SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_B_PNNB301_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	1wr1	UBIQUITIN-LIKE PROTEIN DSK2 (Saccharomyces cerevisiae)	5 / 12	GLY B 358 GLY B 359 SER B 360 GLY B 363 ASP B 366	None	0.87A	3huoB-1wr1B: undetectable	3huoB-1wr1B: 15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FQS_A_LYAA302_1 (THYMIDYLATE SYNTHASE)	1wr1	UBIQUITIN-LIKE PROTEIN DSK2 (Saccharomyces cerevisiae)	5 / 12	HIS B 334 LEU B 354 GLY B 359 VAL B 351 ALA B 352	None	1.21A	4fqsA-1wr1B: undetectable	4fqsA-1wr1B: 13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FQS_B_LYAB302_1 (THYMIDYLATE SYNTHASE)	1wr1	UBIQUITIN-LIKE PROTEIN DSK2 (Saccharomyces cerevisiae)	5 / 12	HIS B 334 LEU B 354 GLY B 359 VAL B 351 ALA B 352	None	1.21A	4fqsB-1wr1B: undetectable	4fqsB-1wr1B: 13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_D_BEZD201_0 (NS3 PROTEASE)	1wr1	UBIQUITIN-LIKE PROTEIN DSK2 (Saccharomyces cerevisiae)	4 / 5	ALA B 353 SER B 357 GLY B 358 TYR B 332	None	1.19A	5yodD-1wr1B: undetectable	5yodD-1wr1B: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_D_BEZD201_0 (NS3 PROTEASE)	1wr1	UBIQUITIN-LIKE PROTEIN DSK2 (Saccharomyces cerevisiae)	4 / 5	ALA B 364 SER B 357 GLY B 358 TYR B 332	None	1.19A	5yodD-1wr1B: undetectable	5yodD-1wr1B: 19.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3HUO_B_PNNB301_0","CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE","1wr1","UBIQUITIN-LIKE PROTEIN DSK2","Saccharomyces cerevisiae",5,"GLY B 358;GLY B 359;SER B 360;GLY B 363;ASP B 366","None","0.87A","3huoB-1wr1B:undetectable","3huoB-1wr1B:15.71"],["4FQS_A_LYAA302_1","THYMIDYLATE SYNTHASE","1wr1","UBIQUITIN-LIKE PROTEIN DSK2","Saccharomyces cerevisiae",5,"HIS B 334;LEU B 354;GLY B 359;VAL B 351;ALA B 352","None","1.21A","4fqsA-1wr1B:undetectable","4fqsA-1wr1B:13.31"],["4FQS_B_LYAB302_1","THYMIDYLATE SYNTHASE","1wr1","UBIQUITIN-LIKE PROTEIN DSK2","Saccharomyces cerevisiae",5,"HIS B 334;LEU B 354;GLY B 359;VAL B 351;ALA B 352","None","1.21A","4fqsB-1wr1B:undetectable","4fqsB-1wr1B:13.31"],["5YOD_D_BEZD201_0","NS3 PROTEASE","1wr1","UBIQUITIN-LIKE PROTEIN DSK2","Saccharomyces cerevisiae",4,"ALA B 353;SER B 357;GLY B 358;TYR B 332","None","1.19A","5yodD-1wr1B:undetectable","5yodD-1wr1B:19.11"],["5YOD_D_BEZD201_0","NS3 PROTEASE","1wr1","UBIQUITIN-LIKE PROTEIN DSK2","Saccharomyces cerevisiae",4,"ALA B 364;SER B 357;GLY B 358;TYR B 332","None","1.19A","5yodD-1wr1B:undetectable","5yodD-1wr1B:19.11"]]