SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 4 THR A 235
LEU A 239
LEU A 246
GLN A 249
 SO4  A1001 (-3.8A)
None
None
None
 1.15A 1fbmA-1wrbA:
undetectable		 1fbmA-1wrbA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 7 PHE A 238
ASP A 342
ILE A 266
VAL A 316
 None
 0.77A 1p2yA-1wrbA:
undetectable		 1p2yA-1wrbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 5 ALA A 226
TYR A 395
ILE A 224
ASP A 176
 None
 1.24A 1upfA-1wrbA:
2.6		 1upfA-1wrbA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 7 ILE A 183
LEU A 374
ILE A 242
ILE A 266
 None
 0.83A 1uwjA-1wrbA:
undetectable		 1uwjA-1wrbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wrb DJVLGB
(Dugesia
japonica) 		5 / 12 CYH A 227
SER A 377
ALA A 344
ILE A 384
ILE A 224
 None
 1.00A 3adxB-1wrbA:
undetectable		 3adxB-1wrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wrb DJVLGB
(Dugesia
japonica) 		5 / 12 CYH A 227
SER A 377
ALA A 344
ILE A 384
LEU A 392
 None
 1.01A 3adxB-1wrbA:
undetectable		 3adxB-1wrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1wrb DJVLGB
(Dugesia
japonica) 		5 / 12 LEU A 239
ILE A 218
ILE A 277
ALA A 268
PHE A 376
 None
 1.20A 3vw1D-1wrbA:
undetectable		 3vw1D-1wrbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 7 LEU A 265
MET A 347
LEU A 341
ILE A 218
 None
 1.03A 4okwA-1wrbA:
undetectable		 4okwA-1wrbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1wrb DJVLGB
(Dugesia
japonica) 		3 / 3 GLY A 320
PRO A 319
ALA A 268
 None
 0.51A 4qn9B-1wrbA:
undetectable		 4qn9B-1wrbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wrb DJVLGB
(Dugesia
japonica) 		5 / 9 CYH A 227
SER A 377
ALA A 344
LEU A 392
ILE A 224
 None
 1.05A 4xtaA-1wrbA:
undetectable		 4xtaA-1wrbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wrb DJVLGB
(Dugesia
japonica) 		5 / 11 CYH A 227
SER A 377
ALA A 344
ILE A 384
ILE A 224
 None
 1.02A 4xumB-1wrbA:
undetectable		 4xumB-1wrbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wrb DJVLGB
(Dugesia
japonica) 		5 / 11 CYH A 227
SER A 377
ALA A 344
ILE A 384
LEU A 392
 None
 1.00A 4xumB-1wrbA:
undetectable		 4xumB-1wrbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 8 ILE A 266
VAL A 316
GLN A 276
GLU A 280
 None
 0.91A 5dqyA-1wrbA:
undetectable		 5dqyA-1wrbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1wrb DJVLGB
(Dugesia
japonica) 		3 / 3 CYH A 264
LYS A 263
HIS A 313
 None
 1.08A 5js5A-1wrbA:
undetectable		 5js5A-1wrbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1wrb DJVLGB
(Dugesia
japonica) 		4 / 6 SER A 232
GLU A 343
ARG A 346
ASP A 349
 SO4  A1001 (-3.6A)
None
None
None
 1.14A 5zw4A-1wrbA:
4.1		 5zw4A-1wrbA:
23.81