SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.82A 1fm9A-1wraA:
undetectable		 1fm9A-1wraA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 11 LEU A 273
PHE A 105
ALA A  55
VAL A 275
MET A 184
 None
 1.07A 1hbpA-1wraA:
undetectable		 1hbpA-1wraA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.86A 1k74A-1wraA:
undetectable		 1k74A-1wraA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 THR A 111
ASP A 207
ASN A 210
LEU A 158
 None
 1.05A 1lhvA-1wraA:
undetectable		 1lhvA-1wraA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 SER A  50
GLN A 180
PHE A 181
ASN A  31
 None
 1.07A 1p6kA-1wraA:
undetectable		 1p6kA-1wraA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 LEU A 273
PHE A 105
ALA A  55
VAL A 275
MET A 184
 None
 1.07A 1rbpA-1wraA:
undetectable		 1rbpA-1wraA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 SER A  50
GLN A 180
PHE A 181
ASN A  31
 None
 1.04A 1rs6A-1wraA:
undetectable		 1rs6A-1wraA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 SER A  50
GLN A 180
PHE A 181
ASN A  31
 None
 1.01A 1rs6B-1wraA:
undetectable		 1rs6B-1wraA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.94A 1xiuB-1wraA:
undetectable		 1xiuB-1wraA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.89A 1xlsB-1wraA:
undetectable		 1xlsB-1wraA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.90A 1xlsC-1wraA:
undetectable		 1xlsC-1wraA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.89A 1xlsD-1wraA:
undetectable		 1xlsD-1wraA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 SER A  50
GLN A 180
PHE A 181
ASN A  31
 None
 1.07A 1zzqA-1wraA:
undetectable		 1zzqA-1wraA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 SER A  50
GLN A 180
PHE A 181
ASN A  31
 None
 1.06A 1zzuA-1wraA:
undetectable		 1zzuA-1wraA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 5 LEU A 295
ILE A 266
LEU A 269
SER A 270
 None
 1.00A 2byoA-1wraA:
undetectable		 2byoA-1wraA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		3 / 3 ALA A 235
VAL A 232
TRP A 205
 None
 0.99A 2izqA-1wraA:
undetectable
2izqB-1wraA:
undetectable		 2izqA-1wraA:
3.85
2izqB-1wraA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 THR A 111
ASN A 193
THR A  59
VAL A 157
THR A 162
 None
 0.95A 2nniA-1wraA:
undetectable		 2nniA-1wraA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 7 ASP A  67
PHE A  65
TYR A  73
PRO A  66
 None
 1.50A 2q6kA-1wraA:
undetectable		 2q6kA-1wraA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 256
PHE A 251
ASP A 288
TYR A 291
 None
 1.15A 2todA-1wraA:
0.3
2todB-1wraA:
0.3		 2todA-1wraA:
22.07
2todB-1wraA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 5 ASP A 256
PHE A 251
ASP A 288
TYR A 291
 None
 1.17A 2todC-1wraA:
0.3
2todD-1wraA:
0.1		 2todC-1wraA:
22.07
2todD-1wraA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 5 ASP A 288
TYR A 291
ASP A 256
PHE A 251
 None
 1.15A 2todC-1wraA:
0.3
2todD-1wraA:
0.1		 2todC-1wraA:
22.07
2todD-1wraA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		3 / 3 SER A 214
HIS A  34
ASP A 316
 None
 0.73A 2wa2B-1wraA:
undetectable		 2wa2B-1wraA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  46
LEU A 225
ILE A  47
PHE A 179
PHE A 181
 None
 1.17A 2ygpA-1wraA:
undetectable		 2ygpA-1wraA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ALA A 305
SER A  43
THR A 277
VAL A 275
 None
 0.94A 3d2tB-1wraA:
undetectable		 3d2tB-1wraA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 ASP A  62
ASP A  64
ASP A  58
ASP A 207
 CA  A 404 ( 3.1A)
None
None
None
 1.04A 3havA-1wraA:
undetectable		 3havA-1wraA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 PHE A  35
ASP A  44
VAL A  57
LEU A  48
 None
 1.13A 3jq7C-1wraA:
undetectable		 3jq7C-1wraA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 HIS A  34
