SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  52
ALA A 121
ILE A 120
ASP A 130
PHE A 199
 None
None
None
None
HEM  A 300 (-4.0A)
 1.43A 2b17A-1woxA:
undetectable		 2b17A-1woxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 4 LEU A  52
ILE A  68
ILE A 120
ALA A 121
 None
 0.83A 2i30A-1woxA:
undetectable		 2i30A-1woxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 7 HIS A 122
THR A 125
LEU A  52
LEU A  48
 None
HEM  A 300 (-4.7A)
None
None
 0.86A 3bgdB-1woxA:
undetectable		 3bgdB-1woxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLU A 204
VAL A 205
CYH A 100
 None
 1.06A 3fbxA-1woxA:
undetectable		 3fbxA-1woxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A  39
VAL A 205
THR A  98
 None
 0.77A 3nduD-1woxA:
undetectable		 3nduD-1woxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A  39
VAL A 205
THR A  98
 None
 0.86A 3tl9A-1woxA:
undetectable		 3tl9A-1woxA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 104
ILE A  65
ALA A 198
LEU A  56
LEU A 178
 None
 1.03A 3vw1B-1woxA:
1.8		 3vw1B-1woxA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 ARG A 167
LEU A 137
SER A 136
MET A 155
 None
 1.30A 4e1gA-1woxA:
undetectable		 4e1gA-1woxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 4 TYR A 156
ILE A 141
THR A 153
TYR A  24
 None
 1.29A 4oltA-1woxA:
0.1		 4oltA-1woxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 5 TYR A 156
ILE A 141
THR A 153
TYR A  24
 None
 1.29A 4oltB-1woxA:
0.0		 4oltB-1woxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR A 156
ILE A 141
THR A 153
TYR A  24
 None
 1.28A 4qwpA-1woxA:
0.0		 4qwpA-1woxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1wox HEME OXYGENASE 2
(Synechocystis
sp.
PCC
6803) 		4 / 4 CYH A 123
LEU A  56
LEU A  52
ALA A  55
 None
 0.91A 5hpuA-1woxA:
undetectable
5hpuB-1woxA:
undetectable		 5hpuA-1woxA:
9.30
5hpuB-1woxA:
8.16