SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 ALA A  64
GLU A  67
LEU A   5
ARG A  59
 None
 0.93A 1ereE-1wpnA:
undetectable		 1ereE-1wpnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 ALA A  64
GLU A  67
LEU A   5
ARG A  59
 None
 0.93A 1ereF-1wpnA:
undetectable		 1ereF-1wpnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		5 / 11 ALA A  64
GLU A  67
LEU A   5
ARG A  59
HIS A  76
 None
 1.17A 1g50A-1wpnA:
undetectable		 1g50A-1wpnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 SER A 144
ALA A 173
PHE A  53
ILE A 172
 None
 1.16A 1gm7A-1wpnA:
undetectable
1gm7B-1wpnA:
undetectable		 1gm7A-1wpnA:
21.82
1gm7B-1wpnA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		5 / 9 GLY A  44
SER A 148
SER A 144
ASP A 149
ASP A  13
 None
None
None
MN  A 602 (-2.6A)
MN  A 601 (-2.1A)
 1.28A 1m4gB-1wpnA:
0.0		 1m4gB-1wpnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 6 GLU A  35
ASN A  28
PRO A  36
ALA A  24
 None
 1.43A 2ejfB-1wpnA:
undetectable		 2ejfB-1wpnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 6 LEU A 151
SER A 148
ASP A  13
ASP A  15
 None
None
MN  A 601 (-2.1A)
MN  A 602 (-3.1A)
 0.95A 2j2pE-1wpnA:
undetectable
2j2pF-1wpnA:
undetectable		 2j2pE-1wpnA:
21.74
2j2pF-1wpnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 6 ALA A 166
LEU A 169
ALA A 120
THR A 119
 None
 0.87A 3b6hA-1wpnA:
undetectable		 3b6hA-1wpnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 6 ALA A 166
LEU A 169
ALA A 120
THR A 119
 None
 0.86A 3b6hB-1wpnA:
undetectable		 3b6hB-1wpnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 5 HIS A  97
HIS A  98
ASP A 149
ASP A  13
 MN  A 602 (-3.4A)
None
MN  A 602 (-2.6A)
MN  A 601 (-2.1A)
 1.08A 3c0zA-1wpnA:
undetectable		 3c0zA-1wpnA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 6 HIS A  97
HIS A  98
ASP A 149
ASP A  13
 MN  A 602 (-3.4A)
None
MN  A 602 (-2.6A)
MN  A 601 (-2.1A)
 1.10A 3c0zC-1wpnA:
undetectable		 3c0zC-1wpnA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 7 TYR A  23
GLU A 114
LEU A  26
ASN A 130
 None
 1.34A 3k8mB-1wpnA:
undetectable		 3k8mB-1wpnA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 ASN A 130
GLU A  93
TYR A  23
LEU A  26
 None
 1.00A 3rqwC-1wpnA:
undetectable
3rqwD-1wpnA:
undetectable		 3rqwC-1wpnA:
20.19
3rqwD-1wpnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 ASN A 130
GLU A  93
TYR A  23
LEU A  26
 None
 1.02A 3rqwI-1wpnA:
undetectable
3rqwJ-1wpnA:
undetectable		 3rqwI-1wpnA:
20.19
3rqwJ-1wpnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 GLU A  93
TYR A  23
LEU A  26
ASN A 130
 None
 1.02A 3rqwF-1wpnA:
undetectable
3rqwJ-1wpnA:
undetectable		 3rqwF-1wpnA:
20.19
3rqwJ-1wpnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		4 / 8 THR A  46
GLU A  56
VAL A  61
LEU A  60
 None
None
None
SO4  A 703 ( 4.3A)
 0.77A 4r3aA-1wpnA:
undetectable		 4r3aA-1wpnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Bacillus
subtilis) 		5 / 9 ALA A  64
GLU A  67
LEU A   5
GLY A   8
LEU A  73
 None
 1.46A 5wgqA-1wpnA:
0.0		 5wgqA-1wpnA:
17.55