SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 666
SER B 711
TYR B 515
VAL B 664
 None
 1.19A 2uz2A-1wpxB:
undetectable		 2uz2A-1wpxB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.36A 2zd1A-1wpxB:
undetectable		 2zd1A-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.36A 4g1qA-1wpxB:
0.0		 4g1qA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.36A 4iclA-1wpxB:
0.7		 4iclA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.36A 4id5A-1wpxB:
1.2		 4id5A-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.36A 4idkA-1wpxB:
undetectable		 4idkA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.36A 4ifvA-1wpxB:
undetectable		 4ifvA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.34A 4ifyA-1wpxB:
undetectable		 4ifyA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.35A 4ig3A-1wpxB:
0.0		 4ig3A-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.37A 4kfbA-1wpxB:
undetectable		 4kfbA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 8 ASP B 587
PHE B 634
LEU B 619
PHE B 638
 None
 0.91A 4qopC-1wpxB:
undetectable		 4qopC-1wpxB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 6 TYR B 668
GLU B 608
THR B 594
LEU B 708
 None
 1.30A 4qzuC-1wpxB:
undetectable		 4qzuC-1wpxB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.38A 5cymA-1wpxB:
undetectable		 5cymA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.41A 5cyqA-1wpxB:
undetectable		 5cyqA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 546
VAL B 538
TYR B 540
GLN B 562
 None
 1.48A 5qggA-1wpxB:
undetectable		 5qggA-1wpxB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 546
VAL B 538
TYR B 540
GLN B 562
 None
 1.46A 5qgoA-1wpxB:
0.0		 5qgoA-1wpxB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 546
VAL B 538
TYR B 540
GLN B 562
 None
 1.46A 5qgpA-1wpxB:
undetectable		 5qgpA-1wpxB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 546
VAL B 538
TYR B 540
GLN B 562
 None
 1.45A 5qgqA-1wpxB:
0.0		 5qgqA-1wpxB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 546
VAL B 538
TYR B 540
GLN B 562
 None
 1.45A 5qhbA-1wpxB:
undetectable		 5qhbA-1wpxB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 7 TRP B 688
TYR B 690
GLU B 703
SER B 680
 None
 1.32A 5umwA-1wpxB:
undetectable
5umwF-1wpxB:
undetectable		 5umwA-1wpxB:
18.18
5umwF-1wpxB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 716
PRO B 655
GLY B 657
ALA B 557
PHE B 714
 None
 1.32A 5zvgA-1wpxB:
undetectable		 5zvgA-1wpxB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 716
PRO B 655
GLY B 657
ALA B 557
PHE B 714
 None
 1.33A 5zvgB-1wpxB:
undetectable		 5zvgB-1wpxB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1wpx CARBOXYPEPTIDASE Y
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.39A 6eliA-1wpxB:
undetectable		 6eliA-1wpxB:
19.16