sa1D-1wltA:
undetectable		 1sa1C-1wltA:
16.89
1sa1D-1wltA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A 128
SER A  50
ARG A  58
HIS A  61
 None
 0.96A 2f78A-1wltA:
undetectable		 2f78A-1wltA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 6 VAL A 128
SER A  50
ARG A  58
HIS A  61
 None
 0.87A 2f8dA-1wltA:
undetectable		 2f8dA-1wltA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.95A 2nodB-1wltA:
undetectable		 2nodB-1wltA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.93A 3e68A-1wltA:
undetectable		 3e68A-1wltA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.95A 3e6tB-1wltA:
undetectable		 3e6tB-1wltA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.95A 3e7iB-1wltA:
undetectable		 3e7iB-1wltA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 4 ILE A  72
PHE A  36
ILE A  15
THR A 133
 None
 1.12A 3ia4A-1wltA:
undetectable		 3ia4A-1wltA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 4 PHE A  36
LYS A  32
ILE A  15
THR A 133
 None
 1.45A 3ia4B-1wltA:
undetectable		 3ia4B-1wltA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 1.03A 3nw2A-1wltA:
undetectable		 3nw2A-1wltA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  40
ILE A  13
TRP A 111
 None
 0.98A 3nw2B-1wltA:
undetectable		 3nw2B-1wltA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 6 TYR A 130
GLN A  46
ILE A 132
SER A  50
 None
 1.16A 3pmzD-1wltA:
undetectable		 3pmzD-1wltA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A  68
PHE A 175
GLN A  63
 None
 0.98A 3r55A-1wltA:
undetectable		 3r55A-1wltA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 7 ALA A  84
GLY A  70
ILE A  72
ILE A  73
 None
 0.67A 4eatA-1wltA:
undetectable		 4eatA-1wltA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A  72
PHE A  36
LYS A  32
ILE A  15
THR A 133
 None
 1.38A 4p68A-1wltA:
undetectable		 4p68A-1wltA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Sulfurisphaera
tokodaii) 		4 / 5 TYR A 130
LYS A  71
GLY A  55
ILE A  80
 None
 1.27A 6debB-1wltA:
undetectable		 6debB-1wltA:
18.09