SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wrm DUAL SPECIFICITY
PHOSPHATASE 22
(Homo
sapiens) 		5 / 12 GLY A  91
GLY A  15
GLN A  61
ASP A  57
SER A  93
 MES  A 164 (-4.1A)
None
None
MES  A 164 (-3.6A)
MES  A 164 (-4.2A)
 1.14A 1wg8A-1wrmA:
undetectable		 1wg8A-1wrmA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1wrm DUAL SPECIFICITY
PHOSPHATASE 22
(Homo
sapiens) 		5 / 9 THR A 107
LEU A 150
TYR A 154
THR A 105
LEU A  79
 None
 0.96A 2npnA-1wrmA:
2.9		 2npnA-1wrmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1wrm DUAL SPECIFICITY
PHOSPHATASE 22
(Homo
sapiens) 		4 / 5 VAL A  99
VAL A  96
GLN A 132
PHE A 109
 None
 1.36A 3bjwH-1wrmA:
undetectable		 3bjwH-1wrmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wrm DUAL SPECIFICITY
PHOSPHATASE 22
(Homo
sapiens) 		4 / 8 ILE A  14
SER A  70
LEU A  63
ILE A 100
 None
 0.98A 4xtaB-1wrmA:
undetectable		 4xtaB-1wrmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1wrm DUAL SPECIFICITY
PHOSPHATASE 22
(Homo
sapiens) 		3 / 3 HIS A  38
SER A  36
ARG A  21
 None
 0.92A 5u63A-1wrmA:
undetectable		 5u63A-1wrmA:
21.07