SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 8 LEU A 261
ALA A 257
LEU A 284
THR A 237
None
0.96A 1dvtA-1wmwA:
undetectable
1dvtB-1wmwA:
undetectable
1dvtA-1wmwA:
16.72
1dvtB-1wmwA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 12 LEU A 325
PRO A 181
LEU A  68
VAL A 211
ASP A 212
None
1.36A 1mrlB-1wmwA:
undetectable
1mrlC-1wmwA:
undetectable
1mrlB-1wmwA:
17.40
1mrlC-1wmwA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ARG A  88
TYR A 176
GLN A 209
ASP A 212
None
0.97A 1yhlA-1wmwA:
32.4
1yhlA-1wmwA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.36A 1yhlA-1wmwA:
32.4
1yhlA-1wmwA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.98A 1yhlA-1wmwA:
32.4
1yhlA-1wmwA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ARG A  88
TYR A 176
GLN A 209
ASP A 212
None
0.91A 1yq7A-1wmwA:
32.2
1yq7A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ASP A  79
ASP A  83
GLN A 146
GLN A 209
None
1.41A 1yq7A-1wmwA:
32.2
1yq7A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ASP A  79
ASP A  83
TYR A 176
GLN A 209
None
1.00A 1yq7A-1wmwA:
32.2
1yq7A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.01A 1yq7A-1wmwA:
32.2
1yq7A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.59A 1yq7A-1wmwA:
32.2
1yq7A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ARG A  88
GLN A 146
GLN A 209
None
1.31A 1yv5A-1wmwA:
32.5
1yv5A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
0.85A 1yv5A-1wmwA:
32.5
1yv5A-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.41A 2e91A-1wmwA:
25.8
2e91A-1wmwA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.96A 2f89F-1wmwA:
33.0
2f89F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ARG A  88
TYR A 176
GLN A 209
ASP A 212
None
0.96A 2f8cF-1wmwA:
32.5
2f8cF-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ASP A  79
ARG A  88
GLN A 146
GLN A 209
None
1.32A 2f8cF-1wmwA:
32.5
2f8cF-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.89A 2f8cF-1wmwA:
32.5
2f8cF-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ARG A  88
GLN A 146
GLN A 209
None
1.35A 2f8zF-1wmwA:
32.9
2f8zF-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
0.84A 2f8zF-1wmwA:
32.9
2f8zF-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ARG A  88
THR A 142
TYR A 176
GLN A 209
ASP A 212
None
0.87A 2f94F-1wmwA:
32.4
2f94F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
7 / 12 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
TYR A 176
GLN A 209
None
0.96A 2f94F-1wmwA:
32.4
2f94F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
7 / 12 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 146
TYR A 176
GLN A 209
None
0.54A 2f94F-1wmwA:
32.4
2f94F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.33A 2f9kF-1wmwA:
32.3
2f9kF-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 7 GLU A  87
PRO A  35
ARG A  37
GLY A 224
None
1.24A 2hs1B-1wmwA:
undetectable
2hs1B-1wmwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.36A 2o1oB-1wmwA:
28.1
2o1oB-1wmwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  83
ARG A  88
GLN A 209
ASP A 213
None
0.67A 2q58A-1wmwA:
27.4
2q58A-1wmwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.33A 2qisA-1wmwA:
32.5
2qisA-1wmwA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 8 GLY A  44
ALA A  65
GLY A 185
LEU A 182
VAL A 138
None
1.34A 3em6A-1wmwA:
undetectable
3em6A-1wmwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ASP A  83
GLN A 146
GLN A 209
None
1.48A 3ez3D-1wmwA:
31.6
3ez3D-1wmwA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.10A 3ez3D-1wmwA:
31.6
3ez3D-1wmwA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
1.07A 3ibaA-1wmwA:
32.0
3ibaA-1wmwA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 12 ARG A 124
GLY A 121
GLY A  61
SER A  50
ALA A  64
None
0.93A 3kkzB-1wmwA:
undetectable
3kkzB-1wmwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
3 / 3 ARG A 328
ASP A 230
GLN A 146
None
0.73A 3lcvB-1wmwA:
undetectable
3lcvB-1wmwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.49A 3ldwD-1wmwA:
31.5
3ldwD-1wmwA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ARG A  88
TYR A 176
GLN A 209
ASP A 212
None
0.98A 3n45F-1wmwA:
32.4
3n45F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.32A 3n45F-1wmwA:
32.4
3n45F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.97A 3n45F-1wmwA:
32.4
3n45F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ASP A  83
GLN A 146
GLN A 209
None
1.40A 3n46F-1wmwA:
