SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wo8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EPB_A_9CRA165_2 (EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN)	1wo8	METHYLGLYOXAL SYNTHASE (Thermus thermophilus)	4 / 7	LEU A 33 ALA A 5 VAL A 76 VAL A 68	None	0.90A	1epbA-1wo8A: undetectable	1epbA-1wo8A: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZB7_A_NCAA901_0 (PROSTAGLANDIN REDUCTASE 2)	1wo8	METHYLGLYOXAL SYNTHASE (Thermus thermophilus)	4 / 5	ILE A 120 MET A 16 LEU A 32 LEU A 27	None	1.02A	2zb7A-1wo8A: undetectable	2zb7A-1wo8A: 17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FAK_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	1wo8	METHYLGLYOXAL SYNTHASE (Thermus thermophilus)	5 / 10	ILE A 7 ILE A 42 GLY A 39 GLY A 36 MET A 16	None None None SO4 A1001 ( 4.0A) None	0.96A	4fakA-1wo8A: 3.2	4fakA-1wo8A: 24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FAK_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	1wo8	METHYLGLYOXAL SYNTHASE (Thermus thermophilus)	5 / 10	LEU A 6 ILE A 42 GLY A 39 GLY A 36 MET A 16	None None None SO4 A1001 ( 4.0A) None	0.81A	4fakA-1wo8A: 3.2	4fakA-1wo8A: 24.85

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EPB_A_9CRA165_2","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","1wo8","METHYLGLYOXAL SYNTHASE","Thermus thermophilus",4,"LEU A  33;ALA A   5;VAL A  76;VAL A  68","None","0.90A","1epbA-1wo8A:undetectable","1epbA-1wo8A:22.29"],["2ZB7_A_NCAA901_0","PROSTAGLANDIN REDUCTASE 2","1wo8","METHYLGLYOXAL SYNTHASE","Thermus thermophilus",4,"ILE A 120;MET A  16;LEU A  32;LEU A  27","None","1.02A","2zb7A-1wo8A:undetectable","2zb7A-1wo8A:17.29"],["4FAK_A_SAMA201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","1wo8","METHYLGLYOXAL SYNTHASE","Thermus thermophilus",5,"ILE A   7;ILE A  42;GLY A  39;GLY A  36;MET A  16","None;None;None;SO4 A1001 ( 4.0A);None","0.96A","4fakA-1wo8A:3.2","4fakA-1wo8A:24.85"],["4FAK_A_SAMA201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","1wo8","METHYLGLYOXAL SYNTHASE","Thermus thermophilus",5,"LEU A   6;ILE A  42;GLY A  39;GLY A  36;MET A  16","None;None;None;SO4 A1001 ( 4.0A);None","0.81A","4fakA-1wo8A:3.2","4fakA-1wo8A:24.85"]]