SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.08A 1kw0A-1wqaA:
undetectable		 1kw0A-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.17A 1mmkA-1wqaA:
undetectable		 1mmkA-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.20A 1mmtA-1wqaA:
undetectable		 1mmtA-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 337
LEU A  43
ALA A  92
VAL A  46
ALA A  96
 VAL  A 337 ( 0.6A)
LEU  A  43 ( 0.6A)
ALA  A  92 ( 0.0A)
VAL  A  46 ( 0.6A)
ALA  A  96 ( 0.0A)
 1.07A 1sa1A-1wqaA:
undetectable
1sa1B-1wqaA:
undetectable		 1sa1A-1wqaA:
23.84
1sa1B-1wqaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 337
LEU A  43
ALA A  92
VAL A  46
ALA A  96
 VAL  A 337 ( 0.6A)
LEU  A  43 ( 0.6A)
ALA  A  92 ( 0.0A)
VAL  A  46 ( 0.6A)
ALA  A  96 ( 0.0A)
 1.09A 1sa1C-1wqaA:
undetectable
1sa1D-1wqaA:
undetectable		 1sa1C-1wqaA:
23.84
1sa1D-1wqaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 310
ASP A 309
GLY A 330
ALA A 313
 LEU  A 310 ( 0.6A)
ASP  A 309 ( 0.5A)
GLY  A 330 ( 0.0A)
ALA  A 313 ( 0.0A)
 0.90A 2aohA-1wqaA:
undetectable		 2aohA-1wqaA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 342
VAL A 268
ILE A 323
GLY A 324
GLY A 325
 GLY  A 342 ( 0.0A)
VAL  A 268 ( 0.6A)
ILE  A 323 ( 0.4A)
GLY  A 324 ( 0.0A)
GLY  A 325 ( 0.0A)
 0.91A 2avvD-1wqaA:
undetectable		 2avvD-1wqaA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 283
GLY A 330
GLY A 324
VAL A 250
ILE A 259
 THR  A 283 ( 0.8A)
GLY  A 330 ( 0.0A)
GLY  A 324 ( 0.0A)
VAL  A 250 ( 0.6A)
ILE  A 259 ( 0.4A)
 1.00A 2b25A-1wqaA:
2.1		 2b25A-1wqaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 330
GLY A 324
VAL A 250
ARG A 248
ILE A 259
 GLY  A 330 ( 0.0A)
GLY  A 324 ( 0.0A)
VAL  A 250 ( 0.6A)
ARG  A 248 (-0.6A)
ILE  A 259 ( 0.4A)
 0.95A 2b25B-1wqaA:
undetectable		 2b25B-1wqaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 283
GLY A 330
GLY A 324
VAL A 250
ILE A 259
 THR  A 283 ( 0.8A)
GLY  A 330 ( 0.0A)
GLY  A 324 ( 0.0A)
VAL  A 250 ( 0.6A)
ILE  A 259 ( 0.4A)
 0.87A 2b25B-1wqaA:
undetectable		 2b25B-1wqaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 342
ALA A 343
ILE A 158
ALA A 160
ILE A 161
 GLY  A 342 ( 0.0A)
ALA  A 343 ( 0.0A)
ILE  A 158 ( 0.7A)
ALA  A 160 ( 0.0A)
ILE  A 161 ( 0.7A)
 0.90A 2b60B-1wqaA:
undetectable		 2b60B-1wqaA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 363
ASP A 237
VAL A 177
ALA A 249
VAL A 350
 LEU  A 363 ( 0.6A)
ASP  A 237 ( 0.5A)
VAL  A 177 ( 0.6A)
ALA  A 249 ( 0.0A)
VAL  A 350 ( 0.6A)
 1.20A 2g70A-1wqaA:
undetectable		 2g70A-1wqaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 363
ASP A 237
VAL A 177
ALA A 249
VAL A 350
 LEU  A 363 ( 0.6A)
ASP  A 237 ( 0.5A)
VAL  A 177 ( 0.6A)
ALA  A 249 ( 0.0A)
VAL  A 350 ( 0.6A)
 1.20A 2g70B-1wqaA:
undetectable		 2g70B-1wqaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 363
ASP A 237
VAL A 177
ALA A 249
