SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		3 / 3 LEU A 113
PRO A 114
LEU A 178
 None
 0.44A 1hrkA-1wm9A:
undetectable		 1hrkA-1wm9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		5 / 10 ILE A 138
VAL A  99
VAL A 171
TYR A 123
LEU A 130
 None
 1.40A 1s1uA-1wm9A:
undetectable		 1s1uA-1wm9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		3 / 3 LEU A 113
PRO A 114
LEU A 178
 None
 0.61A 2po5B-1wm9A:
undetectable		 2po5B-1wm9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		3 / 3 LEU A 113
PRO A 114
LEU A 178
 None
 0.48A 3w1wB-1wm9A:
undetectable		 3w1wB-1wm9A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		4 / 8 LEU A 215
ILE A 121
VAL A 139
GLY A 101
 None
 0.88A 4eq4B-1wm9A:
undetectable		 4eq4B-1wm9A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		4 / 8 VAL A 154
ALA A 196
GLY A 170
GLY A 199
 None
 0.80A 5e26C-1wm9A:
undetectable
5e26D-1wm9A:
undetectable		 5e26C-1wm9A:
20.71
5e26D-1wm9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		3 / 3 MET A 197
GLU A 209
ARG A 208
 None
 0.90A 5tjzA-1wm9A:
undetectable		 5tjzA-1wm9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1wm9 GTP CYCLOHYDROLASE I
(Thermus
thermophilus) 		3 / 3 LEU A 152
VAL A 139
ASP A 140
 None
 0.64A 5x23A-1wm9A:
undetectable		 5x23A-1wm9A:
18.83