VAL A 275
SER A 326
LEU A 273
 None
 0.92A 3kk6A-1wraA:
undetectable		 3kk6A-1wraA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 HIS A 110
GLY A 227
GLY A  41
ASN A 304
 FE  A 401 (-3.5A)
None
None
None
 0.98A 3v3nB-1wraA:
undetectable		 3v3nB-1wraA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 HIS A 110
GLY A 227
GLY A  41
ASN A 304
 FE  A 401 (-3.5A)
None
None
None
 0.97A 3v3nC-1wraA:
undetectable		 3v3nC-1wraA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 9 HIS A 112
ASP A 114
HIS A 110
ASN A 208
HIS A 254
 FE  A 401 ( 3.3A)
FE  A 402 ( 2.6A)
FE  A 401 (-3.5A)
PC  A 501 ( 2.6A)
FE  A 402 ( 3.4A)
 1.42A 4c1dA-1wraA:
10.0		 4c1dA-1wraA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 10 HIS A 112
ASP A 114
HIS A 110
ASN A 208
HIS A 254
 FE  A 401 ( 3.3A)
FE  A 402 ( 2.6A)
FE  A 401 (-3.5A)
PC  A 501 ( 2.6A)
FE  A 402 ( 3.4A)
 1.43A 4c1dB-1wraA:
10.1		 4c1dB-1wraA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 10 GLY A 117
ASP A 114
GLY A  60
HIS A 110
HIS A 254
 CA  A 403 (-4.4A)
FE  A 402 ( 2.6A)
None
FE  A 401 (-3.5A)
FE  A 402 ( 3.4A)
 1.12A 4c5nB-1wraA:
undetectable		 4c5nB-1wraA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 10 GLY A 117
ASP A 114
GLY A  60
VAL A 108
HIS A 254
 CA  A 403 (-4.4A)
FE  A 402 ( 2.6A)
None
None
FE  A 402 ( 3.4A)
 1.28A 4c5nD-1wraA:
undetectable		 4c5nD-1wraA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ASN A 268
GLY A 234
ALA A 235
GLY A 240
LEU A 242
 None
 1.02A 4e1gA-1wraA:
undetectable		 4e1gA-1wraA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 ASP A 120
ASP A 149
ASP A  62
GLU A  61
 CA  A 403 (-2.6A)
None
CA  A 404 ( 3.1A)
CA  A 404 (-3.3A)
 1.13A 4gkhC-1wraA:
undetectable
4gkhK-1wraA:
undetectable		 4gkhC-1wraA:
21.84
4gkhK-1wraA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 8 ASP A 120
ASP A 149
ASP A  62
GLU A  61
 CA  A 403 (-2.6A)
None
CA  A 404 ( 3.1A)
CA  A 404 (-3.3A)
 1.12A 4gkiE-1wraA:
undetectable
4gkiG-1wraA:
undetectable		 4gkiE-1wraA:
21.84
4gkiG-1wraA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 PHE A 265
ILE A 266
TYR A 291
PHE A 251
 None
 1.11A 4o7gB-1wraA:
undetectable		 4o7gB-1wraA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		3 / 3 THR A 262
ASN A 231
SER A 260
 None
 0.73A 4tvtA-1wraA:
undetectable		 4tvtA-1wraA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.42A 4w5qA-1wraA:
undetectable		 4w5qA-1wraA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.42A 4w5rA-1wraA:
undetectable		 4w5rA-1wraA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.41A 4w5tA-1wraA:
undetectable		 4w5tA-1wraA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.43A 4z4cA-1wraA:
undetectable		 4z4cA-1wraA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.44A 4z4fA-1wraA:
undetectable		 4z4fA-1wraA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
LYS A 134
THR A 111
TYR A 136
 None
 1.47A 4z4iA-1wraA:
undetectable		 4z4iA-1wraA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 11 HIS A 110
HIS A 112
ASP A 114
HIS A 115
HIS A 254
 FE  A 401 (-3.5A)
FE  A 401 ( 3.3A)
FE  A 402 ( 2.6A)
FE  A 402 (-3.3A)
FE  A 402 ( 3.4A)
 0.48A 5ayaA-1wraA:
11.1		 5ayaA-1wraA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		4 / 5 THR A 277
GLY A  42
HIS A 112
ASP A  44
 None
None
FE  A 401 ( 3.3A)
None
 1.22A 5c0oH-1wraA:
undetectable		 5c0oH-1wraA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 10 HIS A 110
HIS A 112
HIS A 115
ASP A 228
HIS A 253
 FE  A 401 (-3.5A)
FE  A 401 ( 3.3A)
FE  A 402 (-3.3A)
FE  A 402 (-2.5A)
PC  A 501 (-3.6A)
 0.68A 5nzwA-1wraA:
7.6		 5nzwA-1wraA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.94A 5z12B-1wraA:
undetectable		 5z12B-1wraA:
12.33