VAL A 350
 LEU  A 363 ( 0.6A)
ASP  A 237 ( 0.5A)
VAL  A 177 ( 0.6A)
ALA  A 249 ( 0.0A)
VAL  A 350 ( 0.6A)
 1.23A 2g72A-1wqaA:
undetectable		 2g72A-1wqaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 338
GLY A 117
ARG A 340
ALA A 313
VAL A 312
 LEU  A 338 ( 0.6A)
GLY  A 117 ( 0.0A)
ARG  A 340 ( 0.6A)
ALA  A 313 ( 0.0A)
VAL  A 312 ( 0.6A)
 0.99A 2oc8A-1wqaA:
undetectable		 2oc8A-1wqaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 257
ASN A 328
THR A 264
 ARG  A 257 ( 0.6A)
ASN  A 328 ( 0.6A)
THR  A 264 ( 0.8A)
 0.85A 2q63A-1wqaA:
undetectable		 2q63A-1wqaA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 445
ASN A 444
VAL A 401
VAL A 418
THR A 375
 LEU  A 445 ( 0.6A)
ASN  A 444 ( 0.6A)
VAL  A 401 ( 0.6A)
VAL  A 418 ( 0.6A)
THR  A 375 ( 0.8A)
 1.19A 2vn0A-1wqaA:
0.0		 2vn0A-1wqaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A  20
LEU A  57
ARG A  48
 PRO  A  20 ( 1.1A)
LEU  A  57 ( 0.6A)
ARG  A  48 ( 0.6A)
 0.91A 3aqiA-1wqaA:
2.7		 3aqiA-1wqaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 117
TYR A 317
GLY A 119
ASN A 116
 GLY  A 117 ( 0.0A)
TYR  A 317 ( 1.3A)
GLY  A 119 ( 0.0A)
ASN  A 116 ( 0.6A)
 1.08A 3e9rA-1wqaA:
undetectable		 3e9rA-1wqaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 117
TYR A 317
GLY A 119
ASN A 116
 GLY  A 117 ( 0.0A)
TYR  A 317 ( 1.3A)
GLY  A 119 ( 0.0A)
ASN  A 116 ( 0.6A)
 1.09A 3e9rC-1wqaA:
undetectable		 3e9rC-1wqaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 235
ALA A 236
ASP A 237
VAL A 204
 GLY  A 235 ( 0.0A)
ALA  A 236 ( 0.0A)
ASP  A 237 ( 0.5A)
VAL  A 204 ( 0.6A)
 0.61A 3em6A-1wqaA:
undetectable		 3em6A-1wqaA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 VAL A  83
ILE A  18
ALA A  96
LEU A 113
 VAL  A  83 ( 0.6A)
ILE  A  18 ( 0.7A)
ALA  A  96 ( 0.0A)
LEU  A 113 ( 0.6A)
 0.84A 3kk6B-1wqaA:
undetectable		 3kk6B-1wqaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 245
SER A 101
ARG A 248
 ASP  A 245 (-0.6A)
SER  A 101 (-0.0A)
ARG  A 248 (-0.6A)
 0.88A 3loqA-1wqaA:
2.5		 3loqA-1wqaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  98
ALA A  60
LEU A  61
LEU A 112
 ILE  A  98 ( 0.7A)
ALA  A  60 ( 0.0A)
LEU  A  61 ( 0.6A)
LEU  A 112 ( 0.6A)
 0.76A 3ozwA-1wqaA:
undetectable		 3ozwA-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 269
VAL A 272
LEU A 280
THR A 322
 ALA  A 269 ( 0.0A)
VAL  A 272 ( 0.6A)
LEU  A 280 ( 0.6A)
THR  A 322 ( 0.8A)
 0.80A 3roxA-1wqaA:
4.4		 3roxA-1wqaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 SER A 356
ASP A 270
ASP A 293
 SER  A 356 ( 0.0A)
ASP  A 270 ( 0.6A)
ASP  A 293 ( 0.6A)
 0.84A 3uj7A-1wqaA:
undetectable		 3uj7A-1wqaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A 210
THR A  50
ASN A 183
 GLY  A 210 ( 0.0A)
THR  A  50 ( 0.8A)
ASN  A 183 ( 0.6A)
 0.62A 3v4tD-1wqaA:
undetectable		 3v4tD-1wqaA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 GLN A 207
