SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 LEU A  30
PRO A  31
LEU A  34
 PO4  A 495 ( 4.7A)
None
None
 0.47A 1hrkA-1wp9A:
3.6		 1hrkA-1wp9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		4 / 4 SER A 453
PHE A 367
GLU A 430
GLY A 432
 None
 1.42A 1icvA-1wp9A:
0.2
1icvB-1wp9A:
0.0		 1icvA-1wp9A:
19.59
1icvB-1wp9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		5 / 11 LEU A 162
GLY A  35
ILE A  17
TYR A  18
LEU A 158
 None
PO4  A 495 (-2.8A)
None
None
None
 1.19A 1p91A-1wp9A:
4.1		 1p91A-1wp9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 TRP A 206
LYS A 344
PRO A 446
 None
 1.36A 2dqyB-1wp9A:
undetectable		 2dqyB-1wp9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 LEU A  30
PRO A  31
LEU A  34
 PO4  A 495 ( 4.7A)
None
None
 0.36A 2qd5B-1wp9A:
3.2		 2qd5B-1wp9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 THR A  49
VAL A   2
PHE A  76
VAL A  55
ALA A  44
 None
 1.14A 2x2iA-1wp9A:
undetectable		 2x2iA-1wp9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 GLU A 290
HIS A 284
HIS A 283
 None
 0.91A 3co4A-1wp9A:
undetectable		 3co4A-1wp9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 PHE A 131
ILE A  43
ALA A  44
VAL A 126
LEU A 123
 None
 1.28A 3s79A-1wp9A:
undetectable		 3s79A-1wp9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 LEU A  30
PRO A  31
LEU A  34
 PO4  A 495 ( 4.7A)
None
None
 0.38A 3w1wB-1wp9A:
5.2		 3w1wB-1wp9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 VAL A  55
GLY A  53
LYS A 103
 None
 0.78A 4k50E-1wp9A:
undetectable		 4k50E-1wp9A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 ARG A   5
ASP A   6
ARG A   4
 None
 0.64A 4wq4B-1wp9A:
undetectable		 4wq4B-1wp9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 LEU A 233
LEU A 230
ALA A 229
LEU A 280
ILE A 258
 None
 1.04A 5toaA-1wp9A:
undetectable		 5toaA-1wp9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		4 / 7 LEU A 297
PHE A 320
LEU A 332
ALA A 328
 None
 0.88A 6a7jA-1wp9A:
undetectable		 6a7jA-1wp9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 LEU A 288
GLN A 292
LYS A 303
 None
 0.94A 6exiB-1wp9A:
undetectable		 6exiB-1wp9A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 LEU A 288
GLN A 292
LYS A 303
 None
 0.98A 6exiA-1wp9A:
2.5		 6exiA-1wp9A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 ARG A  95
GLY A  88
GLU A  89
 None
 0.58A 6fgdA-1wp9A:
0.7		 6fgdA-1wp9A:
21.44