32.5
3n46F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.05A 3n46F-1wmwA:
32.5
3n46F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 5 LEU A  46
LEU A 204
GLY A 205
GLY A 201
None
0.82A 3si7C-1wmwA:
undetectable
3si7D-1wmwA:
undetectable
3si7C-1wmwA:
20.16
3si7D-1wmwA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.13A 4e47A-1wmwA:
undetectable
4e47A-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.17A 4e47B-1wmwA:
undetectable
4e47B-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.15A 4e47C-1wmwA:
undetectable
4e47C-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 12 LEU A 315
ALA A 305
ALA A 186
GLY A 190
ALA A  53
None
1.16A 4enhA-1wmwA:
0.1
4enhA-1wmwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.19A 4jdsA-1wmwA:
undetectable
4jdsA-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.16A 4jdsB-1wmwA:
undetectable
4jdsB-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.16A 4jdsC-1wmwA:
undetectable
4jdsC-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 12 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.09A 4jlgA-1wmwA:
undetectable
4jlgA-1wmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  79
ASP A  83
GLN A 146
GLN A 209
None
1.41A 4kfaA-1wmwA:
32.6
4kfaA-1wmwA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.01A 4kfaA-1wmwA:
32.6
4kfaA-1wmwA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.33A 4kpdA-1wmwA:
33.1
4kpdA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
0.90A 4kpjA-1wmwA:
32.4
4kpjA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ASP A  83
GLN A 146
GLN A 209
None
1.41A 4kq5A-1wmwA:
32.7
4kq5A-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.02A 4kq5A-1wmwA:
32.7
4kq5A-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.31A 4kqsA-1wmwA:
33.2
4kqsA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ARG A  88
THR A 142
GLN A 209
ASP A 212
None
0.93A 4n9uA-1wmwA:
32.2
4n9uA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.33A 4n9uA-1wmwA:
32.2
4n9uA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 209
None
0.52A 4n9uA-1wmwA:
32.2
4n9uA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ARG A  88
THR A 142
TYR A 176
GLN A 209
ASP A 212
None
0.91A 4ng6A-1wmwA:
32.5
4ng6A-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
7 / 12 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
TYR A 176
GLN A 209
None
0.99A 4ng6A-1wmwA:
32.5
4ng6A-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
7 / 12 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 146
TYR A 176
GLN A 209
None
0.60A 4ng6A-1wmwA:
32.5
4ng6A-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.31A 4nkeA-1wmwA:
32.8
4nkeA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
0.90A 4nkfA-1wmwA:
32.2
4nkfA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.30A 4nuaA-1wmwA:
32.9
4nuaA-1wmwA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
0.88A 4oguA-1wmwA:
32.5
4oguA-1wmwA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.40A 4p0vA-1wmwA:
32.5
4p0vA-1wmwA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  76
ARG A  88
TYR A 176
GLN A 209
ASP A 212
None
0.99A 4p0wA-1wmwA:
32.8
4p0wA-1wmwA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.30A 4p0wA-1wmwA:
32.8
4p0wA-1wmwA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 11 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.94A 4p0wA-1wmwA:
32.8
4p0wA-1wmwA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ARG A  88
TYR A 176
GLN A 209
ASP A 212
None
0.92A 4q23A-1wmwA:
32.3
4q23A-1wmwA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.35A 4q23A-1wmwA:
32.3
4q23A-1wmwA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.95A 4q23A-1wmwA:
32.3
4q23A-1wmwA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.37A 4rxdA-1wmwA:
32.0
4rxdA-1wmwA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.35A 4rxdB-1wmwA:
32.4
4rxdB-1wmwA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ARG A  88
GLN A 146
GLN A 209
None
1.42A 4rxdC-1wmwA:
32.3
4rxdC-1wmwA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
0.91A 4rxdC-1wmwA:
32.3
4rxdC-1wmwA:
27.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 8 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
None
1.13A 4umjA-1wmwA:
26.1
4umjA-1wmwA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
None
1.23A 4umjB-1wmwA:
26.2
4umjB-1wmwA:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  42
ARG A  43
LEU A  46
