SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1wr2 HYPOTHETICAL PROTEIN
PH1789
(Pyrococcus
horikoshii) 		4 / 8 ARG A 231
VAL A  36
LEU A  34
VAL A 197
 None
 0.94A 2bdmA-1wr2A:
undetectable		 2bdmA-1wr2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1wr2 HYPOTHETICAL PROTEIN
PH1789
(Pyrococcus
horikoshii) 		3 / 3 ASN A  97
LEU A  63
HIS A  95
 None
 0.72A 2q6fB-1wr2A:
0.0		 2q6fB-1wr2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1wr2 HYPOTHETICAL PROTEIN
PH1789
(Pyrococcus
horikoshii) 		5 / 12 TYR A 219
GLY A 119
VAL A 228
ALA A 189
PHE A 138
 None
 1.31A 3qowA-1wr2A:
undetectable		 3qowA-1wr2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1wr2 HYPOTHETICAL PROTEIN
PH1789
(Pyrococcus
horikoshii) 		4 / 8 ASN A  97
ALA A  98
PRO A 103
LEU A  63
 None
 0.91A 4jjkA-1wr2A:
undetectable		 4jjkA-1wr2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1wr2 HYPOTHETICAL PROTEIN
PH1789
(Pyrococcus
horikoshii) 		4 / 5 TYR A 219
LEU A 176
GLU A 121
VAL A 145
 None
 1.26A 4nkvA-1wr2A:
undetectable		 4nkvA-1wr2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1wr2 HYPOTHETICAL PROTEIN
PH1789
(Pyrococcus
horikoshii) 		4 / 8 ILE A 124
VAL A 122
ILE A 190
TYR A 219
 None
 1.07A 6cduG-1wr2A:
undetectable
6cduH-1wr2A:
undetectable		 6cduG-1wr2A:
22.74
6cduH-1wr2A:
22.74