SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ALA A 202
GLY A 223
THR A 218
ILE A 114
 None
 0.70A 1gtnI-1wpwA:
undetectable
1gtnJ-1wpwA:
undetectable		 1gtnI-1wpwA:
12.54
1gtnJ-1wpwA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 9 MET A 279
GLY A 153
VAL A 152
GLU A 282
ILE A 149
 None
 1.31A 1pw7B-1wpwA:
3.6		 1pw7B-1wpwA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A 325
ILE A  12
VAL A 318
 None
 0.60A 2avvD-1wpwA:
undetectable		 2avvD-1wpwA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 PRO A  96
ILE A 112
ARG A 160
ASP A 111
 None
 1.40A 2rhmB-1wpwA:
2.1		 2rhmB-1wpwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 PRO A  96
ILE A 112
ARG A 160
ASP A 111
 None
 1.36A 2rhmD-1wpwA:
2.7		 2rhmD-1wpwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 227
HIS A 256
ASP A 317
 None
 0.80A 2wa2B-1wpwA:
undetectable		 2wa2B-1wpwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 283
GLU A 286
SER A 227
 None
 0.91A 2xctD-1wpwA:
undetectable		 2xctD-1wpwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 PRO A  96
LEU A 113
ARG A 159
 None
 0.82A 3aqiB-1wpwA:
undetectable		 3aqiB-1wpwA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 VAL A  17
GLY A  71
PRO A 254
PRO A 241
SER A 242
 None
 1.35A 3bjwE-1wpwA:
undetectable		 3bjwE-1wpwA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 227
LEU A 226
ARG A 116
LEU A 113
 None
None
MG  A 401 (-3.4A)
None
 0.97A 3f33A-1wpwA:
undetectable		 3f33A-1wpwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 146
ASP A 177
VAL A 199
LEU A 226
 None
 0.94A 3jq7C-1wpwA:
undetectable		 3jq7C-1wpwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A  26
ARG A  22
LYS A 312
 None
 1.36A 3okxA-1wpwA:
undetectable		 3okxA-1wpwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  43
GLY A  11
GLY A  13
ASP A  44
VAL A  81
 None
 1.12A 4b17A-1wpwA:
undetectable		 4b17A-1wpwA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  54
GLN A   8
ILE A   7
ILE A  62
ALA A  65
 None
 0.91A 4ltwA-1wpwA:
undetectable		 4ltwA-1wpwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  38
GLU A  36
ILE A   7
LEU A  69
 None
 0.89A 4mj8A-1wpwA:
undetectable		 4mj8A-1wpwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A  44
VAL A  80
ALA A 258
PHE A 260
 None
 1.16A 4nedA-1wpwA:
undetectable		 4nedA-1wpwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A  94
ARG A 160
GLY A 153
VAL A 164
 None
 0.89A 4oltA-1wpwA:
undetectable		 4oltA-1wpwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A  94
ARG A 160
GLY A 153
VAL A 164
 None
 0.93A 4oltB-1wpwA:
undetectable		 4oltB-1wpwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 ILE A  61
VAL A 277
PHE A 252
ILE A  67
 None
 0.83A 5hieC-1wpwA:
undetectable		 5hieC-1wpwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ALA A 202
ASN A 205
LEU A 206
 None
 0.46A 5i1nC-1wpwA:
undetectable		 5i1nC-1wpwA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ALA A 202
ASN A 205
LEU A 206
 None
 0.48A 5i1pD-1wpwA:
undetectable		 5i1pD-1wpwA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 8 VAL A 115
ILE A 149
ALA A 150
VAL A 164
VAL A 215
 None
 1.09A 5l94A-1wpwA:
undetectable		 5l94A-1wpwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 GLY A  43
ASP A  10
ALA A  42
ILE A   7
VAL A  73
 None
 1.22A 5yk2A-1wpwA:
undetectable		 5yk2A-1wpwA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 9 LEU A 314
PRO A 270
VAL A 307
LEU A 274
ILE A 331
 None
 1.32A 6fdyU-1wpwA:
0.0		 6fdyU-1wpwA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 ASP A  89
GLY A 223
SER A 227
ALA A 230
ASN A 244
 None
 1.30A 6hu9A-1wpwA:
1.1
6hu9E-1wpwA:
undetectable
6hu9I-1wpwA:
undetectable		 6hu9A-1wpwA:
21.67
6hu9E-1wpwA:
22.67
6hu9I-1wpwA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 ASP A  89
GLY A 223
SER A 227
ALA A 230
ASN A 244
 None
 1.21A 6hu9L-1wpwA:
0.0
6hu9P-1wpwA:
0.0
6hu9T-1wpwA:
0.0		 6hu9L-1wpwA:
21.67
6hu9P-1wpwA:
22.67
6hu9T-1wpwA:
12.12