GLU A 327
LEU A 322
None
1.08A 4wg0B-1wmwA:
undetectable
4wg0C-1wmwA:
undetectable
4wg0D-1wmwA:
undetectable
4wg0B-1wmwA:
3.13
4wg0C-1wmwA:
3.13
4wg0D-1wmwA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 LEU A  42
ARG A  43
LEU A  46
GLU A 327
LEU A 322
None
1.07A 4wg0D-1wmwA:
undetectable
4wg0E-1wmwA:
undetectable
4wg0F-1wmwA:
undetectable
4wg0D-1wmwA:
3.13
4wg0E-1wmwA:
3.13
4wg0F-1wmwA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 8 ALA A  64
VAL A 131
GLY A  61
ALA A  51
GLY A 185
None
1.32A 4zjzB-1wmwA:
undetectable
4zjzB-1wmwA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 11 ILE A  81
GLY A  84
GLU A  86
GLY A 224
TYR A  34
None
1.16A 5ayfA-1wmwA:
undetectable
5ayfA-1wmwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ARG A  88
THR A 142
TYR A 176
GLN A 209
ASP A 212
None
0.85A 5cg5A-1wmwA:
31.6
5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.31A 5cg5A-1wmwA:
31.6
5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
None
0.92A 5cg5A-1wmwA:
31.6
5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 146
GLN A 209
None
0.91A 5cg5A-1wmwA:
31.6
5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ASP A  83
ARG A  88
THR A 142
TYR A 176
GLN A 209
None
0.52A 5cg5A-1wmwA:
31.6
5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 12 LEU A  76
ARG A  88
THR A 142
GLN A 209
ASP A 212
None
0.88A 5cg6A-1wmwA:
32.2
5cg6A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.32A 5cg6A-1wmwA:
32.2
5cg6A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 12 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 146
GLN A 209
None
0.92A 5cg6A-1wmwA:
32.2
5cg6A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 9 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
1.10A 5eroA-1wmwA:
28.6
5eroA-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 ASP A  79
ASP A  80
ASP A  83
ARG A  88
GLN A 209
None
1.09A 5eroC-1wmwA:
28.6
5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 ASP A  80
ARG A  88
GLN A 209
ASP A 212
ASP A 213
None
0.83A 5eroC-1wmwA:
28.6
5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 ASP A  80
ASP A  83
ARG A  88
GLN A 209
ASP A 213
None
0.68A 5eroC-1wmwA:
28.6
5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 10 ASP A  83
ASP A  80
ARG A  88
GLN A 209
ASP A 213
None
1.34A 5eroC-1wmwA:
28.6
5eroC-1wmwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 8 ARG A 252
ALA A 247
LEU A 256
LEU A 278
LEU A 274
None
1.37A 5jqbA-1wmwA:
undetectable
5jqbB-1wmwA:
undetectable
5jqbA-1wmwA:
24.05
5jqbB-1wmwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
3 / 3 LYS A 235
ASP A 230
ARG A 263
None
0.54A 5jwaA-1wmwA:
undetectable
5jwaH-1wmwA:
undetectable
5jwaA-1wmwA:
18.06
5jwaH-1wmwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 6 GLU A 245
ARG A 242
LEU A 238
ARG A 236
None
1.24A 5l6eA-1wmwA:
undetectable
5l6eB-1wmwA:
undetectable
5l6eA-1wmwA:
21.30
5l6eB-1wmwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 7 ASP A  79
ARG A  88
GLN A 146
GLN A 209
None
1.43A 6g31A-1wmwA:
27.8
6g31A-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 7 ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
0.87A 6g31A-1wmwA:
27.8
6g31A-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 6 ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
0.90A 6g31B-1wmwA:
28.0
6g31B-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 7 LEU A  76
ASP A  79
GLN A 146
GLN A 209
None
1.38A 6g31D-1wmwA:
27.1
6g31D-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
5 / 7 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
0.82A 6g31D-1wmwA:
27.1
6g31D-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 5 ASP A  79
ASP A  83
ARG A  88
GLN A 209
None
1.16A 6g31F-1wmwA:
28.1
6g31F-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 7 ASP A  79
ASP A  83
GLN A 146
GLN A 209
None
1.38A 6g31G-1wmwA:
27.0
6g31G-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 7 ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.11A 6g31G-1wmwA:
27.0
6g31G-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
6 / 6 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.36A 6g31J-1wmwA:
27.8
6g31J-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 6 ASP A  79
ASP A  83
GLN A 209
LYS A 235
None
1.49A 6g31L-1wmwA:
27.5
6g31L-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus)
4 / 6 ASP A  83
ARG A  88
GLN A 209
LYS A 235
None
1.33A 6g31L-1wmwA:
27.5
6g31L-1wmwA:
11.91