SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 212
GLY A 268
GLY A 267
PHE A 338
LEU A 217
 None
13P  A2002 (-2.8A)
SO4  A1003 ( 4.3A)
None
None
 1.00A 1ej0A-1wpqA:
3.4		 1ej0A-1wpqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 176
VAL A  79
MET A 181
ARG A 139
 None
 1.12A 1opjB-1wpqA:
undetectable		 1opjB-1wpqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A  29
LEU A 180
ILE A 166
SER A 145
 None
 0.97A 2hc4A-1wpqA:
undetectable		 2hc4A-1wpqA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 203
LEU A 261
MET A 235
GLU A 234
 None
 1.29A 2kuhA-1wpqA:
0.0		 2kuhA-1wpqA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 129
ILE A 199
ILE A 228
LEU A 321
 None
 0.80A 2xkwB-1wpqA:
undetectable		 2xkwB-1wpqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ASP A 123
ARG A 139
ILE A 136
VAL A  93
 None
 1.20A 3eigA-1wpqA:
undetectable		 3eigA-1wpqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 5 LEU A  89
LEU A 140
GLY A 141
GLY A 137
 None
 0.77A 3si7C-1wpqA:
undetectable
3si7D-1wpqA:
undetectable		 3si7C-1wpqA:
21.37
3si7D-1wpqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 219
THR A 223
GLY A 218
GLY A 220
GLY A 216
 None
 1.17A 3tegA-1wpqA:
undetectable		 3tegA-1wpqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ILE A 116
GLY A 121
GLU A 198
GLN A  96
 None
 0.95A 4g0uB-1wpqA:
undetectable		 4g0uB-1wpqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ALA A  83
ILE A 142
GLY A 115
ILE A 116
ILE A 101
 None
 1.12A 4nptA-1wpqA:
undetectable		 4nptA-1wpqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		3 / 3 SER A  11
ALA A  75
VAL A  74
 NAD  A3001 (-4.0A)
None
None
 0.66A 4x20C-1wpqA:
4.0		 4x20C-1wpqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		5 / 7 GLY A 107
LEU A 109
ILE A 142
GLY A 141
ILE A 119
 None
None
None
None
NAD  A3001 ( 4.4A)
 1.24A 5vkqA-1wpqA:
1.8
5vkqB-1wpqA:
1.8		 5vkqA-1wpqA:
12.84
5vkqB-1wpqA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		5 / 8 GLY A 107
LEU A 109
ILE A 142
GLY A 141
ILE A 119
 None
None
None
None
NAD  A3001 ( 4.4A)
 1.23A 5vkqB-1wpqA:
1.8
5vkqC-1wpqA:
1.8		 5vkqB-1wpqA:
12.84
5vkqC-1wpqA:
12.84