SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		5 / 8 GLY A 235
GLY A 116
LEU A 160
ARG A 234
GLY A 187
 None
 1.41A 1jhqA-1wp5A:
undetectable		 1jhqA-1wp5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 303
LEU A  41
LYS A 310
 None
 1.44A 1yajK-1wp5A:
undetectable		 1yajK-1wp5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 126
THR A 121
VAL A 149
THR A 113
 None
 0.91A 2a1mA-1wp5A:
undetectable		 2a1mA-1wp5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		5 / 10 PHE A 159
VAL A 236
VAL A 237
VAL A 211
ILE A 209
 None
 1.46A 2qboA-1wp5A:
undetectable		 2qboA-1wp5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 249
ARG A 248
TYR A 166
GLU A 241
 None
 0.63A 2qebA-1wp5A:
undetectable		 2qebA-1wp5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 249
ARG A 248
TYR A 166
GLU A 241
 None
 0.65A 2qebB-1wp5A:
undetectable		 2qebB-1wp5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 251
ILE A 261
VAL A 210
GLN A 200
 None
 0.84A 3fi0E-1wp5A:
undetectable		 3fi0E-1wp5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 251
ILE A 261
VAL A 210
GLN A 200
 None
 0.78A 3fi0G-1wp5A:
undetectable		 3fi0G-1wp5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 251
ILE A 261
VAL A 210
GLN A 200
 None
 0.74A 3fi0I-1wp5A:
undetectable		 3fi0I-1wp5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 7 THR A 136
GLY A  60
VAL A 146
GLY A 184
 None
 0.52A 4forA-1wp5A:
undetectable		 4forA-1wp5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		4 / 7 HIS A 321
ASP A   6
GLU A  46
HIS A 322
 None
 1.03A 4hvrA-1wp5A:
undetectable		 4hvrA-1wp5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1wp5 TOPOISOMERASE IV
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  55
ILE A  82
LEU A 318
GLY A  79
LEU A  70
 None
 1.23A 6a7pA-1wp5A:
undetectable		 6a7pA-1wp5A:
18.84