SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		4 / 8 HIS A 216
VAL A 221
LEU A 262
THR A 261
 None
 0.87A 2gehA-1wr6A:
undetectable		 2gehA-1wr6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		5 / 10 LEU A 280
GLY A 277
LEU A 276
SER A 275
ALA A 266
 None
 0.93A 2v3kA-1wr6A:
undetectable		 2v3kA-1wr6A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 PHE A 263
SER A 287
SER A 283
 None
 0.88A 3ufgB-1wr6A:
undetectable		 3ufgB-1wr6A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		4 / 6 LEU A 286
LEU A 228
VAL A 225
PHE A 252
 None
 1.19A 4uswA-1wr6A:
undetectable		 4uswA-1wr6A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		5 / 10 LEU A 276
LEU A 262
ALA A 266
SER A 287
LEU A 286
 None
 1.01A 4zbrA-1wr6A:
2.4		 4zbrA-1wr6A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 ALA A 282
ASN A 285
LEU A 286
 None
 0.47A 5i1oA-1wr6A:
undetectable		 5i1oA-1wr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1wr6 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 ALA A 282
ASN A 285
LEU A 286
 None
 0.49A 5i1pD-1wr6A:
undetectable		 5i1pD-1wr6A:
14.29