THR A  50
ASN A 183
 GLN  A 207 ( 0.6A)
THR  A  50 ( 0.8A)
ASN  A 183 ( 0.6A)
 0.90A 3v4tE-1wqaA:
undetectable		 3v4tE-1wqaA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 234
VAL A 231
ASP A 237
GLU A 254
 LEU  A 234 ( 0.6A)
VAL  A 231 ( 0.6A)
ASP  A 237 ( 0.5A)
GLU  A 254 ( 0.6A)
 0.83A 4g24A-1wqaA:
undetectable		 4g24A-1wqaA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 VAL A  72
GLY A  27
SER A  67
GLY A  69
ASP A  74
 VAL  A  72 ( 0.6A)
GLY  A  27 ( 0.0A)
SER  A  67 ( 0.0A)
GLY  A  69 ( 0.0A)
ASP  A  74 ( 0.6A)
 1.04A 4mm9A-1wqaA:
undetectable		 4mm9A-1wqaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 342
ALA A 249
VAL A 240
LEU A 190
ILE A 161
 GLY  A 342 ( 0.0A)
ALA  A 249 ( 0.0A)
VAL  A 240 ( 0.6A)
LEU  A 190 ( 0.6A)
ILE  A 161 ( 0.7A)
 1.11A 4pd5A-1wqaA:
undetectable		 4pd5A-1wqaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 342
ALA A 249
VAL A 240
LEU A 190
ILE A 161
 GLY  A 342 ( 0.0A)
ALA  A 249 ( 0.0A)
VAL  A 240 ( 0.6A)
LEU  A 190 ( 0.6A)
ILE  A 161 ( 0.7A)
 1.07A 4pd9A-1wqaA:
undetectable		 4pd9A-1wqaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 5 THR A 284
THR A 305
THR A   7
ASN A 328
 THR  A 284 ( 0.8A)
THR  A 305 ( 0.8A)
THR  A   7 ( 0.8A)
ASN  A 328 ( 0.6A)
 1.35A 4pgfB-1wqaA:
2.4		 4pgfB-1wqaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  92
VAL A 128
LEU A  34
LEU A  61
LEU A  65
 ALA  A  92 ( 0.0A)
VAL  A 128 ( 0.6A)
LEU  A  34 ( 0.6A)
LEU  A  61 ( 0.6A)
LEU  A  65 ( 0.6A)
 1.18A 4qzuC-1wqaA:
undetectable		 4qzuC-1wqaA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 SER A 182
ALA A 241
VAL A 240
 SER  A 182 ( 0.0A)
ALA  A 241 ( 0.0A)
VAL  A 240 ( 0.6A)
 0.51A 4x20C-1wqaA:
undetectable		 4x20C-1wqaA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  11
ARG A  51
ASP A 245
VAL A  10
 ARG  A  11 ( 0.6A)
ARG  A  51 ( 0.6A)
ASP  A 245 (-0.6A)
VAL  A  10 ( 0.6A)
 0.92A 4xqeA-1wqaA:
undetectable		 4xqeA-1wqaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  11
ARG A  51
ASP A 245
VAL A  10
 ARG  A  11 ( 0.6A)
ARG  A  51 ( 0.6A)
ASP  A 245 (-0.6A)
VAL  A  10 ( 0.6A)
 0.96A 4xqeB-1wqaA:
undetectable		 4xqeB-1wqaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A  11
ARG A  51
ASP A 245
VAL A  10
 ARG  A  11 ( 0.6A)
ARG  A  51 ( 0.6A)
ASP  A 245 (-0.6A)
VAL  A  10 ( 0.6A)
 0.97A 4xqgA-1wqaA:
undetectable		 4xqgA-1wqaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A  11
ARG A  51
ASP A 245
VAL A  10
 ARG  A  11 ( 0.6A)
ARG  A  51 ( 0.6A)
ASP  A 245 (-0.6A)
VAL  A  10 ( 0.6A)
 0.96A 4xqgB-1wqaA:
undetectable		 4xqgB-1wqaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 154
LEU A 188
GLY A  76
ILE A  77
GLY A  95
 ILE  A 154 ( 0.7A)
LEU  A 188 ( 0.6A)
GLY  A  76 ( 0.0A)
ILE  A  77 ( 0.7A)
GLY  A  95 ( 0.0A)
 1.02A 5d4uD-1wqaA:
