SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.01A 1rxcC-1wr8A:
3.4		 1rxcC-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.05A 1rxcD-1wr8A:
undetectable		 1rxcD-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.06A 1rxcL-1wr8A:
3.0		 1rxcL-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 SER A   7
ILE A 158
ALA A 184
ALA A 205
 None
 0.96A 1w0gA-1wr8A:
undetectable		 1w0gA-1wr8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 THR A  15
TYR A 104
ASN A  45
PHE A 143
 None
None
ACT  A 600 ( 4.1A)
ACT  A 600 (-4.4A)
 1.11A 2hzqA-1wr8A:
undetectable		 2hzqA-1wr8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLU A 179
ALA A 193
PRO A 198
ALA A 197
 None
 1.17A 2zgwB-1wr8A:
undetectable		 2zgwB-1wr8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A 149
LEU A 134
GLU A  85
ASP A  84
 None
 1.30A 3dzgA-1wr8A:
undetectable		 3dzgA-1wr8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  13
THR A  15
LEU A  41
ILE A  57
HIS A 174
 None
 1.41A 3gwxB-1wr8A:
undetectable		 3gwxB-1wr8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A  33
GLY A  36
VAL A 175
SER A  60
ILE A  39
 None
 1.28A 3k13A-1wr8A:
undetectable		 3k13A-1wr8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A  33
GLY A  36
VAL A 175
SER A  60
ILE A  39
 None
 1.26A 3k13B-1wr8A:
undetectable		 3k13B-1wr8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A  33
GLY A  36
VAL A 175
SER A  60
ILE A  39
 None
 1.27A 3k13C-1wr8A:
undetectable		 3k13C-1wr8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.07A 3kvvA-1wr8A:
3.5		 3kvvA-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.05A 3kvvB-1wr8A:
undetectable		 3kvvB-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.05A 3kvvC-1wr8A:
3.7		 3kvvC-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.02A 3kvvD-1wr8A:
3.5		 3kvvD-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.08A 3kvvE-1wr8A:
undetectable		 3kvvE-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.09A 3kvvF-1wr8A:
undetectable		 3kvvF-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 173
ILE A 167
GLY A  36
ALA A  32
ILE A 224
 None
 1.05A 3lbdA-1wr8A:
undetectable		 3lbdA-1wr8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 148
VAL A 139
HIS A 146
 None
 0.94A 3tj7A-1wr8A:
undetectable		 3tj7A-1wr8A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.03A 4e1vB-1wr8A:
undetectable		 4e1vB-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 176
GLN A 196
ILE A   8
VAL A 175
 None
 1.07A 4e1vF-1wr8A:
3.5		 4e1vF-1wr8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 158
ILE A  39
ALA A 161
ILE A 167
VAL A 172
 None
 1.15A 4h1nA-1wr8A:
undetectable		 4h1nA-1wr8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  89
LEU A 113
VAL A 147
ILE A 145
 None
 0.86A 4oj4A-1wr8A:
undetectable		 4oj4A-1wr8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 150
ASN A 133
ARG A  96
GLU A  86
LEU A  89
 None
 1.32A 4x61A-1wr8A:
2.9		 4x61A-1wr8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 182
ASP A 181
GLY A 176
ALA A 193
ILE A 200
 None
 1.00A 4xdrA-1wr8A:
undetectable		 4xdrA-1wr8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A 207
PHE A 185
GLY A 176
THR A  13
 None
 1.02A 5esmA-1wr8A:
undetectable		 5esmA-1wr8A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 11 THR A  13
GLY A 216
ALA A 220
THR A 209
LEU A 231
 None
 0.95A 5lf7H-1wr8A:
2.2
5lf7I-1wr8A:
undetectable		 5lf7H-1wr8A:
22.18
5lf7I-1wr8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 11 THR A  13
GLY A 216
ALA A 220
THR A 209
LEU A 231
 None
 0.95A 5lf7V-1wr8A:
undetectable
5lf7W-1wr8A:
undetectable		 5lf7V-1wr8A:
22.18
5lf7W-1wr8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 185
ASP A   9
ILE A  37
THR A  13
PHE A 228
 None
 1.16A 5vcgA-1wr8A:
undetectable		 5vcgA-1wr8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 4 VAL A 187
GLY A 155
ASP A 183
ASP A 181
 None
 1.23A 6cjkC-1wr8A:
undetectable		 6cjkC-1wr8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 217
GLY A 214
ILE A  29
VAL A 175
ILE A   6
 None
 1.03A 6ectA-1wr8A:
2.1		 6ectA-1wr8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 217
GLY A 214
ILE A  29
VAL A 175
ILE A   6
 None
 1.02A 6ecxA-1wr8A:
undetectable		 6ecxA-1wr8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 201
ILE A 158
ALA A 184
HIS A 174
ASP A   9
 None
 1.24A 6n91A-1wr8A:
undetectable		 6n91A-1wr8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 201
ILE A 158
ALA A 184
HIS A 174
ASP A   9
 None
 1.26A 6n91B-1wr8A:
undetectable		 6n91B-1wr8A:
20.73