undetectable		 5d4uD-1wqaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 363
ARG A 257
ILE A 364
ILE A 259
 LEU  A 363 ( 0.6A)
ARG  A 257 ( 0.6A)
ILE  A 364 ( 0.7A)
ILE  A 259 ( 0.4A)
 1.38A 5dzk2-1wqaA:
undetectable
5dzkM-1wqaA:
undetectable
5dzkN-1wqaA:
undetectable		 5dzk2-1wqaA:
5.88
5dzkM-1wqaA:
18.86
5dzkN-1wqaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 364
ILE A 259
ARG A 257
LEU A 363
 ILE  A 364 ( 0.7A)
ILE  A 259 ( 0.4A)
ARG  A 257 ( 0.6A)
LEU  A 363 ( 0.6A)
 1.30A 5dzkh-1wqaA:
undetectable
5dzkn-1wqaA:
undetectable
5dzkv-1wqaA:
undetectable		 5dzkh-1wqaA:
18.86
5dzkn-1wqaA:
18.86
5dzkv-1wqaA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 243
VAL A 250
LEU A 224
 ASP  A 243 (-0.6A)
VAL  A 250 ( 0.6A)
LEU  A 224 ( 0.6A)
 0.66A 5e5jB-1wqaA:
undetectable		 5e5jB-1wqaA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 155
ASP A 152
ILE A 161
 LYS  A 155 ( 0.0A)
ASP  A 152 ( 0.6A)
ILE  A 161 ( 0.7A)
 0.87A 5kc4E-1wqaA:
0.0		 5kc4E-1wqaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 268
GLY A 342
PHE A 333
ALA A 343
TYR A 157
 VAL  A 268 ( 0.6A)
GLY  A 342 ( 0.0A)
PHE  A 333 ( 1.3A)
ALA  A 343 ( 0.0A)
TYR  A 157 ( 1.3A)
 1.11A 5n5dA-1wqaA:
undetectable		 5n5dA-1wqaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 194
PHE A 360
GLY A 235
PHE A 353
ALA A 354
 LEU  A 194 ( 0.6A)
PHE  A 360 ( 1.3A)
GLY  A 235 ( 0.0A)
PHE  A 353 ( 1.3A)
ALA  A 354 ( 0.0A)
 0.95A 5veuH-1wqaA:
undetectable		 5veuH-1wqaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 401
GLY A 406
LEU A 445
LEU A 449
ALA A 394
 VAL  A 401 ( 0.6A)
GLY  A 406 ( 0.0A)
LEU  A 445 ( 0.6A)
LEU  A 449 ( 0.6A)
ALA  A 394 ( 0.0A)
 1.07A 5vm8B-1wqaA:
undetectable		 5vm8B-1wqaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 273
VAL A 268
VAL A 331
GLY A 325
THR A 305
 LEU  A 273 ( 0.6A)
VAL  A 268 ( 0.6A)
VAL  A 331 ( 0.6A)
GLY  A 325 ( 0.0A)
THR  A 305 ( 0.8A)
 1.13A 5x24A-1wqaA:
undetectable		 5x24A-1wqaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  34
LEU A  33
LEU A 113
GLY A 119
 LEU  A  34 ( 0.6A)
LEU  A  33 ( 0.6A)
LEU  A 113 ( 0.6A)
GLY  A 119 ( 0.0A)
 0.77A 6ce2A-1wqaA:
undetectable		 6ce2A-1wqaA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 198
ASP A 166
ILE A 158
VAL A 346
VAL A 350
 GLY  A 198 ( 0.0A)
ASP  A 166 ( 0.6A)
ILE  A 158 ( 0.7A)
VAL  A 346 ( 0.6A)
VAL  A 350 ( 0.6A)
 0.88A 6dh0B-1wqaA:
undetectable		 6dh0B-1wqaA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 158
HIS A 336
ALA A 347
GLY A 342
ALA A  82
 ILE  A 158 ( 0.7A)
HIS  A 336 ( 1.0A)
ALA  A 347 ( 0.0A)
GLY  A 342 ( 0.0A)
ALA  A  82 ( 0.0A)
 1.17A 6ieyA-1wqaA:
2.4
6ieyB-1wqaA:
2.2		 6ieyA-1wqaA:
23.79
6ieyB-1wqaA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A  36
LEU A 131
PHE A 132
 ARG  A  36 ( 0.6A)
LEU  A 131 ( 0.6A)
PHE  A 132 ( 1.3A)
 0.80A 6nknP-1wqaA:
0.0		 6nknP-1wqaA:
21.34